Peripheral blood CD4/ T cells in systemic lupus erythematosus

Horwitz, David A.

doi:10.1191/096120301676469109

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…For example, we did not distinguish CD4 and CD8 lymphocytes in the CD3ϩ cells, or the expression of CD27 in CD20ϩ cells (to distinguish memory from naïve B lymphocytes). 28 Although these cell markers have been extensively studied in peripheral blood mononuclear cells in SLE patients, [29][30][31] their relevance in urinary sediment has not been examined. A previous report by Yamamoto et al 13 indicated that CD8 cell was the predominant species of T lymphocytes in the urine of SLE patients.…”

Section: Lupusmentioning

confidence: 99%

Urinary mononuclear cell and disease activity of systemic lupus erythematosus

Chan

Lai

et al. 2006

Lupus

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Mononuclear cells play a cardinal role in the pathogenesis of systemic lupus erythematosus (SLE). A high urine cytology score has been reported to be associated with lupus nephritis in relapse. The objective of this study was to examine the urinary mononuclear cell population of patients with lupus nephritis, and explore its correlation with lupus disease activity. We studied 12 patients with active lupus nephritis, 17 patients with lupus nephritis in remission, 12 SLE patients with no history of renal disease and 13 healthy subjects. Clinical disease activity was quantified by the SLE Disease Activity Index (SLEDAI). Mononuclear cell species in the urinary sediment were examined by immunocytochemistry. Patients with active lupus nephritis had significantly more mononuclear cells in the urinary sediment. The number of CD3+ cell was significantly elevated in the active lupus nephritis than the others (P < 0.001), while there was no significant difference in the number of CD20+ and CD56+ cell among patient groups. The total urinary mononuclear cell correlated significantly with the overall SLEDAI score (r = 0.58, P < 0.001) as well as the renal score (r = 0.57, P < 0.001). The number of urinary CD3+, but not CD20+ or CD56+, cell significantly correlated with the overall SLEDAI score (r = 0.46, P = 0.003) as well as the renal score (r = 0.40, p = 0.011). In nine patients with renal biopsy, the histological activity index correlated with the total urinary mononuclear cell (r = 0.75, P = 0.02), CD3+ (r = 0.69, P = 0.04) and CD20+ cell (r = 0.69, P = 0.04). We conclude that urinary mononuclear cell was markedly elevated in patients with active lupus, and the urinary mononuclear cell count correlated significantly with the SLEDAI score and histological activity. CD3+ and CD20+ cells are the major component of urinary mononuclear cell in SLE patients and their number correlates with lupus disease activity.

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Section: Lupusmentioning

confidence: 99%

Urinary mononuclear cell and disease activity of systemic lupus erythematosus

Chan

Lai

et al. 2006

Lupus

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“…These pathogenic autoantibodies are produced by plasma cells differentiated from activated autoreactive B cells. As a T-lymphocyte subset, CD4+ T cells provide "help" to B cells to produce autoantibodies and promote inflammation, and is reported to be the predominant helper subset and the strongest inducer of autoantibodies 2 . In addition, CD4+ T cells are considered pivotal in the development and maintenance of protective immunity and tolerance, and imbalances in these processes can lead to autoimmunity 3,4 .…”

mentioning

confidence: 99%

Role of MiR-98 and Its Underlying Mechanisms in Systemic Lupus Erythematosus

Xie

2018

J Rheumatol

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“…Although several of the mouse models are also characterized by elevated CD4:CD8 ratios, this has not been a characteristic feature of human SLE (reviewed in Ref. 25). Experiments involving knockouts, Ab-mediated blocking, and in vitro cultures have clearly demonstrated the critical role played by Th cells in driving B cell autoantibody production in murine and human lupus (26 -32).…”

Section: Discussionmentioning

confidence: 99%

Genetic Dissection of Sle Pathogenesis:Sle3on Murine Chromosome 7 Impacts T Cell Activation, Differentiation, and Cell Death

Mohan

Morel

et al. 1999

The Journal of Immunology

147

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Polyclonal, generalized T cell defects, as well as Ag-specific Th clones, are likely to contribute to pathology in murine lupus, but the genetic bases for these mechanisms remain unknown. Mapping studies indicate that loci on chromosomes 1 (Sle1), 4 (Sle2), 7 (Sle3), and 17 (Sle4) confer disease susceptibility in the NZM2410 lupus strain. B6.NZMc7 mice are C57BL/6 (B6) mice congenic for the NZM2410-derived chromosome 7 susceptibility interval, bearing Sle3. Compared with B6 controls, B6.NZMc7 mice exhibit elevated CD4:CD8 ratios (2.0 vs 1.34 in 1- to 3-mo-old spleens); an age-dependent accumulation of activated CD4+ T cells (33.4% vs 21.9% in 9- to 12-mo-old spleens); a more diffuse splenic architecture; and a stronger immune response to T-dependent, but not T-independent, Ags. In vitro, Sle3-bearing T cells show stronger proliferation, increased expansion of CD4+ T cells, and reduced apoptosis (with or without anti-Fas) following stimulation with anti-CD3. With age, the B cells in this strain acquire an activated phenotype. Thus, the NZM2410 allele of Sle3 appears to impact generalized T cell activation, and this may be causally related to the low grade, polyclonal serum autoantibodies seen in this strain. Epistatic interactions with other loci may be required to transform this relatively benign phenotype into overt autoimmunity, as seen in the NZM2410 strain.

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Peripheral blood CD4/ T cells in systemic lupus erythematosus

Cited by 6 publications

References 24 publications

Urinary mononuclear cell and disease activity of systemic lupus erythematosus

Urinary mononuclear cell and disease activity of systemic lupus erythematosus

Role of MiR-98 and Its Underlying Mechanisms in Systemic Lupus Erythematosus

Genetic Dissection of Sle Pathogenesis:Sle3on Murine Chromosome 7 Impacts T Cell Activation, Differentiation, and Cell Death

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