Peripheral leukocyte populations and oxidative stress biomarkers in aged dogs showing impaired cognitive abilities

Mongillo, Paolo; Bertotto, Daniela; Pitteri, Elisa; Stefani, Annalisa; Marinelli, Lieta; Gabai, Gianfranco

doi:10.1007/s11357-015-9778-9

Cited by 8 publications

(11 citation statements)

References 56 publications

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“…In healthy beagle dogs, the numbers of CD4+ CD45+ and CD8+ CD45RA+ lymphocytes significantly decrease with age [78]. Moreover, aged dogs display a greater neutrophil-to-lymphocyte ratio and lower CD21+ B cells [79].…”

Section: Inflammation Leukocyte Recruitment and Activationmentioning

confidence: 99%

“…Therefore, studies performed in groups of dogs belonging to the same breed, such as the experimental beagle, may show differences in OS biomarkers [93]. Conversely, studies performed in populations of heterogeneous pet dogs may fail to detect differences in OS biomarkers between adult and aged dogs [79,94]. Moreover, the lifestyle of the subjects, in particular the different nutritional habits, can have a substantial impact on the degree of OS [79].…”

Section: Inflammation Leukocyte Recruitment and Activationmentioning

confidence: 99%

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Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest

et al. 2019

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In the veterinary sector, many papers deal with the relationships between inflammation and oxidative stress. However, few studies investigate the mechanisms of action of oxidised molecules in the regulation of immune cells. Thus, authors often assume that these events, sometime leading to oxidative stress, are conserved among species. The aim of this review is to draw the state-of-the-art of the current knowledge about the role of oxidised molecules and dietary antioxidant compounds in the regulation of the immune cell functions and suggest some perspectives for future investigations in animals of veterinary interest.

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Section: Inflammation Leukocyte Recruitment and Activationmentioning

confidence: 99%

Section: Inflammation Leukocyte Recruitment and Activationmentioning

confidence: 99%

Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest

et al. 2019

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“…In aged canines, immunotherapy designed to reduce amyloid β (Aβ) pathology also improved cognitive function in the assessed tasks [112]. Mongillo et al [113] reported a higher monocyte count and percentage in cognitively impaired aged dogs compared with aged dogs with no cognitive impairment. These studies indicate that pro-inflammatory markers are associated with a decline in cognitive function.…”

Section: Cognitive Functionmentioning

confidence: 99%

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

Panickar¹,

Jewell²

2015

Hormone Molecular Biology and Clinical Investigation

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Aging in humans is associated with chronic low-grade inflammation (systemic), and this condition is sometimes referred to as "inflammaging". In general, canines also age similarly to humans, and such aging is associated with a decline in mobility, joint problems, weakened muscles and bones, reduced lean body mass, cancer, increased dermatological problems, decline in cognitive ability, reduced energy, decreased immune function, decreased renal function, and urinary incontinence. Each of these conditions is also associated with an increase in pro-inflammatory cytokines. An inflammatory state characterized by an increase in pro-inflammatory markers including but not restricted to tumor necrosis factor-α, interleukin-6, IL-1β, and C-reactive protein (CRP) is believed to contribute to or worsen a general decline in biological mechanisms responsible for physical function with aging. Nutritional management of inflammation in aging dogs is important in maintaining health. In particular, natural botanicals have bioactive components that appear to have robust anti-inflammatory effects and, when included in the diet, may contribute to a reduction in inflammation. While there are scientific data to support the anti-inflammatory effects and the efficacy of such bioactive molecules from botanicals, the clinical data are limited and more studies are needed to validate the efficacy of these ingredients. This review will summarize the role of dietary ingredients in reducing inflammatory molecules as well as review the evidence available to support the role of diet and nutrition in reducing chronic low-grade systemic inflammation in animal and human studies with a special reference to canines, where possible.

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“…Query: Please check the presentation of journal title of Ref. "Mongillo et al, 2015". Answer: The journal title is correct (Age), although the journal has recently changed its name to GeroScience…”

Section: Queries and Answersmentioning

confidence: 99%

“…Maze paradigms represent a valid tool in canine models to study the functions involved in spatial navigation (Craig et al, 2012;Macpherson and Roberts, 2010;Mongillo et al, 2015Mongillo et al, , 2013Parson et al, 2016) and the plusmaze has been proved one of the most effective type to assess navigation strategies both in humans and laboratory animals (Harris et al, 2012;Packard, 2009). A previous study performed by our research group demonstrated the feasibility of a T-maze paradigm to study spatial learning, long term memory and reversal learning (i.e.…”

mentioning

confidence: 99%

The effect of age, sex and gonadectomy on dogs’ use of spatial navigation strategies

Scandurra

Marinelli

Lõoke

et al. 2018

Applied Animal Behaviour Science

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Spatial navigation entails cognitive processes that allow mobile animals to know where they are and to find a way back to their shelters, or to access resources, by using multiple cue sources, such as path integration, magnetic cues and different landmarks (Brodbeck and Tanninen, 2012). The spatial cognitive processing requires memorizing specific landmarks, positions and locations, allowing, in its most sophisticated form, to elaborate a cognitive map in order to orientate oneself and navigate in the surrounding environment. In the last decades, a body of researches underlined sex differences in spatial navigation tasks in mammals with males showing generally better performances, possibly due to a different involvement in the reproductive function (

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Peripheral leukocyte populations and oxidative stress biomarkers in aged dogs showing impaired cognitive abilities

Cited by 8 publications

References 56 publications

Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest

Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

The effect of age, sex and gonadectomy on dogs’ use of spatial navigation strategies

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