Peripheral hypoxia in restless legs syndrome (Willis-Ekbom disease)

Salminen, Aaro V.; Rimpilä, Ville; Polo, O.

doi:10.1212/wnl.0000000000000454

Cited by 104 publications

(47 citation statements)

References 30 publications

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“…The activation of the hypoxic pathway of cellular metabolism has therefore been proposed as a potential mechanism behind dopaminergic dysfunction and RLS symptomatology. Other studies have demonstrated a lower transcutaneous oxygen pressure in the legs of patients with RLS which was reversed by the dopamine agonist pramipexole [10]. These pathophysiological mechanisms in RLS provide a potential link to tissue hypoxia caused by chronic pulmonary disease and may explain the associations demonstrated in the current epidemiological study.…”

Section: Discussionsupporting

confidence: 59%

Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women—a population-based study

et al. 2018

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Introduction Recent studies suggest an increased prevalence of chronic pain conditions and restless legs syndrome (RLS) in patients with chronic pulmonary disease (CPD). We analyzed the prevalence and risk factors for pain and RLS in a populationbased sample of females with comorbid CPD. Method Questionnaire-based data from 2745 women aged 18-64 years were analyzed regarding comorbid CPD status (severe bronchitis, emphysema, asthma). Pain status was assessed according to symptoms reflecting severity (Visual Analogue Scale, VAS rating 0-10) and duration and spreading (limited spread or widespread) of pain. A diagnosis of RLS was defined by four validated diagnostic criteria. Anthropometrics and co-morbidities were assessed as covariates in univariate and multivariate analyses. Results Widespread pain was overrepresented in women with CPD (44.6 vs. 24.6%, p < 0.001). The odds ratio for widespread pain in women with CPD was 1.6 (95% confidence interval (CI) 1.2-2.2, p < 0.001) in the fully adjusted model. Severe pain (VAS rating ≥ 7) was more prevalent in females with known CPD (28.8 vs. 15.4%, p < 0.001, odd ratio 1.4 (95% CI 1.0-1.9, p = 0.029)). The prevalence of RLS was 37.4 and 23.8% in subjects with or without CPD, respectively (p < 0.001). In multivariate analysis, CPD was associated with a 30% risk increase for RLS (odds ratio 1.3 (95% CI 1.0-1.7, p = 0.04)). Conclusion This population-based study identified CPD as an independent risk factor for severe and widespread pain as well as for RLS. Further research addressing pathophysiological mechanisms linking CPD and chronic pain conditions/ RLS is warranted.

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Section: Discussionsupporting

confidence: 59%

Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women—a population-based study

et al. 2018

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“…87 Salminen et al found a correlation of worse peripheral hypoxemia with RLS severity, and reversal of hypoxemia with pramipexole treatment, supporting the hypothesis that peripheral vascular systems are involved in RLS pathophysiology. 88 However, a subsequent study could not confirm the hypothesis of impaired microcirculation in RLS patients. The authors postulated that findings in prior studies of altered blood flow and microcirculation may be related to a dopaminergic treatment effect, rather than RLS.…”

Section: Hypoxia and Impaired Microcirculationmentioning

confidence: 88%

Cardiovascular comorbidity in patients with restless legs syndrome: current perspectives

Vargas-Pérez¹,

Bagai²,

Walters³

2017

JPRLS

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“…Indeed, peripheral hypoxia and low oxygen pressure in resting and immobilized subjects is associated with the appearance of RLS symptoms. 48 First, RLS is prevalent in various respiratory conditions including asthma, emphysema, bronchiolitis, 38 and recipients of lung transplants, 49 and the incidence is as high as 50% during acute exacerbations of chronic obstructive lung disease. 50,51 Second, patients suffering from coronary artery disease and heart failure often experience RLS, 52 with questionable participation of sympathetic hyperactivity in PLM.…”

Section: Associated Disordersmentioning

confidence: 99%