Peripheral blood circular RNA hsa_circ_0058493 as a potential novel biomarker for silicosis and idiopathic pulmonary fibrosis

Cheng, Zhounan; Wu, Shuangshuang; Zhao, Rui; Yu, Yuhui; Zhou, Yan; Zhou, Zhen; Yang, Dong; Qiu, Anni; Xu, Huiwen; Liu, Yiran; Zhang, Wendi; Tian, Tian; Wu, Qiuyun; Gu, Haiwei; Chu, Minjie

doi:10.1016/j.ecoenv.2022.113451

Cited by 25 publications

(12 citation statements)

References 46 publications

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“…Cheng et al observed that has_circ_0058493 was highly expressed in silicosis patients through RNA-sequencing. In particular, this study also found that hsa_circ_0058493 knockdown inhibited the expression of fibrotic molecules by influencing the EMT process [ 97 ] (Table 3 ).…”

Section: Ncrnamentioning

confidence: 80%

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The emerging role of epigenetic regulation in the progression of silicosis

Yin

Xie

et al. 2022

Clin Epigenet

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Silicosis is one of the most severe occupational diseases worldwide and is characterized by silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are still lacking at present. Therefore, elucidating the pathogenesis of silicosis plays a significant guiding role for its treatment and prevention. The occurrence and development of silicosis are accompanied by many regulatory mechanisms, including epigenetic regulation. The main epigenetic regulatory mechanisms of silicosis include DNA methylation, non-coding RNA (ncRNA), and histone modifications. In recent years, the expression and regulation of genes related to silicosis have been explored at epigenetic level to reveal its pathogenesis further, and the identification of aberrant epigenetic markers provides new biomarkers for prediction and diagnosis of silicosis. Here, we summarize the studies on the role of epigenetic changes in the pathogenesis of silicosis to give some clues for finding specific therapeutic targets for silicosis.

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Section: Ncrnamentioning

confidence: 80%

“…In particular, this study also found that hsa_circ_0058493 knockdown inhibited the expression of fibrotic molecules by influencing the EMT process [ 97 ] (Table 3 ).…”

Section: Ncrnamentioning

confidence: 80%

The emerging role of epigenetic regulation in the progression of silicosis

Yin

Xie

et al. 2022

Clin Epigenet

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“…Moreover, apart from circRNAs' biological functions in IPF, a recent study also suggested that peripheral blood circRNAs could act as potential biomarkers for IPF and silicosis. Using RNA-sequencing technique, Cheng et al reported that hsa_circ_0058493 was significantly upregulated in both silicosis and IPF peripheral blood samples [69]. Although this study revealed a potential circRNA as a biomarker, the sample size used in this study was too…”

Section: Idiopathic Pulmonary Fibrosismentioning

confidence: 81%

“…Promotes fibroblast proliferation and lung fibroblast-to-myofibroblast transition [68] hsa_circ_0058493 upregulated Potential biomarker candiate [69] Silicosis circZC3H4 upregulated Regulates fibroblast activation and proliferation [71] Cigarette particle-induced lung injury circFOXO3 upregulated Promotes inflammatory response [74] circRNA_0006892 downregulated Promotes cell apoptosis and inflammatory response [75] Pulmonary hypertension circRNA_004592 upregulated Promotes cell proliferation and inhibits cell apoptosis [79] Acute lung injury hsa_circ_0059930 upregulated Inhibits cell apoptosis and inhibits cell proliferation [81] circRNA_0001679 upregulated Promotes cell apoptosis and proinflammatory cytokines [82] circHECTD1 downregulated Inhibits cell apoptosis [83] Kidney Mesangial cell Injury circLRP6 upregulated Promotes inflammatory response [33] Acute kidney injury circ_0114428 upregulated Promotes inflammatory response [90] circFANCA upregulated Promotes cell apoptosis, inflammatory response, oxidative stress [91] circ_RASGEF1B upregulated Promotes cell apoptosis and inflammatory response [92] circ_BNIP3L upregulated Promotes inflammatory response and oxidative stress [93] circ_0114427 upregulated Promotes inflammatory response [94] circSnrk upregulated Promotes cell apoptosis [27] hsa_circ_010157 upregulated Promotes cell apoptosis and inflammatory response [95] circTLK1 upregulated Promotes cell apoptosis, inflammatory response, oxidative stress [96] circHIPK3 upregulated Promotes cell apoptosis and inflammatory response from circRNAs derived from the extracellular exosomes of TBI-induced mouse brain. The study suggested that the extracellular circRNAs in brain-derived exosomes could involve in dendrite development and glutamatergic synapse formation [48].…”

