Peripheral facial paralysis as the only symptom revealing sars cov 2 infection: Case report

Taouihar, Salma; Bouabdallaoui, Amine; Aabdi, Mohammed; Kaouini, Abderrahim El; Aidouni, Ghizlane El; Merbouh, Manal; Zaid, Ikram; Bkiyar, Houssam; Housni, Brahim

doi:10.1016/j.amsu.2021.102550

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…The latter are mentioned among the probable causes of facial nerve ischemia in COVID-19; however, an inflammatory process cannot be ruled out either [59]. Isolated unilateral Bell's palsy in the context of atypical COVID-19 presentation was reported in the literature [60,61] with a delay of about 7-10 days between infection and the onset of neurological symptoms. In the cross-sectional study carried out on 41 patients with acute peripheral facial paralysis as the only symptom, almost one fourth obtained a positive SARS-CoV-2 IgG + IgM test [62].…”

Section: Discussionmentioning

confidence: 99%

Facial Diplegia—Complication or Manifestation of SARS-CoV-2 Infection? A Case Report and Systemic Literature Review

et al. 2021

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Since the outbreak of the new coronavirus, healthcare systems around the world have witnessed not only COVID-19 symptoms but also long-term complications of the aforementioned, including neurological problems. We report a clinical case of an adult patient with bilateral facial nerve palsy and progressive ascending paresis of the limbs after contracting the novel coronavirus (COVID-19). Additionally, the systematic review aimed to identify and summarize specific clinical features, outcomes and complications of the studies focusing on bilateral facial diplegia as a sequela of COVID-19 infection. The total number of analyzed patients was 15. Only one patient was diagnosed with isolated bilateral palsy; the rest had Guillain-Barré Syndrome (GBS). With one exception, all the presented cases had favorable outcomes, with facial palsy recovery from slight to almost complete. In patients with a confirmed COVID-19 diagnosis, bilateral facial palsy may be an isolated symptom as well as a variant of GBS. Symptoms of cranial nerve damage during a COVID-19 infection may explain the appearance of facial nerve damage. In order to clarify the spectrum of neurological manifestations and a causal relation between SARS-CoV-2, COVID-19 vaccination and neurological symptoms, direct attention towards the study of this virus is crucial. It seems reasonable to recognize human coronavirus as another potential GBS trigger.

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Section: Discussionmentioning

confidence: 99%

Facial Diplegia—Complication or Manifestation of SARS-CoV-2 Infection? A Case Report and Systemic Literature Review

et al. 2021

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“…Tools had 8 items for case reports and 10 for case series. Included case reports ( n = 39) had a mean score of 6.385 ± 1.41 with scores ranging from 2 to 8 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 10 case series had a mean score of 5.60 ± 2.01, and scores ranged from 3 to 9. 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 The detailed results of the quality assessment are provided in Supporting Information: File S1 .…”

Section: Methodsmentioning

confidence: 99%

“…Tools had 8 items for case reports and 10 for case series. Included case reports ( n = 39) had a mean score of 6.385 ± 1.41 with scores ranging from 2 to 8 12–50 10 case series had a mean score of 5.60 ± 2.01, and scores ranged from 3 to 9 51–59 . The detailed results of the quality assessment are provided in Supporting Information: File .…”

