Peripheral inflammatory and fibrinolytic markers in adolescents with growth hormone deficiency: Relation to postprandial dyslipidemia

Lanes, Roberto; Paoli, Mariela; Carrillo, Eduardo; Villaroel, Omar; Palacios, Anselmo

doi:10.1016/j.jpeds.2004.07.037

Cited by 30 publications

(30 citation statements)

References 23 publications

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“…Recent studies have suggested a strong link between inflammatory markers and atherosclerosis, so that CRP and interleukin-6 correlate with markers of endothelial dysfunction and CRP has been found to be a strong predictor of cardiovascular events. Increased production of IL-6 and TNF-α from monocytes and increased peripheral serum concentrations of CRP and IL-6 were found in adult GHD patients [16, 17] and elevated serum levels of CRP, TNF-α and fibrinogen were also recently reported by us in GHD adolescents [9]. In response to the generation of proinflammatory cytokines, vascular endothelial cells express several glycoproteins including the adhesion molecules E-selectin and ICAM-1 which facilitate the atherogenic process [28].…”

Section: Discussionmentioning

confidence: 81%

“…Increased visceral adiposity [3, 4], disturbances in lipoprotein metabolism [4, 5], premature atherosclerosis [6, 7], impaired fibrinolytic activity [8, 9], increased peripheral insulin resistance [10], hypoadiponectinemia [11], abnormal cardiac structure and impaired cardiac performance [12,13,14,15] have been reported in GHD adults and adolescents.…”

Section: Introductionmentioning

confidence: 99%

“…Inflammation plays an important role in the atherosclerotic process of the arterial wall and peripheral markers of inflammatory activity such as C-reactive protein (CRP), TNF-α and interleukin-6 have been shown to correlate with the risk of atherosclerosis in adults [16] and adolescents with GHD [9] and to be independently associated with the degree of common carotid artery intima-media thickness (IMT) in GHD adults [17]. In two recent studies in GHD adolescents, Colao et al [18] and ourselves [14] were unable to find a significant increase in the IMT of the carotid arteries in untreated GHD adolescents, although a tendency towards such an increase was noted in both these studies, while Kostro et al [19] found carotid artery IMT values to be significantly higher in GHD versus healthy children.…”

Section: Introductionmentioning

confidence: 99%

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Circulating Levels of High-Sensitivity C-Reactive Protein and Soluble Markers of Vascular Endothelial Cell Activation in Growth Hormone-Deficient Adolescents

Lanes

Marcano²,

Villaroel³

et al. 2008

Horm Res Paediatr

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Background/Aims: Significant endothelial dysfunction as determined by lower flow-mediated vasodilation of the brachial artery was recently reported by us in growth hormone-deficient (GHD) adolescents. The circulating concentrations of markers of vascular endothelial cell and platelet activation and their relationship to inflammatory markers have not been previously evaluated in this group of patients. Objective: To assess the relationship between circulating levels of high-sensitivity C-reactive protein (CRP) and soluble markers of vascular endothelial cell activation in GHD adolescents. Design/Methods: Twenty-eight GHD children on GH treatment with a chronological age of 15.7 ± 2.6 years and 16 untreated GHD adolescents with a chronological age of 16.6 ± 3.3 years were studied. Concentrations of CRP, as an inflammatory marker, were measured in all patients and the association between CRP and the fasting soluble markers of vascular endothelial cell activation intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin and P-selectin levels was evaluated. Sixteen healthy adolescents with a mean chronological age of 15.1 ± 2.2 years served as controls. Results: CRP and P-selectin levels were significantly higher in untreated GHD adolescents than in treated GHD subjects or in healthy controls (p < 0.02), while VCAM-1 concentrations were increased in both untreated and treated GHD adolescents when compared to controls (p < 0.007). E-selectin and ICAM-1 levels were similar in all three groups. CRP was found to be associated with BMI (r: 0.62; p < 0.001), P-selectin (r: 0.43; p < 0.01), E-selectin (r: 0.27; p < 0.03), ICAM-1 (r: 0.23; p < 0.05) and VCAM-1 (r: 0.40; p < 0.001) concentrations in untreated GHD adolescents and with P-selectin (r: 0.88; p < 0.001) and E-selectin (r: 0.29; p < 0.01) in treated GHD subjects. A weak inverse association was observed in a subgroup of patients between brachial artery endothelium-dependent dilation and P-selectin (r: –0.56; p < 0.07). Conclusions: Low-grade inflammation as manifested by increased circulating levels of CRP seems to be associated with the early activation of vascular endothelial cells in GHD adolescents