Section: Lung Idiopathic Pulomnary Fibrosis Circhipk3 Upregulatedmentioning

confidence: 99%

Circular RNAs in organ injury: recent development

et al. 2022

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Circular ribonucleic acids (circRNAs) are a class of long non-coding RNA that were once regarded as non-functional transcription byproducts. However, recent studies suggested that circRNAs may exhibit important regulatory roles in many critical biological pathways and disease pathologies. These studies have identified significantly differential expression profiles of circRNAs upon changes in physiological and pathological conditions of eukaryotic cells. Importantly, a substantial number of studies have suggested that circRNAs may play critical roles in organ injuries. This review aims to provide a summary of recent studies on circRNAs in organ injuries with respect to (1) changes in circRNAs expression patterns, (2) main mechanism axi(e)s, (3) therapeutic implications and (4) future study prospective. With the increasing attention to this research area and the advancement in high-throughput nucleic acid sequencing techniques, our knowledge of circRNAs may bring fruitful outcomes from basic and clinical research.

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“…Cerebellar degeneration‐related protein 1 antisense RNA (CDR1as), also known as circular RNA sponge for miR-7 (ciRS-7), was reported to antagonize miR-7 availability ( 25 ). By targeting different miRNAs and mRNAs, circRNAs are involved in the pathogenesis of a variety of diseases, including neurological diseases ( 26 ), psychiatric diseases ( 27 ), autoimmune diseases ( 28 ), cardiovascular diseases ( 29 , 30 ), cartilage degenerative diseases ( 31 , 32 ), diabetes ( 33 , 34 ), pulmonary fibrosis ( 35 , 36 ), and various cancers ( 10 , 37 – 39 ).…”

Section: Circrnasmentioning

confidence: 99%

CircRNAs: Roles in regulating head and neck squamous cell carcinoma

et al. 2022

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Head and neck squamous cell carcinoma (HNSCC), the most common head and neck malignant tumor, with only monotherapy, is characterized by poor prognosis, and low 5-year survival rate. Due to the lack of therapeutic targets, the targeted drugs for HNSCC are rare. Therefore, exploring the regulation mechanism of HNSCC and identifying effective therapeutic targets will be beneficial to its treatment of. Circular RNA (CircRNA) is a class of RNA molecules with a circular structure, which is widely expressed in human body. CircRNAs regulate gene expression by exerting the function as a miRNA sponge, thereby mediating the occurrence and development of HNSCC cell proliferation, apoptosis, migration, invasion, and other processes. In addition, circRNAs are also involved in the regulation of tumor sensitivity to chemical drugs and other biological functions. In this review, we systematically listed the functions of circRNAs and explored the regulatory mechanisms of circRNAs in HNSCC from the aspects of tumor growth, cell death, angiogenesis, tumor invasion and metastasis, tumor stem cell regulation, tumor drug resistance, immune escape, and tumor microenvironment. It will assist us in discovering new diagnostic markers and therapeutic targets, while encourage new ideas for the diagnosis and treatment of HNSCC.

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Peripheral blood circular RNA hsa_circ_0058493 as a potential novel biomarker for silicosis and idiopathic pulmonary fibrosis

Cited by 25 publications

References 46 publications

The emerging role of epigenetic regulation in the progression of silicosis

The emerging role of epigenetic regulation in the progression of silicosis

Circular RNAs in organ injury: recent development

CircRNAs: Roles in regulating head and neck squamous cell carcinoma

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