Peripheral Blood CD161<sup>+</sup> T Cells from Asthmatic Patients are Activated During Asthma Attack and Predominantly Produce IFN‐<i>γ</i>

González, Yolanda; Pedraza-Sánchez, Sigifredo; Blandón-Vijil, Virginia; Río-Navarro, Blanca Estela Del; Vaughan, Gilberto; Moreno-Lafont, Martha; Escobar‐Gutiérrez, Alejandro

doi:10.1111/j.1365-3083.2006.01885.x

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…No previous study has reported the frequency of the resident CD3 + CD161 + T cell subset under non-inflamed conditions in bronchoalveolar space. The frequency of CD161 + cells that we observed in the blood was consistent with previous reports [ 8 , 21 – 23 ]. The frequency of CD3 + CD161 + T cells has been assessed and was found at increased proportions in the liver, colon, epithelium, and duodenum [ 8 – 10 ]; however, these studies were performed on patients with cancer, and those who had undergone liver transplantation or had gastrointestinal symptoms [ 24 ].…”

Section: Discussionsupporting

confidence: 93%

CD161 Expression Defines a Th1/Th17 Polyfunctional Subset of Resident Memory T Lymphocytes in Bronchoalveolar Cells

González¹,

Herrera²,

Juárez³

et al. 2015

PLoS ONE

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Alveolar resident memory T cells (TRM) comprise a currently uncharacterized mixture of cell subpopulations. The CD3+CD161+ T cell subpopulation resides in the liver, intestine and skin, but it has the capacity for tissue migration; however, the presence of resident CD3+CD161+ T cells in the bronchoalveolar space under normal conditions has not been reported. Bronchoalveolar cells (BACs) from healthy volunteers were evaluated and found that 8.6% (range 2.5%-21%) of these cells were CD3+ T lymphocytes. Within the CD3+ population, 4.6% of the cells (2.1–11.3) expressed CD161 on the cell surface, and 74.2% of the CD161+CD3+ T cells expressed CD45RO. The number of CD3+CD161+ T cells was significantly lower in the bronchoalveolar space than in the blood (4.6% of BACs vs 8.4% of peripheral blood mononuclear cells (PBMCs); P<0.05). We also found that 2.17% of CD4+ T lymphocytes and 1.52% of CD8+ T lymphocytes expressed CD161. Twenty-two percent of the alveolar CD3+CD161+ T lymphocytes produced cytokines upon stimulation by PMA plus ionomycin, and significantly more interferon gamma (IFN-γ) was produced compared with other cytokines (P = 0.05). Most alveolar CD3+CD161+ T cells produced interleukin-17 (IL-17) and IFN-γ simultaneously, and the percentage of these cells was significantly higher than the percentage of CD3+CD161− T cells. Moreover, the percentage of alveolar CD3+CD161+ T lymphocytes that produced IFN-γ/IL-17 was significantly higher than those in the peripheral blood (p<0.05). In conclusion, Th1/Th17-CD3+CD161+ TRM could contribute to compartment-specific immune responses in the lung.

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Section: Discussionsupporting

confidence: 93%

CD161 Expression Defines a Th1/Th17 Polyfunctional Subset of Resident Memory T Lymphocytes in Bronchoalveolar Cells

González¹,

Herrera²,

Juárez³

et al. 2015

PLoS ONE

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“…In this study, CD161 + T-cells and CD94 + T-cells accounted for approximately 12% of the total CD3 + T-cell population in healthy subjects, consistent with previous reports [41–43]. There were fewer CD56 + T-cells than either CD161 + T-cells or CD94 + T-cells; again consistent with previous findings [44].…”

Section: Discussionsupporting

confidence: 92%

T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to α-galactosylceramide are impaired