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circulating Levels of High-Sensitivity C-Reactive Protein and Soluble Markers of Vascular Endothelial Cell Activation in Growth Hormone-Deficient Adolescents

Lanes

Marcano²,

Villaroel³

et al. 2008

Horm Res Paediatr

Self Cite

View full text Add to dashboard Cite

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“…Currently, there is limited data available regarding the presence of peripheral inflammatory markers and its contribution to future cardiovascular disease in GH deficient adolescents and children. Lanes et al compared cytokine levels in a population of untreated GH deficient adolescents, treated GH deficient adolescents and healthy controls [16]. CRP, TNF α, and fibrinogen levels were equally elevated in all adolescents with GH deficiency suggesting the inflammatory response may begin as early as adolescence and may not be reduced with GH supplementation [16].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing

Tafuri¹,

Dixon²,

Markarian³

et al. 2015

IJCM

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Background: The relationship between growth hormone (GH) and cytokines remains unclear. Several studies have suggested that GH increases tumor necrosis factor (TNF)-α production in both children and adults. However, a number of studies have demonstrated a negative correlation between GH and TNF α. The aim of this study is to explore the relationship between endogenous GH secretion and certain pro and anti-inflammatory cytokines in short children undergoing GH stimulation testing for evaluation for GH deficiency. Methods: Plasma growth hormone, TNF α, CRP, IL-6, IL1-β, IL-4 and IL-10 levels are obtained at baseline and every 30 minutes for 150 minutes following two provocative agents (clonidine, and either arginine or glucagon). Results: Among the 23 children, 7 are found to be GH deficient. No significant differences in baseline TNF α levels are found between GH deficient and GH sufficient children. No correlation is identified between TNF α levels and GH levels during stimulation testing. Furthermore, no relationship is found between GH and pro-inflammatory cytokines or GH and anti-inflammatory cytokines. Conclusion: Our results do not demonstrate an acute relationship between endogenous GH secretion and the cytokines examined.

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“…In the pediatric population, a few studies have been reported, some in adolescents with GHD, finding elevated CRP and fibrinogen levels [16,22,23,24]; however, less studies were conducted in prepubertal children with the identification of high levels of fibrinogen, CRP and homocysteine [11,16,17,25]. Of note, in all these studies, the biochemical parameters were reversed by short-term r-hGH therapy.…”

Section: Biochemical Alterations and The Effect Of R-hgh Therapymentioning

confidence: 99%

Growth Hormone Deficiency in Prepubertal Children: Predictive Markers of Cardiovascular Disease

Leonibus¹,

Marco²,

Stevens³

et al. 2016

Horm Res Paediatr

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Background: Cardiovascular (CV) risk factors have been identified in adults with untreated growth hormone deficiency (GHD). Existing evidence suggests that the development of the atheromatous plaque begins early in childhood. Previous reports have shown that GHD children are prone to increased CV risks including impaired cardiac function, dyslipidemia and abnormalities in body composition. Recent studies in epigenetics and metabolomics have defined specific fingerprints that might be associated with an increased risk of CV disease. Aim: The aim of this review is to point out the most significant biochemical and clinical predictive markers of CV disease in prepubertal children and to evaluate the effect of recombinant human growth hormone therapy on most of these alterations. The novel findings in epigenetics and metabolomics are also reviewed, with a particular focus on translating them into clinical practice.

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Peripheral inflammatory and fibrinolytic markers in adolescents with growth hormone deficiency: Relation to postprandial dyslipidemia

Cited by 30 publications

References 23 publications

Circulating Levels of High-Sensitivity C-Reactive Protein and Soluble Markers of Vascular Endothelial Cell Activation in Growth Hormone-Deficient Adolescents

Circulating Levels of High-Sensitivity C-Reactive Protein and Soluble Markers of Vascular Endothelial Cell Activation in Growth Hormone-Deficient Adolescents

Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing

Growth Hormone Deficiency in Prepubertal Children: Predictive Markers of Cardiovascular Disease

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