Peripheral blood mononuclear cell adenosine deaminase activity in renal allograft recipients

Lum, Caliann T.; Sutherland, David E.R.; Yasmineh, Walid G.; Najarían, John S.

doi:10.1016/0022-4804(78)90032-x

Cited by 16 publications

(6 citation statements)

References 8 publications

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“…Second, adenosine is deaminated rapidly into inosine by adenosine deaminase (ADA). ADA is found in large amounts particularly in mononuclear cells [30,31], where it plays a major role in adenosine concentration regulation in both extracellular and intracellular spaces [32,33]. Some researchers had suggested that it was mediated by a decrease in the activity and expression of ADA, increased production of adenosine, and an induced imbalance in adenosine receptors.…”

Section: Case-control Studymentioning

confidence: 98%

“…When xanthine oxidase converts hypoxanthine to xanthine in the presence of molecular oxygen, superoxide radicals (O 2 •− ) are released. Reactive oxygen species (ROS) generated during the progression of DN play a major role in microvascular dysfunction and exert direct tissue damage, leading to lipid peroxidation, denaturation of proteins, and oxidation of DNA [30]. Many direct evidences have demonstrated that ROS was one of the most important mechanisms of DN.…”

Section: Case-control Studymentioning

confidence: 99%

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Ultraviolet and tandem mass spectrometry for simultaneous quantification of 21 pivotal metabolites in plasma from patients with diabetic nephropathy

Xia

Liang

et al. 2009

Journal of Chromatography B

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Section: Case-control Studymentioning

confidence: 98%

Section: Case-control Studymentioning

confidence: 99%

Ultraviolet and tandem mass spectrometry for simultaneous quantification of 21 pivotal metabolites in plasma from patients with diabetic nephropathy

Xia

Liang

et al. 2009

Journal of Chromatography B

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“…Hovi et al have shown that adenosine deaminase activity is vital for lymphocyte proliferation [22]. Lum et al noted increasing levels of adenosine deaminase activity correlated with enhanced immune function in renal transplant patients who were in the process of rejecting their allografts [23]. It has also been shown that addition of adenosine deaminase inhibitors impaired lymphocyte mediated cytotoxicity against tumor cells [24].…”

Section: Discussionmentioning

confidence: 99%

“…Lum tumor injection, indicates the critical nature of the time et al noted increasing levels of adenosine deaminase sequence of the host exposure to elevated levels of PGE activity correlated with enhanced immune function in in relation to tumor challenge. This also emphasizes the renal transplant patients who were in the process of complex questions which need to be answered prior to rejecting their allografts [23]. It has also been shown that initiating clinical trials of PGE analogs or inhibitors in addition of adenosine deaminase inhibitors impaired surgical oncology patients.…”

Section: The Second Model (Peritoneal Carcinomatosis Model) Materialsmentioning

confidence: 99%

Effect of prostaglandin E in multiple experimental models. VIII. effect on host response to metastatic tumor

Waymack

Flescher

Venkatraman

et al. 1991

Journal of Surgical Oncology

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Prostaglandin E (PGE) is produced by certain tumors and is reported to decrease primary tumor growth. We evaluated its effect in multiple tumor models utilizing a I week course of the long acting PGE derivative dimethyl-PGE (dPGE) at a dosage of 100 Jg/kg/day vs. a lactated Ringers control. For all tumor models, a suspension of I X 106 colon carcinoma cells were injected into Wistar-Furth rats. When the suspension was injected subcutaneously and the drug was begun at the time of tumor challenge, there was no effect on survival. When the tumor was injected intraperitoneally or intravenously and the drug begun at the time of tumor challenge, dPGE decreased survival time. When the tumor was administered intravenously but dPGE was delayed for 5 days, there was no effect 1 on survival time. When rats were given a I week course of dPGE or saline, dPGE was found not to alter natural killer (NK) cell cytotoxicity, macrophage cytotoxicity, spontaneous lymphocyte blastogenesis, or mitogen stimulated blastogenesis. dPGE failed to alter lymphocyte metabolism of glucost. ;-nonstimulated lymphocytes, but decreased the rate of INTRODUCTIONThis belief is based primarily on in vitro studies where Oncology patients have been demonstrated to have leukocytes were cultured in the presence of PGE and elevated levels of prostaglandin E (PGE) in their primary were then assayed for various immune functions. These tumor tissue and systemic circulation Il]. The PGE has studies demonstrated that, in in vitro models, PGE also been reported to exert autocrine, paracrine, and impairs lymphocyte blastogenesis, natural killer (NK) endocrine effects on both the tumor, and the host cell cytotoxicity, macrophage cytotoxicity, and granuloresponse to the tumor [2]. The majority of effects of PGE cyte chemotaxis [5][6][7]. There have, however, been very on tumor cells appear to be directed towards inducing few studies evaluating the effect of PGE on immune differentiation of the tumor cell and to decreasing the rate

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“…Increased ADA activity was found in typhoid fever and brucellosis (Galanti et al, 1981), in patients rejecting transplanted kidneys (Lum et al, 1978), in acute leukaemia (Smyth & Harrap, 1975) and in some patients with lymphoma (Meier et al, 1976). In contrast, low ADA levels were reported in chronic lymphocytic leukaemia (Tung et al, 1976) and in liver cirrhosis (Galanti et al, 1978 Boyum (1968).…”

mentioning

confidence: 99%

Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours

Russo¹,

Giancane²,

Apice³

et al. 1981

Br J Cancer

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Summary.-Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) levels of peripheral blood mononuclear cells were measured in 34 patients with various types of solid tumours. The mean ADA activity was found to be significantly lower than in controls (P < 0.005). Patients with nonresectable tumour or with recurrence after radical surgery showed low ADA levels, while patients operated upon and without recurrence had enzymatic activity not different from that of normal controls. The mean value of PNP activity was similar to that of normal controls; no differences were observed between operated patients without recurrence and cases with nonresectable tumour or with recurrence after surgical treatment. No effects on ADA and PNP levels appeared to be induced by chemotherapy.

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Peripheral blood mononuclear cell adenosine deaminase activity in renal allograft recipients

Cited by 16 publications

References 8 publications

Ultraviolet and tandem mass spectrometry for simultaneous quantification of 21 pivotal metabolites in plasma from patients with diabetic nephropathy

Ultraviolet and tandem mass spectrometry for simultaneous quantification of 21 pivotal metabolites in plasma from patients with diabetic nephropathy

Effect of prostaglandin E in multiple experimental models. VIII. effect on host response to metastatic tumor

Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours

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