Peripheral giant cell granuloma: a clinical study of 77 cases from 62 patients, and literature review

Abstract

OBJECTIVES: The aim of this study was to identify the principle clinical features of the peripheral giant cell granuloma (PGCG), and to recognise clinical features of PGCG that are poorly defined. DESIGN: We reviewed retrospectivety 77 cases of PGCG from 62 patients, from our files with respect to incidence, sex, patient age, race, clinical symptoms and signs, radio‐graphic features and recurrence following excision. RESULTS AND CONCLUSIONS: Our results were largety in agreement with previous reports, although there is wide variation in the results published between series. In addition, some clinical features of PGCG are poorly defined. Little is known about the retative incidences of PGCG and central giant cell granuloma. An association between PGCG and tooth loss may exist, but is poorly defined, and not all PGCG that involve edentulous areas follow recent tooth loss. Information about PGCG recurrence after excision is limited, and does not necessarily follow incomplete excision. Despite the large number of reported cases of PGCG, clarification of some clinical features is required, and may hetp formulation and interpretation of future laboratory‐based research into this poorly understood lesion.

A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

“…In the present study, PGCGs appeared more common in males, which is in contrast to the proved thesis that de-scribes predilection for female patients 3,9,11,[14][15][16] .Murat et al's also reported male predilection (56%) which was slightly higher than our results 17 . A mandible predominance (58.7%) was identified in our series, and is in agreement with other studies 4,9,14,17 .…”

Clinical and Histologic Features of 26 Canine Peripheral Giant Cell Granulomas (Formerly Giant Cell Epulis)

“…25 In humans, peripheral giant cell granulomas are located predominantly in mandibular gingiva. 13,15 Marginal excision was usually curative in this study, with recurrence reported in only 2 cases, each within 2 months after excision. No histologic features distinguished the peripheral giant cell granulomas that recurred from those that did not.…”

“…5 Although no sex predisposition for peripheral giant cell granulomas has been reported for dogs or cats, there is a slight female predominance in human cases. 13,15 Peripheral giant cell granulomas are most often in maxillary gingiva, similar to fibromatous epulis, and in contrast to acanthomatous ameloblastoma, for which 58.8% arise around mandibular canine teeth. 25 In humans, peripheral giant cell granulomas are located predominantly in mandibular gingiva.…”

“…An association between periodontal disease and the development of peripheral giant cell granuloma has also been suggested in humans. 13,15 In dogs, fibromatous epulides of periodontal ligament origin are associated with more severe dental plaque deposition than are acanthomatous ameloblastomas and may develop in association with chronic inflammation. 25 The presence of periodontal disease in dogs with peripheral giant cell granuloma has not been previously reported, but no correlation was evident in this study.…”

Gingival Localized Reactive Lesions: A Demographic and Retrospective Study

“…1,[15][16][17] Ancak, üç ça-lışmada alt ve üst çeneler arasında eşit dağılım gözlenmiştir. 6,10,18 Çene içi yerleşim açısından ço-ğunlukla alt çene posterior bölge rapor edilmiş-tir. 6,9,16,17 Mevcut çalışmada da en çok (%50) görülen çene içi yerleşim alt çene posterior bölge-dir ve bu açıdan literatür ile uyumluluk göster-mektedir.…”