Peripheral blood lymphocyte subsets in patients with stomach cancer

Hong, Weon Seon; Min, Young Il; Son, Young-Jun; Hong, Seok Il

doi:10.3346/jkms.1995.10.3.164

Cited by 20 publications

(15 citation statements)

References 3 publications

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“…Several studies have reported on depressed CD8+ cells in advanced stages of stomach [6], lung [7] and ovarian cancer [8]. Only limited data exist on NKT cells in prostatic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Natural Killer T Cells in Patients with Prostatic Carcinoma

Schwemmer¹

2003

Urol Int

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Recent interest has focused on natural killer T (NKT) cells as effector cells in a possible new form of immunotherapy. NKT cells express T cell and natural killer cell receptors. They are CD1d-dependent and can be stimulated by α-galactosylceramide. We have studied peripheral blood levels of NKT cells simultaneously with CD8+ cells and natural killer cells in 54 patients with prostatic carcinoma. Levels of NKT cells in patients with androgen withdrawal and stable PSA levels were 211.8 ± 138.4 cells/µl and in patients with rising PSA levels were 27.0 ± 22.1 cells/µl. A similar but less pronounced difference in CD8+ cells between these groups was found (656.4 vs. 212.0 cells/µl). Comparing all 54 patients studied, a positive correlation was found between the levels of NKT cells and CD8+ cells (r = 0.83). Our results suggest an important and regulatory role of NKT cells in patients with prostatic carcinoma.

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“…Several studies have reported on depressed CD8+ cells in advanced stages of stomach [6], lung [7] and ovarian cancer [8]. Only limited data exist on NKT cells in prostatic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Natural Killer T Cells in Patients with Prostatic Carcinoma

Schwemmer¹

2003

Urol Int

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“…Previous reports, however, have found an association between lymphopenia and neoplasia progression. 32,33 Lymphatic involvement is one of the most important prognostic factors in gastric cancer. 12,34 The prognostic value of LR in the evaluation of lymph node status found in this study confirms the results from previous studies.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Score in Gastric Cancer: The Importance of a Conjoint Analysis of Clinical, Pathologic, and Therapeutic Factors

et al. 2006

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Background: This study was designed to establish a prognostic score for gastric cancer that takes into account factors related to the tumor, the patient, and the treatment.Methods: Two hundred thirty patients with gastric adenocarcinoma admitted to the Department of Abdominal Surgery at Hospital do Caˆncer A. C. Camargo (Sa˜o Paulo) and treated by gastrectomy from January 1992 until December 1996 were included in this retrospective cohort. The prognostic score was created according to the variables identified in the multivariate analysis and by using the regression coefficients generated by the Cox regression.Results: The 5-year overall survival rate was 44.5%. The final multivariate model identified six variables with a significant and independent effect on survival: sex, weight loss, lymphocyte count, tumor-node-metastasis staging, lymphadenectomy, and lymph node ratio. Patients were divided into four groups according to their scores, as follows: group 1, 0 to 3.0; group 2, 3.5 to 5.5; group 3, 6.0 to 8.5; and group 4, 9.0 to 14.0. The 5-year survival rates were 91.5%, 49.3%, 20.3%, and .0% for the score groups 1, 2, 3, and 4, respectively (P < .001). The score was superior in the assessment of prognosis when compared with tumor-node-metastasis staging alone.Conclusions: It is possible to create a prognostic score that simultaneously includes factors related to the tumor, patient, and treatment, thus generating a more effective system in predicting the prognosis than the morphology-based staging systems.

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“…Altered immune response to gastric cancer has been previously reported [12,13]. Both NLR and thrombocytosis have seperately investigated as a prognostic factors in gastric cancer [7,9,14].…”

Section: Introductionmentioning

confidence: 96%

The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment

et al. 2009

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We aimed to investigate the prognostic significance of neutrophil, lymphocyte, platelet, mean platelet value (MPV), platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) in patients with locally advanced gastric cancer (LAGC). One hundred sixty-eight patients with LAGC who had been followed-up between 2004 and 2008 were included in present study. The results of hematological (platelet, lymphocyte, neutrophil and MPV) and biochemical (uric acid and LDH) parameters were evaluated before treatment. NLR was divided into two groups as <2.56 and ≥2.57 and PLR was also divided into two groups as ≤160 and >160. Platelet counts and lymphocyte counts were also divided into two groups; ≤300.000/mm3 and >300.000/mm3, and <1,500/mm3 and ≥1,500/mm3, respectively. Results were evaluated with Kaplan-Meier and Long-rank tests. The mean age of patients at diagnosis was 60.1±12.1 and 114 of patients (67.8%) were male. For 168 patients, 48 months overall survival (OS) rate was 45.2% and the median OS was 39 months (range 33-44). In patients whose PLR was less than 160 (n=54), the median OS was 45 months (range 38-52) and also for cases whose PRL was greater than 160 (n=114), the median OS was 27 months (range 22-32) (p=0.006). While for fifty patients whose lymphocyte counts were less than 1,500, the median OS was 27 months (range 21-33), in cases with high lymphocyte counts (≥1,500) (n=118), it was 41 months (range 35-48) (p=0.03). The median OS was 41 (range 34-48) and 30 (range 23-37) months in two platelets groups, respectively (p=0.24). However, in the patients whose NLR was less than 2.56 (n=107), median OS was better than with cases whose NLR was greater than or equal to 2.56 (42 vs. 27 months). Routine peripheral blood counts may be useful prognostic factor for evaluating the accuracy of risk stratification in patients with radically resected gastric cancer Our results need to be confirmed by study including larger sample size in future.

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Peripheral blood lymphocyte subsets in patients with stomach cancer

Cited by 20 publications

References 3 publications

Natural Killer T Cells in Patients with Prostatic Carcinoma

Natural Killer T Cells in Patients with Prostatic Carcinoma

Prognostic Score in Gastric Cancer: The Importance of a Conjoint Analysis of Clinical, Pathologic, and Therapeutic Factors

The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment

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