Peripheral chemoreceptor control of ventilation following sustained hypoxia in young and older adult humans

Vovk, Andrea; Smith, W. D. F.; Paterson, Nicole D.; Cunningham, David A.; Paterson, Donald H.

doi:10.1113/expphysiol.2004.027532

Cited by 15 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the increase in the number of type II stem cells could contribute towards the maintenance of CB function (Hurst et al 1985;Porzionato et al 2005). The present work supports previous findings in humans-absence of alterations in the peripheral control of ventilatory responses to hypoxia (Pokorski et al 2004;Vovk et al 2004), providing evidence that structural and neurochemical changes caused by aging in the carotid body are further compensated. The finding that changes in cAMP content at the CB in response to O 2 concentrations did not change with aging, suggests that the compensatory mechanism could occur within the CB as a whole.…”

Section: Discussionsupporting

confidence: 81%

“…However, there is increasing evidence that several physiological functions are well preserved in aging. Namely, several studies have examined the age-related changes in the ventilatory response to hypoxia and found a maintained ventilatory response throughout aging, suggesting that no alteration in peripheral chemoreception occurred in old rats (Pokorski and Antosiewicz 2010) or humans (Smith et al 2001;Pokorski et al 2004;Vovk et al 2004). …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Carotid body function in aged rats: responses to hypoxia, ischemia, dopamine, and adenosine

Monteiro

Batuca

Obeso

et al. 2010

AGE

View full text Add to dashboard Cite

The carotid body (CB) is the main arterial chemoreceptor with a low threshold to hypoxia. CB activity is augmented by A 2 -adenosine receptors stimulation and attenuated by D 2 -dopamine receptors. The effect of aging on ventilatory responses mediated by the CB to hypoxia, ischemia, and to adenosine and dopamine administration is almost unknown. This study aims to investigate the ventilatory response to ischemia and to adenosine, dopamine, and their antagonists in old rats, as well as the effect of hypoxia on adenosine 3′,5′-cyclic monophosphate (cAMP) accumulation in the aged CB. In vivo experiments were performed on young and aged rats anesthetized with pentobarbitone and breathing spontaneously. CB ischemia was induced AGE (2011) 33:337-350 DOI 10.1007 Scientific knowledge on the subject The functional ventilatory consequences of the morphological and molecular changes in the carotid body observed in aged animals, as well as the ventilatory effects of dopamine and adenosine in old animals, are still unknown.What this study adds to the field The carotid body's peripheral control of ventilation is not impaired by aging. The preservation of the inhibitory and excitatory effects on ventilation caused by exogenous dopamine and adenosine, respectively, should be taken into account in the therapeutic use of these amines and their agonists and antagonists in elderly people. by bilateral common carotid occlusions. cAMP content was measured in CB incubated with different oxygen concentrations. Hyperoxia caused a decrease in cAMP in the CB at all ages, but no differences were found between normoxia and hypoxia or between young and old animals. The endogenous dopaminergic inhibitory tonus is slightly reduced. However, both the ventilation decrease caused by exogenous dopamine and the increase mediated by A 2A -adenosine receptors are not impaired in aged animals. The bradycardia induced by adenosine is attenuated in old rats. The CB's peripheral control of ventilation is preserved during aging. Concerns have also arisen regarding the clinical usage of adenosine to revert supraventricular tachycardia and the use of dopamine in critical care situations involving elderly people.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Carotid body function in aged rats: responses to hypoxia, ischemia, dopamine, and adenosine

Monteiro

Batuca

Obeso

et al. 2010

AGE

View full text Add to dashboard Cite

show abstract

“…Adapted from Lhuissier et al, 2012. Pokorski et al, 2004;Vovk et al, 2004;Paleczny et al, 2014) while some others found a reduced HVR in old persons (Kronenberg and Drage, 1973;Peterson et al, 1981;Serebrovskaya et al, 2000;Garcia-Rio et al, 2007). Chapman and Cherniack (1987) were the only authors to report an enhanced HVR in the elderly.…”

Section: Longitudinal Studymentioning

confidence: 94%

“…The influence of aging on ventilatory response to acute hypoxia has been scarcely studied in humans. The previous protocols compared young (20-40 years) to older (60-85 years) groups and always included a limited number of subjects, between 15 (Vovk et al, 2004) and112 (Garcia-Rio et al, 2007). Most of these studies used isocapnic hypoxia and all focused on response at rest.…”

Section: Longitudinal Studymentioning

confidence: 99%

Aging, Tolerance to High Altitude, and Cardiorespiratory Response to Hypoxia

Richalet

Lhuissier

2015

High Altitude Medicine & Biology

View full text Add to dashboard Cite

Richalet, Jean-Paul, and François J. Lhuissier. Aging, tolerance to high altitude, and cardiorespiratory response to hypoxia. High Alt Med Biol. 16:117-124, 2015.--It is generally accepted that aging is rather protective, at least at moderate altitude. Some anecdotal reports even mention successful ascent of peaks over 8000 m and even Everest by elderly people. However, very few studies have explored the influence of aging on tolerance to high altitude and prevalence of acute high altitude related diseases, taking into account all confounding factors such as speed of ascent, altitude reached, sex, training status, and chemo-responsiveness. Changes in physiological responses to hypoxia with aging were assessed through a cross-sectional 20-year study including 4675 subjects (2789 men, 1886 women; 14-85 yrs old) and a longitudinal study including 30 subjects explored at a mean 10.4-year interval. In men, ventilatory response to hypoxia increased, while desaturation was less pronounced with aging. Cardiac response to hypoxia was blunted with aging in both genders. Similar results were found in the longitudinal study, with a decrease in cardiac and an increase in ventilatory response to hypoxia with aging. These adaptive responses were less pronounced or absent in post-menopausal untrained women. In conclusion, in normal healthy and active subjects, aging has no deleterious effect on cardiac and ventilatory responses to hypoxia, at least up to the eighth decade. Aging is not a contraindication for high altitude, as far as no pathological condition interferes and physical fitness is compatible with the intensity of the expected physical demand of one's individual. Physiological evaluation through hypoxic exercise testing before going to high altitude is helpful to detect risk factors of severe high altitude-related diseases.

show abstract

“…The HVR is not maintained post hypoxic exposure. It is followed by the hypoxic ventilatory decline (HVD), whereby minute ventilation declines and the partial pressure of carbon dioxide is allowed to rise [7,8]. This occurs for a short period of less than one hour and then ventilation continues to increase again.…”

Section: Ventilationmentioning

confidence: 99%

Respiratory Physiology at Altitude

Sandberg

Naylor

2011

J R Army Med Corps

View full text Add to dashboard Cite

The changes in respiratory physiology that occur with increasing altitude are driven by the fall in the partial pressure of oxygen that occurs with decreasing barometric pressure. At altitude, respiratory system changes occur which impact on each step of the oxygen cascade that occurs within the body. These changes are pivotal to the process of acclimatisation to altitude. The study of human respiratory physiology at altitude has the potential to produce research that will be translational to disease states characterised by hypoxaemia.

show abstract

Peripheral chemoreceptor control of ventilation following sustained hypoxia in young and older adult humans

Cited by 15 publications

References 31 publications

Carotid body function in aged rats: responses to hypoxia, ischemia, dopamine, and adenosine

Carotid body function in aged rats: responses to hypoxia, ischemia, dopamine, and adenosine

Aging, Tolerance to High Altitude, and Cardiorespiratory Response to Hypoxia

Respiratory Physiology at Altitude

Contact Info

Product

Resources

About