Peripheral blood CD4+/CD25+ regulatory T cells in alcoholic patients with Strongyloides stercoralis infection

Ribeiro, Steveen Rios; Covre, Luciana Polaco; Stringari, Lorenzzo Lyrio; Zago-Gomes, Maria da Penha; Gomes, Daniel Cláudio Oliveira; Pereira, Fausto Edmundo Lima

doi:10.1007/s00436-016-5355-0

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…Ribeiro et al demonstrated an increase in T regulatory cells in alcoholic patients, both infected and non‐infected, with S. stercoralis , as well as in non‐alcoholic infected individuals, 27 which suggests that both alcoholism and S. stercoralis infection increase the frequency of these cells. In this study, the levels of IL‐10 in alcoholic patients infected or non‐infected with S. stercora lis did not show statistical differences when compared to non‐alcoholic groups.…”

Section: Discussionmentioning

confidence: 99%

Modulation of circulating cytokine production in alcoholic patients infected with Strongyloides stercoralis

Souza

Oliveira

et al. 2023

Parasite Immunology

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Strongyloidiasis control is associated with a Th2 immune response. However, alcohol ingestion plays an important role in modulating the immune system. The aim of this study is to evaluate the occurrence of Strongyloides stercoralis infection in alcoholic patients, the levels of circulating cytokines (IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-15 and IL-17), and its correlation with modulation of parasitic load in alcoholic individuals infected with S. stercoralis. A total of 336 alcoholic patients, treated at the Alcoholic Care and Treatment Center were included in this study. The cytokine levels were measured by a commercial ELISA in 80 sera divided into four groups with 20 individuals each: alcoholics infected (ASs+) and not infected (ASs-) with S. stercoralis and non-alcoholics infected (NASs+) and not infected (NASs-) with the helminth.S. stercoralis frequency in alcoholic patients was 16.1% (54/336). The parasitic load varied from 1 to 546 larvae/g of faeces, median and interquartile range (IQR) of 9 and 1.0-62.5 larvae/g of faeces, while in non-alcoholic individuals the parasitic load was less than 10 larvae/g of faeces. Levels of circulating IL-4 were significantly higher in ASs+ when compared with NASs-group (p < .05). An inverse correlation between serum levels of IFN-γ and parasitic load in alcoholic patients infected with S. stercoralis was observed (r = À601; p < 0.01). These results suggest that modulation of IFN-γ production occurs in alcoholic individuals with high parasitic burden.

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Section: Discussionmentioning

confidence: 99%

Modulation of circulating cytokine production in alcoholic patients infected with Strongyloides stercoralis

Souza

Oliveira

et al. 2023

Parasite Immunology

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“…Perhaps this is why hematologists were less enthusiastic about the clinical marker discovery of hormone resistance in ITP patients. However, the annual incidence of adult ITP is 5 to 10/10 million [4,[16][17][18], and the incidence of GCs resistance in these patients is 30%. For China's huge population base, therefore, steroid resistance is a problem that cannot be ignored due to side effects caused by GC therapy (e.g., Cushing features, osteoporosis, and other toxicities) [21].…”

Section: Discussionmentioning

confidence: 99%

“…Covariates involved in this present work can be summarized as demographic data, general information, our prior work, previous literature, and clinical experiences [17][18][19][20]. Therefore, the following variables were used to construct the fully-adjusted model: sex, age, height, weight, smoking status, drink habits, Helicobacter pylori burden, comorbidities (type 2 diabetes, cardiovascular disease, hyperuricemia), mean platelet volume (MPV), bleeding symptoms (skin, mucosa, organ), first-line treatment strategy (oral prednisone, high-dose dexamethasone) and mean platelet distribution (MPD) at diagnosis.…”

