Peripheral blood stem cell transplantation

Craig, J. I. O.; Turner, M.; Parker, A. C.

doi:10.1016/0268-960x(92)90008-e

Cited by 29 publications

(10 citation statements)

References 86 publications

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“…Total registration of all new cases of CGL has been in place since January 1988. A median of 25 new cases present per annum (range [16][17][18][19][20][21][22][23][24][25][26][27][28][29]. 4 From January 1994 a programme of early intervention for patients under 60 years of age was begun with the cooperation of all 25 regional haematologists.…”

Section: Patients and Mobilization Therapymentioning

confidence: 99%

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Collection of Philadelphia-negative peripheral blood progenitor cells in unselected patients with chronic granulocytic leukaemia

et al. 1998

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Thirty unselected patients with chronic granulocytic leukaemia (CGL), age range 22-59 years, were treated with intensive chemotherapy and G-CSF to mobilize peripheral blood progenitor cells (PBPC). Chemotherapy was well tolerated and PBPC were collected by leukapheresis early during white cell recovery. PBPC collections considered adequate for engraftment were collected in 21 patients. Cytogenetic analysis of all collections in these patients showed Ͼ75% Ph negativity (range 79-100%) in 10. Successful collections, ie those Ͼ75% Ph negative and with total cell count of Ͼ1 × 10 6 CD34+ve cells/kg or Ͼ20 × 10 4 CFU-GM/kg were further analysed by Southern blot or RT-PCR. All samples were positive for the bcr/abl transcript. Patients with a low Sokal score (Ͻ0.8) were more likely to achieve a successful collection. In contrast, there was no association between transcript expression and likelihood of successful collection. We have confirmed that it is possible to mobilize and collect Ph-negative enriched PBPC in unselected patients with CGL. This procedure is more likely to be successful earlier rather than later in the course of the disease. Whether such collections will give an advantage over unmanipulated autologous bone marrow transplantation in CGL requires further study, but our experience suggests that suitable material for autologous rescue can be obtained from approximately one third of eligible, unselected young patients.

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Section: Patients and Mobilization Therapymentioning

confidence: 99%

“…20 The minimum criteria for adequate engraftment are considered to be Ͼ20 × 10 4 /kg CFU-GM and Ͼ1 × 10 6 /kg CD34 + cells. 21 Malignant cell contamination was assessed by both standard cytogenetic analysis and molecular techniques. For cytogenetics a target of 30 metaphases was required for accurate results.…”

Section: Leukapheresismentioning

confidence: 99%

Collection of Philadelphia-negative peripheral blood progenitor cells in unselected patients with chronic granulocytic leukaemia

et al. 1998

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“…Peripheral blood stem cell (PBSC) harvest by apheresis, both autologous and allogeneic, is an increasingly important procedure utilized in the treatment of many malignancies [1][2][3]. While peripheral venous access can be used for these procedures, large bore central venous catheters (CVCs) consistently provide higher flow rates and therefore shorten apheresis time [4].…”

Section: Introductionmentioning

confidence: 99%

Image-guided central venous catheter placement for apheresis in allogeneic stem cell donors

et al. 2000

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“…This allowed for the use of mobilized precursors from peripheral blood as an additional or alternative source of HSC for transplantation. At present, the number of autotransplantations of peripheral blood ceils surpassed that of transplantation of autologous bone marrow [3]. Since cytokines are less dangerous than chemotherapy, practical studies on eytokine-induced Hematology Research Center, Russian Academy of Medical Sciences, Moscow mobilization of HSC in healthy donors as a source of peripheral blood precursor cells are recommended and have been initiated [6].…”

mentioning

confidence: 99%

Effect of cytokines (G-CSF and SCF) on stromal precursor cells

Drize

Chertkov

1998

Bull Exp Biol Med

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Repeated injections of hemopoietic cytokines (granulocyte colony-stimulating factor and stem-cell factor) to normal mice increase the content of bone marrow stromal precursors, which are capable of transferring hemopoietic microenvironment; cytokines have no effect on osteogenic potencies of stromal precursors. In contrast, injection of granulocyte colonystimulating factor during organization of a hemopoietic microenvironment considerably decreases the number of stromal precursors in the ectopic focus. The role of these stromal effects of cytokines in cytokine-induced mobilization of stem cells from the bone marrow into circulation remains unclear.

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Peripheral blood stem cell transplantation

Cited by 29 publications

References 86 publications

Collection of Philadelphia-negative peripheral blood progenitor cells in unselected patients with chronic granulocytic leukaemia

Collection of Philadelphia-negative peripheral blood progenitor cells in unselected patients with chronic granulocytic leukaemia

Image-guided central venous catheter placement for apheresis in allogeneic stem cell donors

Effect of cytokines (G-CSF and SCF) on stromal precursor cells

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