Peripheral blood inflammatory markers in patients with attention deficit/hyperactivity disorder (ADHD): A systematic review and meta-analysis

Misiak, Błażej; Wójta-Kempa, Monika; Samochowiec, Jerzy; Schiweck, Carmen; Aichholzer, Mareike; Reif, Andreas; Samochowiec, Agnieszka; Stańczykiewicz, Bartłomiej

doi:10.1016/j.pnpbp.2022.110581

Cited by 27 publications

(48 citation statements)

References 54 publications

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“…Since BDNF is linked to neuronal survival, plasticity, and neurotransmitter modulation, there is a wealth of research supporting this association (Panja and Bramham, 2014). BDNF levels in the blood and brain are frequently lower in patients with mental and neurodegenerative illnesses (Misiak et al, 2022) Our ndings suggest that stilbene glucoside reduced the basic symptoms of ADHD by acting as BDNF and anti-in ammatory agent. This experiment has initially explored the neuro-in ammatory mechanism of ADHD, but the neuro-in ammatory mechanism is very complex and involves many cell types and signal pathways.…”

Section: Discussionmentioning

confidence: 79%

Stilbene Glucoside Ameliorates Symptoms of Attention Deficit Hyperactivity Disorder by Regulating BDNF Signal Pathway and Inhibiting Neuro-inflammation in Spontaneous Hypertensive Rats

Sun

Zhang

et al. 2022

Preprint

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Background We investigated the effect of Stilbene on inflammation and the underlying mechanisms in spontaneously hypertensive rats (SHRs). Methods Rats were divided into the control group, the model group, the positive group (4.56 mg/kg/day), Stilbene LD group (40 mg/kg), Stilbene MD group (60 mg/kg), and Stilbene HD group (80 mg/kg). The open field test (OFT) and Morris water maze test (MWM) were used to compare the behavior of the rats among the groups, while real-time polymerase chain reaction (PCR) and western blot were used to compare the expression of cytokines in different brain tissues among the groups. Results OFT and MWM revealed that stilbene significantly reduced hyperactivity and impulsivity, and improved spatial memory in spontaneously hypertensive rats. Stilbene reduced DHA levels in striatum and hippocampus, but increased the mRNA expressions of AKT1, BDNF, SOS1, PIK3CG, GAB1, and NTRK2, and the protein levels of SOS1, GAB1, AKT1, TrkB, and Kinase P110 beta in prefrontal, striatum, and hippocampus. Conclusions Stilbene reduced neuroinflammation and attenuated symptoms of ADHD in SHRs.

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Section: Discussionmentioning

confidence: 79%

Stilbene Glucoside Ameliorates Symptoms of Attention Deficit Hyperactivity Disorder by Regulating BDNF Signal Pathway and Inhibiting Neuro-inflammation in Spontaneous Hypertensive Rats

Sun

Zhang

et al. 2022

Preprint

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“…The heterogeneity of subjective research in systematic review might be one reason for the diluted result. A systematic review conducted by Misiak et al [86] has also found that lower TNF-α is meaningful in both adult and youth ADHD patients.…”

Section: Categorymentioning

confidence: 97%

“…Misiak et al [86] have conducted a systematic review on possible peripheral blood inflammatory markers in ADHD patients and found no association with IL-6 or IL-10 in ADHD. However, individual case-control studies conducted by Donfrancisco et al [98] have found that IL-6 and IL-10 levels are elevated in children with ADHD.…”

Section: Categorymentioning

confidence: 99%

Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder

Park¹

2022

Preprint

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Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder that can diminish the quality of life of both children and adults in academic, occupational, and social contexts. The kynurenine pathway (KP) contains a set of enzymatic reactions involved in tryptophan (TRP) degradation. It is known to be associated with the risk of developing ADHD. This review will address the KP and underlying mechanism of inflammation in ADHD. Potential inflammatory biomarkers reported in the most recent studies are summarized. Although a strong neuroimmunological basis has been established due to advances of recent neurobiological research, the pathophysiology of ADHD remains unclear.

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“…Individual relationships of these markers with various mental disorders in perinatal and offspring outcomes, chronic states, and pre/post-treatment have been examined based on cytokines, C-reactive protein, hormones, neurotrophins, and so on. Some commonly investigated cytokine measures are summarized in Table 1 [ 12 , 40 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ]. When interpreting reports of individual studies, it is crucial to consider the extent to which other factors affecting peripheral cytokines are accounted for in specific analyses.…”

Section: Potential Inflammatory Biomarkers In Adhdmentioning

confidence: 99%

“…Misiak et al [ 86 ] conducted a systematic review on possible peripheral blood inflammatory markers in ADHD patients and found no association with IL-6 or IL-10 in ADHD. However, individual case-control studies conducted by Donfrancisco et al [ 98 ] have found that IL-6 and IL-10 levels are elevated in children with ADHD.…”

Section: Potential Inflammatory Biomarkers In Adhdmentioning

confidence: 99%

Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder

Park

2022

IJMS

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder that can diminish the quality of life of both children and adults in academic, occupational, and social contexts. The kynurenine pathway (KP) contains a set of enzymatic reactions involved in tryptophan (TRP) degradation. It is known to be associated with the risk of developing ADHD. This review will address the KP and underlying mechanism of inflammation in ADHD. Potential inflammatory biomarkers reported in the most recent studies are summarized. Although a strong neuroimmunological basis has been established due to the advances of recent neurobiological research, the pathophysiology of ADHD remains unclear.

show abstract

Peripheral blood inflammatory markers in patients with attention deficit/hyperactivity disorder (ADHD): A systematic review and meta-analysis

Cited by 27 publications

References 54 publications

Stilbene Glucoside Ameliorates Symptoms of Attention Deficit Hyperactivity Disorder by Regulating BDNF Signal Pathway and Inhibiting Neuro-inflammation in Spontaneous Hypertensive Rats

Stilbene Glucoside Ameliorates Symptoms of Attention Deficit Hyperactivity Disorder by Regulating BDNF Signal Pathway and Inhibiting Neuro-inflammation in Spontaneous Hypertensive Rats

Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder

Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder

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