Peripheral glutamate and TNF-α levels in patients with intracerebral hemorrhage: Their prognostic values and interactions toward the formation of the edemal volume

Rendevski, Vladimir; Aleksovski, Boris; Stojanov, Dragan; Aleksovski, Vasko; Rendevska, Ana Mihajlovska; Kolevska, Milena; Стојаноски, Киро; Gjorgoski, Icko

doi:10.1016/j.pjnns.2017.10.003

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…At admission (during the first 4 h post ICH‐onset), patient's age, sex, blood pressure, heart rate and previous diagnosed diseases were recorded, their neurological state at admission was evaluated in details and, scored by the Canadian Stroke Scale (CSS). Additionally, the first CT scan was performed at admission, and the anatomic localization and hemispheric side of the ICH was recorded; the initial volume of the hematoma was also assessed by the formula V = A × B × C/2, as previously described [ 7 ]. The second CT scan was performed on the 5th day (app.…”

Section: Methodsmentioning

confidence: 99%

“…120 ± 2 h post‐ICH), and the volumes of the hematoma and the perifocal edema were calculated. The edema was defined as the most hypodense area immediately surrounding the ICH and more hypodense than the corresponding area in the contralateral hemisphere; the volume of the edema was determined by subtracting the volume of the ICH from that of the total lesion, as previously described [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

“…Hence, aiming at prevention of formation of large edema volumes in patients after ICH, several studies up to now focused on its prediction. Most of these studies point out to the primary role of inflammatory mechanisms in the formation of large edema volumes; for instance, our previous work stressed the importance of TNF‐α, a pro‐inflammatory cytokine, in the formation of the brain edema [ 7 ], as well as its role in prediction of the 3‐month functional outcome [ 8 ]. Nevertheless, the data concerning the role of other cytokines in brain edema formation and functional outcome after ICH is scarce.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume

et al. 2022

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We aimed to analyze the inflammatory and oxidative stress (OS) markers after intracerebral hemorrhage (ICH) and their temporal changes, interaction effects, and prognostic values as biomarkers for the prediction of the edema volume. Our prospective, longitudinal study included a cohort group of 73 conservatively treated patients with ICH, without hematoma expansion or intraventricular bleeding, which were initialized with the same treatment and provided with the same in-hospital care during the disease course. Study procedures included multilevel comprehensive analyses of clinical and neuroimaging data, aligned with the exploration of 19 inflammatory and five OS markers. White blood cells (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophilia, and lymphopenia peaked 3 days post-ICH, and they showed much stronger correlations with clinical and neuroimaging variables, when compared to the admission values. An intricate interplay among inflammatory (WBC, CRP, neutrophils, neutrophil-to-lymphocyte ratio [NLR], interleukin (IL)-6, and IL-10) and OS mechanisms (catalase activity and advanced oxidation protein products [AOPP]) was detected operating 3-days post-ICH, being assessed as relevant for prediction of the edema. The overall results suggested complex pathology of formation of post-ICH edema, via: (A) Not additive, but statistically significant synergistic interactions between CRP-ESR, neutrophils-CRP, and neutrophils-IL-6 as drivers for the edema formation; (B) Significant antagonistic effect of high protein oxidation on the CRP-edema dependence, suggesting a mechanism of potential OS-CRP negative feedback loop and redox inactivation of CRP. The final multiple regression model separated the third-day variables NLR, CRP Â AOPP, and WBC, as significant prognostic biomarkers for the prediction of the edema volume, with NLR being associated with the highest effect size. Our developed mathematical equation with 3D modeling for prediction and quantification of the edema volume might be beneficial for taking timely adequate strategies for prevention of delayed neurological deteriorations.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume

et al. 2022

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“…The study by Rendevski et al [29] of our research group aimed to evaluate the role of peripheral plasma glutamate and TNF-α levels as biomarkers for ICH. Furthermore, to examine the prognostic role and possible interactions of these variables in the development of edema volume 5 days after ICH.…”

Section: The Role Of Glutamate In Pathological Conditions: a Focus On...mentioning

confidence: 99%

The role of glutamate in pathogenesis of brain edema in intracerebral hemorrhage

Rendevski,

Aleksovski

2024

Two Sides of the Same Coin - Glutamate in Health and Disease [Working Title]

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This chapter is dedicated to the impressing molecule of glutamamte—both an amino acid and a major excitatory neurotransmitter in the brain. The chapter focuses scientific on review of our work in the past decade, stressing the role of glutamate excitotoxicity as significant and sensitive biomarker for quantification of the volume of brain edema in intracerebral hemorrhage, which is important in the trajectory of clinical deterioration. We explain several developed mathematical models based on multiple regression analysis for the purposes of prognostication and potential clinical implications. These mathematical models can contribute to clinical decision making and resolving the dilemma between conservative and operative treatment in patients with hemorrhagic stroke, especially in the first 4–5 days.

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“…Either Hemo or radiation injury (RI) can result in similar outcomes depending on the % of blood loss or the radiation dose. Hemo at 40% of total blood volume, which was classified as level 4 damage [ 16 ], increases the concentrations of interleukin-10 (IL-10) and tumor necrotic factor-α (TNF-α) in blood, activates nuclear factor-keppaB (NF-κB) and inducible nitric oxide synthase (iNOS) expression in the murine small intestine, and increases cell apoptosis in various murine tissues [ 17 , 18 , 19 , 20 ]. Likewise, sub-lethal ionizing radiation also increases these parameters [ 4 ] in addition to initiating deleterious hematopoietic changes [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Hemorrhage on Hematopoietic Cell Depletion after a Combined Injury with Radiation: Role of White Blood Cells and Red Blood Cells as Biomarkers

Kiang,

Woods,

Cannon

2024

IJMS

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Combined radiation with hemorrhage (combined injury, CI) exacerbates hematopoietic acute radiation syndrome and mortality compared to radiation alone (RI). We evaluated the effects of RI or CI on blood cell depletion as a biomarker to differentiate the two. Male CD2F1 mice were exposed to 8.75 Gy γ-radiation (60Co). Within 2 h of RI, animals were bled under anesthesia 0% (RI) or 20% (CI) of total blood volume. Blood samples were collected at 4–5 h and days 1, 2, 3, 7, and 15 after RI. CI decreased WBC at 4–5 h and continued to decrease it until day 3; counts then stayed at the nadir up to day 15. CI decreased neutrophils, lymphocytes, monocytes, eosinophils, and basophils more than RI on day 1 or day 2. CI decreased RBCs, hemoglobin, and hematocrit on days 7 and 15 more than RI, whereas hemorrhage alone returned to the baseline on days 7 and 15. RBCs depleted after CI faster than post-RI. Hemorrhage alone increased platelet counts on days 2, 3, and 7, which returned to the baseline on day 15. Our data suggest that WBC depletion may be a potential biomarker within 2 days post-RI and post-CI and RBC depletion after 3 days post-RI and post-CI. For hemorrhage alone, neutrophil counts at 4–5 h and platelets for day 2 through day 7 can be used as a tool for confirmation.

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Peripheral glutamate and TNF-α levels in patients with intracerebral hemorrhage: Their prognostic values and interactions toward the formation of the edemal volume

Cited by 7 publications

References 36 publications

Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume

Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume

The role of glutamate in pathogenesis of brain edema in intracerebral hemorrhage

Effects of Hemorrhage on Hematopoietic Cell Depletion after a Combined Injury with Radiation: Role of White Blood Cells and Red Blood Cells as Biomarkers

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