Section: Variablesmentioning

confidence: 99%

Platelet to Lymphocyte Ratio and Glucocorticoid Resistance in Newly Diagnosed Primary Immune Thrombocytopenia: A Retrospective Cohort Study

et al. 2019

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Background: In China, evidence regarding to the association between platelet to lymphocyte ratio (PLR) and glucocorticoid (GC) resistance in participants with primary newly identified immune thrombocytopenia (ITP) is limited. We aimed to investigate whether PLR is independently linked with GC-resistant ITP. Material/Methods: We non-selectively and consecutively collected 154 newly diagnosed ITPs. The start enrollment time and the end enrollment time were from March 2013 to June 2017. The independent and dependent variables were PLR measured at diagnosis and GC non-response. Other variables involved in the present work can be summarized as demographic data and factors that were correlated with PLR reported by published studies. Univariate and multivariate binary logistic regression model and sensitivity analysis were used to evaluate the associations between PLR and GC resistance. Results: After adjusting covariates, PLR level was negatively associated with GC non-response [odds ratio (OR)=0.89, 95% confidence intervals (CI): 0.80 to 0.98], and supported by propensity score matching model (OR=0.74, 95%CI: 0.57 to 0.96]. Nonlinearity of PLR and GC resistance was observed whose inflection point was 5.08 (by 2-piecewise model). The OR and 95%CI on both sides of inflection point were 3.14 (0.81 to 12.21) and 0.81 (0.69 to 0.95), respectively. Subgroup analysis showed no significant differences from subgroups. Conclusions: Threshold effect on PLR and GC resistance is observed. When PLR is larger than 5.08, a unit increase of PLR is independently associated with 19% reduction of GC resistance.

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“…It was evident by the enhanced CD4 + FOXP3 + and CD25 + FOXP3 + Treg cell subtypes which were prompted in mice immunized with DCs, isolated from ethanol-fed mice, and loaded with HCV core (Ortiz and Wands, 2014). In contrast to decreased circulatory CD4 + /CD25 + Treg cells in alcoholic patients (Almeida et al, 2013), another study reported an increased population of circulatory CD4 + /CD25 + Treg cells in alcoholic patients (Ribeiro et al, 2017), suggested the role of Treg cells in reducing the detrimental effects of excessive alcohol intake on the liver. Meanwhile, it has been investigated that inflammatory immune response in ALD has resulted from the increased Th17 population (Kasztelan-Szczerbińska et al, 2015), and Treg cells reduce the development and differentiation of Th17 cells by modulating the levels of anti-inflammatory IL-10 and TGF-β cytokines (Chaudhry et al, 2011;O'Garra and Vieira, 2004;Lee, 2018).…”

Section: Role Of Treg In Alcoholic Liver Diseasementioning

confidence: 99%

Fine-tuning of regulatory T cells is indispensable for the metabolic steatosis-related hepatocellular carcinoma: A review

Riaz

Wei

Fan

2022

Front. Cell Dev. Biol.

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The majority of chronic hepatic diseases are caused by nutritional imbalance. These nutritional inequities include excessive intake of alcohol and fat, which causes alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), respectively. The pathogenesis of hepatic diseases is mainly dependent on oxidative stress, autophagy, DNA damage, and gut microbiota and their metabolites. These factors influence the normal physiology of the liver and impact the hepatic microenvironment. The hepatic microenvironment contains several immune cells and inflammatory cytokines which interact with each other and contribute to the progression of chronic hepatic diseases. Among these immune cells, Foxp3+ CD4+ regulatory T cells (Tregs) are the crucial subset of CD4+ T cells that create an immunosuppressive environment. This review emphasizes the function of Tregs in the pathogenesis of ALD and NAFLD and their role in the progression of NAFLD-associated hepatocellular carcinoma (HCC). Briefly, Tregs establish an immunosuppressive landscape in the liver by interacting with the innate immune cells and gut microbiota and their metabolites. Meanwhile, with the advancement of steatosis, these Tregs inhibit the proliferation, activation and functions of other cytotoxic T cells and support the progression of simple steatosis to HCC. Briefly, it can be suggested that targeting Tregs can act as a favourable prognostic indicator by modulating steatosis and insulin resistance during the pathogenesis of hepatic steatosis and NAFLD-associated HCC.

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Peripheral blood CD4+/CD25+ regulatory T cells in alcoholic patients with Strongyloides stercoralis infection

Cited by 4 publications

References 14 publications

Modulation of circulating cytokine production in alcoholic patients infected with Strongyloides stercoralis

Modulation of circulating cytokine production in alcoholic patients infected with Strongyloides stercoralis

Platelet to Lymphocyte Ratio and Glucocorticoid Resistance in Newly Diagnosed Primary Immune Thrombocytopenia: A Retrospective Cohort Study

Fine-tuning of regulatory T cells is indispensable for the metabolic steatosis-related hepatocellular carcinoma: A review

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