Peripheral calcifying odontogenic cyst with multinucleated giant cell formation

Hsu, Han-Jen; Chen, Yuk-Kwan; Wang, Wen-Chen; Tseng, Chiu‐yu

doi:10.1016/j.jds.2019.01.003

Cited by 2 publications

(2 citation statements)

References 4 publications

(8 reference statements)

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“…On the other hand, despite the foreign body reaction being a common feature reported in the intraosseous/central variant of COC, it is an uncommon finding in the E/PCOC [5]. Although it seems a trivial phenomenon, in our case, it represented a challenge, due to the central area of the major element being occupied by this inflammatory reaction, simulating a solid lesion perception; thus, distinction between E/PCOC vs. extraosseous/peripheral dentinogenic ghost cell tumor (E/PDGCT) was only achieved through immunohistochemistry, which allowed us to resolve the topographic expression of cytokeratins in a cystic epithelium conformation.…”

Section: Discussionmentioning

confidence: 92%

“…Calcifying odontogenic cyst (COC) represents ≤1% of all odontogenic cysts, and its extraosseous/peripheral variant (E/PCOC) represents 3-10%, in contrast to the intraosseous/central variant of COC (90-97%), making E/PCOC an unusual lesion [1,2]. In this sense, to our knowledge, 41 cases of E/PCOC have been reported to date [2][3][4][5][6]. COC was considered as a tumor in the 2005 WHO classification; however, in the later (2017) [7], it was redefined as a simple cyst with ameloblastoma-like epithelium, and in the latest (2022), WHO classification is defined as a "developmental odontogenic cyst characterized histologically by ghost cells, which often calcify" [1], removing the ameloblastic features of epithelium.…”

Section: Introductionmentioning

confidence: 99%

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Extraosseous Calcifying Odontogenic Cyst Initially Interpreted as a Parulis

Santana-Arenas,

Guardado-Luevanos,

Padilla-Rosas

et al. 2024

Case Reports in Dentistry

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Extraosseous variants of odontogenic cysts are an infrequent clinical finding, although they have a relatively indolent biological behavior compared to their intraosseous counterparts; due to their nature and clinical appearance, these lesions can be confused with multiple entities that affect soft tissues, so their diagnosis can only be achieved through surgical removal and subsequent histopathological analysis. The extraosseous/peripheral variant of calcifying odontogenic cyst (E/PCOC) has a heterogeneous clinical presentation mainly in terms of size and involvement or not of adjacent anatomical structures such as bone and teeth; in addition, there are few cases reported to date; thus, there are still clinical features to be elucidated. This report presents a child affected by E/PCOC in an unusual location, as well as its therapeutic management, which at first time was suspected of endodontic nature, due to a history of dental trauma.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Extraosseous Calcifying Odontogenic Cyst Initially Interpreted as a Parulis

Santana-Arenas,

Guardado-Luevanos,

Padilla-Rosas

et al. 2024

Case Reports in Dentistry

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Peripheral calcifying odontogenic cyst: a case report and comprehensive review of 60 years of literature

Sheng

Tipton

Chang

et al. 2023

Front. Oral. Health

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Peripheral Calcifying Odontogenic Cyst (PCOC) is the extraosseous form of calcifying odontogenic cyst that is limited to peripheral soft tissue without bony involvement. This case report presents a case of PCOC manifested as a progressive growth of gingival mass in a young male treated with excisional biopsy. Histological examination confirmed diagnosis of PCOC with presence of characteristic ghost cells and sporadic calcifications. No recurrence of the lesion and no complication were noted at three-year follow-up. Review of available literature on PCOC noted a predilection of occurrence in the mandible (61%) and in the anterior area of the jaws (58%). Mean age of patients was 41.7 ± SD25.43 (7–83) and 95% CI [33.6, 49.8] yrs. Mean size of the lesions was 1.38 ± SD1.1 (0.5–4.3) and 95% CI [0.93, 1.83] cm. Gender distribution was noted to be 51.3% male and 48.7% female.

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Peripheral calcifying odontogenic cyst with multinucleated giant cell formation

Cited by 2 publications

References 4 publications

Extraosseous Calcifying Odontogenic Cyst Initially Interpreted as a Parulis

Extraosseous Calcifying Odontogenic Cyst Initially Interpreted as a Parulis

Peripheral calcifying odontogenic cyst: a case report and comprehensive review of 60 years of literature

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