Peripheral blood CD40–CD40L expression in human breast cancer

Pan, Wen; Ju, Gong; Yang, Chengli; Feng, Rentian; Guo, Feng; Y, Sun; Chen, H.

doi:10.1007/s11845-013-0931-0

Cited by 12 publications

(9 citation statements)

References 8 publications

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“…In accordance, the expression levels of CD40/CD40L have also been found to be increased in breast cancer, displaying a positive relationship with pathological grade [55]. A recent study, showed that the production of TGF-β induced by the CD40-CD40L interaction resulted in enhanced immunosuppressive function of breast cancer cells, thereby contributing to tumor progression [55]. …”

Section: Discussionmentioning

confidence: 85%

Tumor tissue protein signatures reflect histological grade of breast cancer

et al. 2017

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Histological grade is one of the most commonly used prognostic factors for patients diagnosed with breast cancer. However, conventional grading has proven technically challenging, and up to 60% of the tumors are classified as histological grade 2, which represents a heterogeneous cohort less informative for clinical decision making. In an attempt to study and extend the molecular puzzle of histologically graded breast cancer, we have in this pilot project searched for additional protein biomarkers in a new space of the proteome. To this end, we have for the first time performed protein expression profiling of breast cancer tumor tissue, using recombinant antibody microarrays, targeting mainly immunoregulatory proteins. Thus, we have explored the immune system as a disease-specific sensor (clinical immunoproteomics). Uniquely, the results showed that several biologically relevant proteins reflecting histological grade could be delineated. In more detail, the tentative biomarker panels could be used to i) build a candidate model classifying grade 1 vs. grade 3 tumors, ii) demonstrate the molecular heterogeneity among grade 2 tumors, and iii) potentially re-classify several of the grade 2 tumors to more like grade 1 or grade 3 tumors. This could, in the long-term run, lead to improved prognosis, by which the patients could benefit from improved tailored care.

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Section: Discussionmentioning

confidence: 85%

Tumor tissue protein signatures reflect histological grade of breast cancer

et al. 2017

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“…The reason why post-CRT sCD40L levels are significantly reduced in High-R is not known, but it is known that, in addition to the immunomodulatory effects, the CD40 signaling pathway also plays an important role in proliferation, differentiation and apoptosis of cancer cells. Many tumor cells also express CD40 (29)(30)(31)(32), and evidence suggests that ligation of CD40 might promote either cell proliferation or apoptosis, depending on the intensity of CD40L signaling (33,34). Although we did not investigate the expression of CD40 in cancer cells, it can be speculated that sCD40L may induce antitumor effects, either through binding to immune cells, stimulating an antitumor immunity, or through the direct binding to cancer cells, inducing their apoptotic cell death; in both situations, sCD40L levels are reduced by consumption.…”

Section: D Venous Invasionmentioning

confidence: 99%

Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients

et al. 2013

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In the present study, we aimed to characterize the predictive value of cytokines/chemokines in rectal cancer (RC) patients receiving chemoradiation therapy (CRT). Blood samples were obtained pre- and post-CRT from 35 patients with advanced RC, who received neoadjuvant CRT followed by surgery, and the correlation between plasma levels of cytokines/chemokines and the response to CRT was analyzed. The pre-CRT levels of soluble CD40-ligand (sCD40L) and the post-CRT levels of chemokine ligand-5 (CCL-5) were significantly associated with the depth of tumor invasion and with venous invasion. In addition, a significant decrease in sCD40L and CCL-5, as well as in platelet counts, was associated with a favorable response to CRT. A significant correlation between pre-CRT platelet counts and sCD40L was observed in patients with a favorable response. By contrast, higher post-CRT interleukin (IL)-6 was associated with a poor response. Platelets, immune system and cancer cells, cross-linked through various cytokines/chemokines, appear to play an important role in the response to CRT, and by understanding their roles, new approaches for the improvement of the therapy might be proposed.

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“…CD40L, which is a type II membrane-related glycoprotein and a member of the tumor necrosis factor (TNF) superfamily [22], is conducive to regulate the immune response and inhibit tumor growth. It produces direct growth-inhibiting effect through apoptosis in CD40L over-expressed malignant tumor cells (such as breast cancer) [23]. The correlation of ICGs expression level in both databases is positive and is showing an obvious aggregation effect, indicating a possibility of coordinated expression relationship between ICGs.…”

Section: Discussionmentioning

confidence: 95%

Identification of immune prognostic signature of lung carcinoma based on Genome-wide immune expression profile

Ling

Zhao

et al. 2020

Preprint

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Background : Lung cancer is one of the most common types of cancer with low early diagnosis rate and poor prognosis. The integration of immune checkpoint gene expression data and patient prognosis information can help identify the immune subtypes of lung cancer and provide reference for individualized gene immunotherapy in patients with lung cancer. Methods : The data of immune gene expression for lung cancer patients were obtained from TCGA and GEO databases. The relationship between the expressions of 45 immune checkpoint genes (ICGs) and prognosis were analysed. In the other hand, the correlation between the expressions of 45 biomarkers , tumor mutation load (TMB), MMRs, neoantigens and other immunotherapy biomarkers were been identified. Ultimately, prognosis-related ICGs were combined with IDO1, CD274, and CTLA4 to divide lung cancer immune subgroups and the prognostic differences between lung cancer immune subgroups were identified. Results: Based on TCGA database and GEO database, 9 and 11 ICGs were obtained respectively, which were closely related to prognosis. There was a certain synergistic relationship between them. The expression of CD200R1 had a significant negative correlation with TMB and neoantigens. CD200R1 showed a significant positive correlation with CD8A, CD68 and GZMB genes, indicating that it may cause the expression disorder of adaptive immune resistance pathway genes. Based on CD200R1 and combination with IDO1, CD274 and CTLA4, the group with high expression of CD200R1 and low expression of IDO1, CD274 and CTLA4 had the best prognosis among the immune subtypes. Conclusion : Our research provides a method of integrating immune checkpoint gene expression profile and clinical prognosis information to identify immune subtypes of lung cancer, which can provide a unique reference for gene immunotherapy of lung cancer patients.

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Peripheral blood CD40–CD40L expression in human breast cancer

Abstract: The upregulated levels of co-stimulators CD40/CD40L on B cells and T cells may play an important role in the immune pathogenesis of breast cancer.

Cited by 12 publications

References 8 publications

Tumor tissue protein signatures reflect histological grade of breast cancer

Tumor tissue protein signatures reflect histological grade of breast cancer

Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients

Identification of immune prognostic signature of lung carcinoma based on Genome-wide immune expression profile

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