Peripheral Glucose Metabolism in Patients with Essential Hypertension

Gouveia, L. M. F. B.; Paccola, G M G F; Torquato, M T C G; Menezes, Flavia; Piccinato, Carlos Eli; Foss, Milton César

doi:10.1055/s-2007-978583

Cited by 7 publications

(9 citation statements)

References 8 publications

(8 reference statements)

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“…Serum free fatty acid levels were similar for the two groups (Table 1), possibly reflecting a differential effect on the various actions of insulin, as previously observed in situations of insulin resistance and in human arterial hypertension itself (2).…”

Section: Discussionsupporting

confidence: 78%

“…As previously demonstrated by our group in individuals with arterial hypertension, this alteration is due to a lower glucose uptake by muscle tissue and to a lower utilization of this substrate in intracellular non-oxidative metabolism (2).…”

Section: Discussionsupporting

confidence: 52%

“…Abnormalities in glucose metabolism and in peripheral tissue sensitivity to the action of insulin have been reported for patients with arterial hypertension (1,2). Epidemiological evidence has supported the hypothesis which proposes the existence of a syndrome in which hyperinsulinemia may precede the development of arterial hypertension and changes in glucose and lipid metabolism (3)(4)(5).…”

Section: Introductionmentioning

confidence: 94%

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Abnormalities of glucose metabolism in spontaneously hypertensive rats

Gouveia

Kettelhut

Foss

2000

Braz J Med Biol Res

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Abnormalities in glucose metabolism and insulin action are frequently detected in patients with essential hypertension. Spontaneously hypertensive rats (SHR) have been used as an experimental model to understand this pathological condition. The objective of the present study was to assess glucose metabolism and insulin action in SHR and Wistar rats under fed and fasting conditions. Peripheral glucose utilization was estimated by kinetic studies with [6-3 H]-glucose and gluconeogenetic activity was measured during continuous [ 14 C]-bicarbonate infusion. Plasma glucose levels were higher in the SHR group. Plasma insulin levels in the fed state were higher in the SHR group (99.8 ± 6.5 µM) than in the control group (70.4 ± 3.6 µM). Muscle glycogen content was reduced in SHR compared to control under the various experimental conditions. Peripheral glucose utilization was slightly lower in the SHR group in the fed state (8.72 ± 0.55 vs 9.52 ± 0.80 mg kg -1 min -1 in controls). Serum free fatty acid levels, hepatic glycogen levels, hepatic phosphoenolpyruvate carboxykinase activity and gluconeogenetic activity were similar in the two groups. The presence of hyperglycemia and hyperinsulinemia and the slightly reduced peripheral glucose utilization suggest the presence of resistance to the action of insulin in peripheral tissues of SHR. Hepatic gluconeogenesis does not seem to contribute to the metabolic alterations detected in these animals.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 94%

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Abnormalities of glucose metabolism in spontaneously hypertensive rats

Gouveia

Kettelhut

Foss

2000

Braz J Med Biol Res

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“…Interestingly, glucose intolerance and insulin resistance have been recently reported for patients with hypertension [6]. Moreover, there is a growing body of evidence that indicates a shift in myocardial energy substrate preference from LCFA to glucose in hypertension [7, 8].…”

