J. Neurosci. Res. volume 87, issue 6, P1381-1388 2009 DOI: 10.1002/jnr.21958 View full text
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Gregory W. Konat, Elizabeth Borysiewicz, Daniel Fil, Isaac James

Abstract: It is well established that mediators of peripheral inflammation are relayed to the brain and elicit sickness behavior via neuroinflammatory agents that target neuronal substrates. In the present study, we used double-stranded RNA (dsRNA), a viral replication intermediate, to mimic the acute phase of viral infection. C57BL/6 mice were injected intraperitoneally with 12 mg/kg of synthetic dsRNA, i.e., polyinosinic-polycytidylic acid (PIC). The treatment induced severe sickness behavior in the animals as reveale…

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