Section: Methodsmentioning

confidence: 99%

Facial palsy as a manifestation of COVID‐19: A systematic review of cases

Khurshid

Sohail

et al. 2022

Health Science Reports

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Background and Aims Facial palsy is a rare complication of the COVID‐19 infection. Herein, we conducted a systematic review of all published cases of facial palsy post‐COVID‐19 infection in an attempt to educate the general population and medical practitioners regarding the likely occurrence of facial palsy in COVID‐19 patients, its detection, effective treatment plan, and prognosis of the condition. Methods We searched PubMed, Google Scholar, and Directory of Open Access Journals (DOAJ) from December 1, 2019 to September 21, 2021. Results We included 49 studies bearing accounts of 75 cases who had facial palsy. The mean age of patients was 42.9 ± 19.59 years, with a male‐to‐female ratio of 8:7. The majority of the cases were reported from Brazil ( n = 14), USA ( n = 9), Turkey ( n = 9), and Spain ( n = 9). Noticeably, 30.14% of COVID‐19 patients were diagnosed with Guillain‐Barré syndrome. In total, 22.97% of patients complained of bilateral facial paralysis ( n = 17), whereas ipsilateral paralysis was observed in 77.03% ( n = 57). These were common complaints of Lagophthalmos, otalgia, facial drooping, dysarthria, and compromised forehead wrinkling. The treatment regimen mainly included the use of corticosteroids ( n = 51) (69.86%), antivirals ( n = 23) (31.51%), IVIG ( n = 18) (24.66%), antibiotics ( n = 13) (17.81%), antiretroviral ( n = 9) (12.33%), and antimalarial ( n = 8) (10.96%) medications. In all, 35.62% of patients ( n = 26) adhered to a combination of antiviral and corticosteroid‐based therapy. Positive treatment outcomes were observed in 83.58% ( n = 56) of cases. In contrast, 10 patients (14.93%) showed nonsignificant recovery, out of which 3 (4.48%) died from the disease. Conclusion The association of facial palsy with COVID‐19 is controversial and therefore requires further investigation and published work to confirm a causal relationship. However, physicians should not overlook the likelihood of facial palsy post‐COVID‐19 infection and treat it accordingly.

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“… Kerstens [ 44 ] Belgium Case report Emergency department April 2021 1 27 years M EBV, HSV, VZV Bilateral facial palsy associated with COVID-19. Taouihar [ 45 ] Morocco Case report University hospital center August, 2021 2 Patient 1: 39 years Patient 2: 57 years M (2) Serologies of HSV, HZV, HIV, Treponema pallidum hemagglutination assay (TPHA) were performed and came back negative SARS-CoV-2 viral infection. Ozer [ 46 ] Turkey Case report Clinic June 2021 1 62 years F Not reported PFP.…”

Section: Resultsmentioning

confidence: 99%

Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports

Cavalcante

Matos

Lima

et al. 2022

J. Venom. Anim. Toxins incl. Trop. Dis

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Peripheral facial paralysis (PFP) has been shown to be a neurological manifestation of COVID-19. The current study presents two cases of PFP after COVID-19, along with a rapid review of known cases in the literature. Both case reports were conducted following CARE guidelines. We also performed a systematic review of PFP cases temporally related to COVID-19 using PubMed, Embase, and Cochrane Library databases on August 30, 2021, using a rapid review methodology. The two patients experienced PFP 102 and 110 days after COVID-19 symptom onset. SARS-CoV-2 RNA was detected in nasal samples through reverse-transcription real-time polymerase chain reaction (RT-qPCR) testing. Anosmia was the only other neurological manifestation. PFP was treated with steroids in both cases, with complete subsequent recovery. In the rapid review, we identified 764 articles and included 43 studies. From those, 128 patients with PFP were analyzed, of whom 42.1% (54/128) were male, 39.06% (50/128) female, and in 23 cases the gender was not reported. The age range was 18 to 59 (54.68%). The median time between COVID-19 and PFP was three days (ranging from the first symptom of COVID-19 to 40 days after the acute phase of infection). Late PFP associated with COVID-19 presents mild symptoms and improves with time, with no identified predictors. Late PFP should be added to the spectrum of neurological manifestations associated with the long-term effects of SARS-CoV-2 infection as a post COVID-19 condition.

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Peripheral facial paralysis as the only symptom revealing sars cov 2 infection: Case report

Cited by 4 publications

References 5 publications

Facial Diplegia—Complication or Manifestation of SARS-CoV-2 Infection? A Case Report and Systemic Literature Review

Facial Diplegia—Complication or Manifestation of SARS-CoV-2 Infection? A Case Report and Systemic Literature Review

Facial palsy as a manifestation of COVID‐19: A systematic review of cases

Late peripheral facial paralysis after COVID-19: a rapid systematic review and two case reports

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