O’Keeffe

Gately

Counihan

et al. 2008

Journal of the Neurological Sciences

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Multiple sclerosis (MS) is an autoimmune disorder characterised by clinical relapse and remission and pathological demyelination with varying inflammation. Because it is suggested that T-cells expressing natural killer cell receptors (NKR) play important roles in regulating human autoimmune diseases, we have quantified populations T-cells expressing the NKR CD56, CD161 and CD94 in the peripheral blood of MS patients, in healthy control subjects (HS) and in patients with other neurological diseases (OND). CD161 + T-cells and CD94 + T-cells were significantly decreased in MS patients with primary progressive disease and secondarily change progressive disease respectively whereas CD56 + T-cell numbers were unchanged. In contrast NKT-cells that express the invariant V α 24-J α 18 + T-cell receptor identified here by specific receptor antibody and CD1d-tetrameric PBS57-loaded complexes, were increased in MS patients compared with HS. Reductions in CD161 + T-cells and CD94 + T cells relative to HS were also observed in the OND group and this was particularly prominent in Parkinsonian patients. A striking functional finding was that while NKT-cells in unfractionated peripheral blood from healthy subjects expanded in number and produced IFN-γ upon stimulation with α-galactosylceramide, NKT-cells from MS patients did not. Thus we have identified alterations in a number of potentially important lymphocyte sub-populations warranting further investigation in the immune response in MS.

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“…Due to the systemic involvement, asthma exacerbation can also be monitored or even predicted by urinary metabolites including arachidonic derivatives such as leukotrienes (184,185) and urinary trypsin inhibitor (186). Exacerbated allergic asthma is accompanied with increased BAL levels of quinolinic acid, tryptophan, ECP, eosinophils (187), decreased CD29 (32) and CD44 (188) on eosinophils and elevated CD203c expression on basophils, which decreases significantly during remission (101 (189). While early or mild conditions are well-reflected local biomarkers, it appears that moderate to severe disease conditions are even visible in the peripheral blood.…”

Section: Biomarkers For Disease Severity and Exacerbationmentioning

confidence: 99%

Current and future biomarkers in allergic asthma

Zissler

Bieren

Jakwerth

et al. 2016

Allergy

105

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Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment progression are key motivations for the exploration of biomarkers for allergic rhinitis and allergic asthma. The number of genes related to allergic rhinitis and allergic asthma increases steadily; however, prognostic genes have not yet entered clinical application. We hypothesize that the combination of multiple genes may generate biomarkers with prognostic potential. The current review attempts to group more than 161 different potential biomarkers involved in respiratory inflammation to pave the way for future classifiers. The potential biomarkers are categorized into either epithelial or infiltrate-derived or mixed origin, epithelial biomarkers. Furthermore, surface markers were grouped into cell-typespecific categories. The current literature provides multiple biomarkers for potential asthma endotypes that are related to T-cell phenotypes such as Th1, Th2, Th9, Th17, Th22 and Tregs and their lead cytokines. Eosinophilic and neutrophilic asthma endotypes are also classified by epithelium-derived CCL-26 and osteopontin, respectively. There are currently about 20 epithelium-derived biomarkers exclusively derived from epithelium, which are likely to innovate biomarker panels as they are easy to sample. This article systematically reviews and categorizes genes and collects current evidence that may promote these biomarkers to become part of allergic rhinitis or allergic asthma classifiers with high prognostic value.

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Peripheral Blood CD161⁺ T Cells from Asthmatic Patients are Activated During Asthma Attack and Predominantly Produce IFN‐γ

Cited by 10 publications

References 30 publications

CD161 Expression Defines a Th1/Th17 Polyfunctional Subset of Resident Memory T Lymphocytes in Bronchoalveolar Cells

CD161 Expression Defines a Th1/Th17 Polyfunctional Subset of Resident Memory T Lymphocytes in Bronchoalveolar Cells

T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to α-galactosylceramide are impaired

Current and future biomarkers in allergic asthma

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Peripheral Blood CD161+ T Cells from Asthmatic Patients are Activated During Asthma Attack and Predominantly Produce IFN‐γ

Cited by 10 publications

References 30 publications

CD161 Expression Defines a Th1/Th17 Polyfunctional Subset of Resident Memory T Lymphocytes in Bronchoalveolar Cells

CD161 Expression Defines a Th1/Th17 Polyfunctional Subset of Resident Memory T Lymphocytes in Bronchoalveolar Cells

T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to α-galactosylceramide are impaired

Current and future biomarkers in allergic asthma

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Peripheral Blood CD161⁺ T Cells from Asthmatic Patients are Activated During Asthma Attack and Predominantly Produce IFN‐γ