Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state

Zheng, Jian; Zhu, Li; Ju, Bomiao; Zhang, Jing; Wang, Yanhua; Lv, Xiaoyi; Pu, Dan; Wang, Jing

doi:10.1016/j.clim.2022.109166

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…The present study was performed in an attempt to estimate a possible correlation between T cell immunity and DN B lymphocytes in patients with SLE. DN B cells consist of a certain subpopulation, which is significantly increased in the elderly but also in several chronic inflammatory diseases, including SLE [ 7 , 11 , 16 , 17 , 18 ]. Their origin, function, and differential status is still unclear, as they carry characteristics of both naïve, switched memory, and immune-exhausted cells [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…SLE, as well as other systemic autoimmune diseases, is associated with a significant increase in DN B lymphocytes, both DN1 and DN2. From those, DN2 B cells are most important, as they act as antigen-presenting cells and stimulate T cell response, differentiate into antibody and cytokine-secreting cells, and modulate immune response, sustained autoimmunity, and inflammation [ 16 , 17 , 18 , 19 ]. DN2 B lymphocytes share similar characteristics with naïve B lymphocytes, such as the absence of CXCR5, CD24, and CD38 surface molecules, which are common in the rest of peripheral B lymphocyte subsets, but also retain a unique phenotype, expressing CD69, HLA-DR, CD86, and the regulatory receptors CD32b and CD22, and lacking the lymph node homing receptor L-selectin (CD62L) [ 7 , 9 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Increase in Double Negative B Lymphocytes in Patients with Systemic Lupus Erythematosus in Remission and Their Correlation with Early Differentiated T Lymphocyte Subpopulations

Moysidou,

Lioulios,

Christodoulou

et al. 2023

CIMB

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B and T lymphocytes demonstrate important alterations in patients with systemic lupus erythematous (SLE), with a significant upregulation of double negative (DN) B cells. The aim of this study was to evaluate the correlation of T cell immunity changes with the distinct B-cell-pattern SLE. In the present study, flow cytometry was performed in 30 patients in remission of SLE and 31 healthy controls to detect DN B cells (CD19+IgD-CD27-) and a wide range of T lymphocyte subpopulations based on the presence of CD45RA, CCR7, CD31, CD28, and CD57, defined as naive, memory, and advanced differentiated/senescent T cells. Both B and T lymphocytes were significantly reduced in SLE patients. However, the percentage of DN B cells were increased compared to HC (12.9 (2.3–74.2) vs. 8 (1.7–35), p = 0.04). The distribution of CD4 and CD8 lymphocytes demonstrated a shift to advanced differentiated subsets. The population of DN B cells had a significant positive correlation with most of the early differentiated T lymphocytes, CD4CD31+, CD4CD45RA+CD28+, CD4CD45RA+CD57-, CD4CD45RA-CD57-, CD4CD28+CD57-, CD4CD28+CD57+, CD4 CM, CD8 CD31+, CD8 NAÏVE, CD8CD45RA-CD57-, CD8CD28+CD57-, and CD8CD28+CD57+. Multiple regression analysis revealed CD4CD31+, CD8CD45RA-CD57-, and CD8CD28+CD57- cells as independent parameters contributing to DN B cells, with adjusted R2 = 0.534 and p < 0.0001. The predominance of DN B cells in patients with SLE is closely associated with early differentiated T lymphocyte subsets, indicating a potential causality role of DN B cells in T lymphocyte activation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Increase in Double Negative B Lymphocytes in Patients with Systemic Lupus Erythematosus in Remission and Their Correlation with Early Differentiated T Lymphocyte Subpopulations

Moysidou,

Lioulios,

Christodoulou

et al. 2023

CIMB

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“…The pathogenesis of SLE is likely based on genetic susceptibility factors of the body due to infection, ultraviolet (UV) irradiation, and other factors, inducing immune disorders that result in an abnormal activation of autoreactive T and B lymphocytes, the production of a large number of autoantibodies, immune complex formation and deposition, which lead to deregulated inflammation and multiorgan injuries ( George and Tsokos, 2011 ; Lech and Anders, 2013 ; Marianthi Kiriakidou and Cathy Lee Ching, 2020 ). Jian Zheng ( Zheng et al, 2022 )analyzed the B and T cell subsets comparing SLE patients in the low activity phase and healthy controls, and the T and B cell axes showed abnormalities, and the proportion of double negative B cells and CD8 + T cells was significantly reduced, the results indicated that the immune phenotype and the incidence of the disease were closely related. Autophagy affects the pathogenesis of SLE in many ways.…”

Section: Autophagy and Immunological Aberrations In Slementioning

confidence: 99%

Perturbed autophagy intervenes systemic lupus erythematosus by active ingredients of traditional Chinese medicine

Tian

Yuan²,

Huang³

et al. 2023

Front. Pharmacol.

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Systemic lupus erythematosus (SLE) is a common multisystem, multiorgan heterozygous autoimmune disease. The main pathological features of the disease are autoantibody production and immune complex deposition. Autophagy is an important mechanism to maintain cell homeostasis. Autophagy functional abnormalities lead to the accumulation of apoptosis and induce the autoantibodies that result in immune disorders. Therefore, improving autophagy may alleviate the development of SLE. For SLE, glucocorticoids or immunosuppressive agents are commonly used in clinical treatment, but long-term use of these drugs causes serious side effects in humans. Immunosuppressive agents are expensive. Traditional Chinese medicines (TCMs) are widely used for immune diseases due to their low toxicity and few side effects. Many recent studies found that TCM and its active ingredients affected the pathological development of SLE by regulating autophagy. This article explains how autophagy interferes with immune system homeostasis and participates in the occurrence and development of SLE. It also summarizes several studies on TCM-regulated autophagy intervention in SLE to generate new ideas for basic research, the development of novel medications, and the clinical treatment of SLE.

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Application of Machine Learning Models in Systemic Lupus Erythematosus

Ceccarelli

Natalucci

Picciariello

et al. 2023

IJMS

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Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease and is extremely heterogeneous in terms of immunological features and clinical manifestations. This complexity could result in a delay in the diagnosis and treatment introduction, with impacts on long-term outcomes. In this view, the application of innovative tools, such as machine learning models (MLMs), could be useful. Thus, the purpose of the present review is to provide the reader with information about the possible application of artificial intelligence in SLE patients from a medical perspective. To summarize, several studies have applied MLMs in large cohorts in different disease-related fields. In particular, the majority of studies focused on diagnosis and pathogenesis, disease-related manifestations, in particular Lupus Nephritis, outcomes and treatment. Nonetheless, some studies focused on peculiar features, such as pregnancy and quality of life. The review of published data demonstrated the proposal of several models with good performance, suggesting the possible application of MLMs in the SLE scenario.

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Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state

Cited by 3 publications

References 35 publications

Increase in Double Negative B Lymphocytes in Patients with Systemic Lupus Erythematosus in Remission and Their Correlation with Early Differentiated T Lymphocyte Subpopulations

Increase in Double Negative B Lymphocytes in Patients with Systemic Lupus Erythematosus in Remission and Their Correlation with Early Differentiated T Lymphocyte Subpopulations

Perturbed autophagy intervenes systemic lupus erythematosus by active ingredients of traditional Chinese medicine

Application of Machine Learning Models in Systemic Lupus Erythematosus

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