Peripheral Edema Related to Paroxetine Discontinuation: A Case Report

Mermi, Osman; Atmaca, Murad

doi:10.5455/bcp.20140805122657

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…9 The classic selective serotonin reuptake inhibitor (SSRI), paroxetine, will cause frigidity, edema of surrounding tissues, and extrapyramidal reactions. [10][11][12] Therefore, new therapeutic approaches await to be developed and further verified.…”

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confidence: 99%

Selenium-enrichedBifidobacterium longumDD98 relieves irritable bowel syndrome induced by chronic unpredictable mild stress in mice

Jin,

Hu,

Lin

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Selenium-enrichedBifidobacterium longumDD98 relieves irritable bowel syndrome induced by chronic unpredictable mild stress in mice

Jin,

Hu,

Lin

et al. 2023

Food Funct.

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Peripheral edema associated with antidepressant use: Systematic review of case reports

Joseph,

Vishwanath,

Praharaj

2023

Human Psychopharmacology

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BackgroundOedema associated with psychotropics can impose a considerable burden, leading to increased morbidity and cost. Peripheral oedema is sometimes related to the use of antidepressants, which are among the most prescribed psychotropic medications. We reviewed the reported cases of antidepressant‐associated oedema to understand the risk factors, aetiology and outcome.MethodsWe searched the Medline, Web of Science and Embase databases to identify reported cases of peripheral oedema associated with antidepressant use. We included studies published in English and those with full‐text availability. A systematic review of the reports was done to identify the antidepressants associated with oedema, explore possible risk factors, investigate potential mechanisms, and assess the outcome.ResultsWe identified a total of 45 cases (27 case reports and five case series) that reported oedema associated with antidepressant use. Almost all major classes of antidepressants were found to be associated with oedema. Among these drugs, trazodone, mirtazapine, and escitalopram were the most implicated. Older age and female gender were more commonly associated with oedema. Etiologically, antagonism of α1 adrenergic receptors and 5HT2A receptors, leading to vasodilation and oedema, emerged as the most prevalent mechanisms. In most cases, the oedema subsided following the discontinuation of the antidepressants.ConclusionsPeripheral oedema associated with antidepressant use can represent a significant adverse drug reaction involving various classes of antidepressants. To ensure timely identification and proper management of oedema, regular monitoring is crucial.

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Paroxetine withdrawal

2015

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Peripheral Edema Related to Paroxetine Discontinuation: A Case Report

Cited by 3 publications

References 11 publications

Selenium-enrichedBifidobacterium longumDD98 relieves irritable bowel syndrome induced by chronic unpredictable mild stress in mice

Selenium-enrichedBifidobacterium longumDD98 relieves irritable bowel syndrome induced by chronic unpredictable mild stress in mice

Peripheral edema associated with antidepressant use: Systematic review of case reports

Paroxetine withdrawal

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