Section: Introductionmentioning

confidence: 99%

The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension

Polak

Harasim-Symbor

Malinowska

et al. 2018

Cell Physiol Biochem

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Background/Aims: Recent interest in the use of cannabinoids as therapeutic agents has revealed the involvement of the endogenous cannabinoid system (ECS) in the regulation of the cardiovascular system in hypertension. Abnormalities in glucose metabolism and insulin action are commonly detected in hypertensive animals. Thus, potential antihypertensive drugs should be investigated with respect to modulation of glucose homeostasis. Therefore, the aim of the present study was to evaluate the effects of the ECS activation after chronic fatty acid amide hydrolase inhibitor (URB597) administration on plasma glucose and insulin concentrations as well as parameters of myocardial glucose metabolism in the deoxycorticosterone acetate (DOCA)-salt hypertensive rats, an animal model of secondary hypertension. Methods: Hypertension was induced by DOCA (25mg/kg) injections and addition of 1% NaCl in the drinking water for six weeks. Chronic activation of the ECS was performed by URB597 (1mg/kg) injections for two weeks. We examined fasting plasma levels of insulin (ELISA), glucose and intramyocardial glycogen (colorimetric method). Expressions of glucose transporters (GLUT1, 4) and selected proteins engaged in GLUT translocation as well as glucose metabolism were determined using Western blotting. Results: Hypertension induced hypoinsulinemia with concomitant lack of significant changes in glycemia, reduced intramyocardial glycogen content and increased pyruvate dehydrogenase (PDH) expression in the cardiac muscle. Importantly, chronic URB597 administration in the hypertensive rats increased insulin concentration, elevated plasmalemmal GLUT1 and GLUT4 expression and concomitantly improved myocardial glycogen storage. Conclusion: Chronic administration of fatty acid amide hydrolase (FAAH) inhibitor has potential protective properties on myocardial glucose metabolism in hypertension.

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“…The euglycemic hyperinsulinemic clamp technique is the reference and best method for quantifying insulin sensitivity or resistance in vivo because it directly measures the effects of insulin on glucose utilization under steady state conditions (6). In contrast, the forearm technique to estimate muscle glucose metabolism combined or not with indirect calorimetry directly analyzes the biological action of insulin on a metabolically active tissue, the muscle, and represents a good method to evaluate insulin sensitivity or resistance (9)(10)(11)(12)(13)(14)(15)(16). However, these methods are not easily applied in large-scale or routine clinical investigations because they are laborious and expensive.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the homeostasis model assessment and quantitative insulin sensitivity check index with data from forearm metabolic studies for the in vivo assessment of insulin sensitivity

Foss-Freitas

Foss

2004

Braz J Med Biol Res

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The present study was designed to compare the homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI) with data from forearm metabolic studies of healthy individuals and of subjects in various pathological states. Fifty-five healthy individuals and 112 patients in various pathological states, including type 2 diabetes mellitus, essential hypertension and others, were studied after an overnight fast and for 3 h after ingestion of 75 g of glucose, by HOMA, QUICKI and the forearm technique to estimate muscle uptake of glucose combined with indirect calorimetry (oxidative and non-oxidative glucose metabolism). The patients showed increased HOMA (1.88 ± 0.14 vs 1.13 ± 0.10 pmol/l x mmol/l) and insulin/glucose (I/G) index (1.058.9 ± 340.9 vs 518.6 ± 70.7 pmol/l x (mg/100 ml forearm) -1 ), and decreased QUICKI (0.36 ± 0.004 vs 0.39 ± 0.006 (µU/ml + mg/dl) -1 ) compared with the healthy individuals. Analysis of the data for the group as a whole (patients and healthy individuals) showed that the estimate of insulin resistance by HOMA was correlated with data obtained in the forearm metabolic studies (glucose uptake: r = -0.16, P = 0.04; non-oxidative glucose metabolism: r = -0.20. P = 0.01, and I/G index: r = 0.17, P = 0.03). The comparison of QUICKI with data of the forearm metabolic studies showed significant correlation between QUICKI and non-oxidative glucose metabolism (r = 0.17, P = 0.03) or I/G index (r = -0.37, P < 0.0001). The HOMA and QUICKI are good estimates of insulin sensitivity as data derived from forearm metabolic studies involving direct measurements of insulin action on muscle glucose metabolism.

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Peripheral Glucose Metabolism in Patients with Essential Hypertension

Cited by 7 publications

References 8 publications

Abnormalities of glucose metabolism in spontaneously hypertensive rats

Abnormalities of glucose metabolism in spontaneously hypertensive rats

The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension

Comparison of the homeostasis model assessment and quantitative insulin sensitivity check index with data from forearm metabolic studies for the in vivo assessment of insulin sensitivity

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