Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: An exploratory study

Cisbani, Giulia; Koppel, Alex; Knezevic, Dunja; Suridjan, Ivonne; Mizrahi, Romina; Bazinet, Richard P.

doi:10.1016/j.bbi.2020.02.014

Cited by 21 publications

(11 citation statements)

References 77 publications

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“…Pro- and anti-inflammatory cytokines are both decisive for the Aβ plaques’ onset in the brains of AD patients. In the aging brain, a combination of cytokines, such as IL-1β, IL-6, IL-8, IL-10, IL-12 and TNFα, is reported to trigger inflammatory processes associated with cortical atrophy [ 67 ].…”

Section: Il-10 In Brain Diseasesmentioning

confidence: 99%

The Regulatory Role of IL-10 in Neurodegenerative Diseases

2020

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IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory modulator of glial activation, preventing inflammation-mediated neuronal degeneration under pathological conditions. In this narrative review, we summarize recent insights about the role of IL-10 in the neurodegeneration associated with neuroinflammation, in diseases such as Multiple Sclerosis, Traumatic Brain Injury, Amyotrophic lateral sclerosis, Alzheimer’s Disease, and Parkinson’s Disease, focusing on the contribution of this cytokine not only in terms of protective action, but also as possibly responsible for clinical worsening. The knowledge of this double face of the same coin, regarding the biological role of the IL-10, could aid the development of targeted therapies useful for limiting neurodegenerative processes.

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Section: Il-10 In Brain Diseasesmentioning

confidence: 99%

The Regulatory Role of IL-10 in Neurodegenerative Diseases

2020

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“…Bioassays have shown increased TSPO binding throughout the brain of AD patients compared to healthy controls, with similar but more modest effects observed in MCI patients [55]. Still, correlations between PET measures and cognition were not present in other studies of MCI patients [51,56]. These findings bring into question whether neuroinflammation is a primary or secondary event in dementia progression.…”

Section: Other Potential Biomarkersmentioning

confidence: 94%

A Workshop on Cognitive Aging and Impairment in the 9/11-Exposed Population

Daniels

Clouston

Hall

et al. 2021

IJERPH

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The terrorist attacks on 11 September 2001 potentially exposed more than 400,000 responders, workers, and residents to psychological and physical stressors, and numerous hazardous pollutants. In 2011, the World Trade Center Health Program (WTCHP) was mandated to monitor and treat persons with 9/11-related adverse health conditions and conduct research on physical and mental health conditions related to the attacks. Emerging evidence suggests that persons exposed to 9/11 may be at increased risk of developing mild cognitive impairment. To investigate further, the WTCHP convened a scientific workshop that examined the natural history of cognitive aging and impairment, biomarkers in the pathway of neurodegenerative diseases, the neuropathological changes associated with hazardous exposures, and the evidence of cognitive decline and impairment in the 9/11-exposed population. Invited participants included scientists actively involved in health-effects research of 9/11-exposed persons and other at-risk populations. Attendees shared relevant research results from their respective programs and discussed several options for enhancements to research and surveillance activities, including the development of a multi-institutional collaborative research network. The goal of this report is to outline the meeting’s agenda and provide an overview of the presentation materials and group discussion.

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“…Total lipids were extracted from serum sample following the protocol described by Cisbani et al (2020) and Metherel et al (2016) and modified from Folch et al (1957). Briefly, 100 μl of serum was extracted in a 2:1 chloroform:methanol:0.88% potassium chloride solution.…”

Section: Methodsmentioning

confidence: 99%

Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long‐term cannabis users: A secondary analysis of a case–control study

Cisbani

Koppel

Metherel

et al. 2022

Lipids

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Cannabis is now legal in many countries and while numerous studies have reported on its impact on cognition and appetite regulation, none have examined fatty acid metabolism in young cannabis users. We conducted an exploratory analysis to evaluate cannabis impact on fatty acid metabolism in cannabis users (n = 21) and non‐cannabis users (n = 16). Serum levels of some saturated and monounsaturated fatty acids, including palmitic, palmitoleic, and oleic acids were higher in cannabis users compared to nonusers. As palmitic acid can be derived from diet or lipogenesis from sugars, we evaluated lipogenesis using a de novo lipogenesis index (palmitate/linoleic acid) and carbon‐specific isotope analysis, which allows for the determination of fatty acid 13C signature. The significantly higher de novo lipogenesis index in the cannabis users group along with a more enriched 13C signature of palmitic acid suggested an increase in lipogenesis. In addition, while serum glucose concentration did not differ between groups, pyruvate and lactate were lower in the cannabis user group, with pyruvate negatively correlating with palmitic acid. Furthermore, the endocannabinoid 2‐arachidonoylglycerol was elevated in cannabis users and could contribute to lipogenesis by activating the cannabinoid receptor 1. Because palmitic acid has been suggested to increase inflammation, we measured peripheral cytokines and observed no changes in inflammatory cytokines. Finally, an anti‐inflammatory metabolite of palmitic acid, palmitoylethanolamide was elevated in cannabis users. Our results suggest that lipogenic activity is increased in cannabis users; however, future studies, including prospective studies that control dietary intake are required.

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Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: An exploratory study

Cited by 21 publications

References 77 publications

The Regulatory Role of IL-10 in Neurodegenerative Diseases

The Regulatory Role of IL-10 in Neurodegenerative Diseases

A Workshop on Cognitive Aging and Impairment in the 9/11-Exposed Population

Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long‐term cannabis users: A secondary analysis of a case–control study

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