Peripheral Biomarkers of Inflammation in Depression: Evidence from Animal Models and Clinical Studies

Brás, João; Pinto, Soraia; Almeida, Maria Inês; Prata, Joana; Doellinger, Orlando von; Coelho, Rui; Barbosa, Mário A.; Santos, Susana G.

doi:10.1007/978-1-4939-9554-7_28

Cited by 15 publications

(15 citation statements)

References 203 publications

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“…The neuroinflammatory response involves the whole process of the occurrence and development of stroke, and it has an adverse effect on complications, including depression [ 30 , 31 ]. Adjusting the inflammatory response could improve the symptoms of depression after stroke [ 32 ]. NF- κ B is a transcription factor that accumulates in the cytoplasm in the form of a dimer in a resting state.…”

Section: Discussionmentioning

confidence: 99%

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF-κB Pathway to Improve Poststroke Depression

Wang

Han

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The neuroinflammatory pathway regulated by nuclear factor kappa-B (NF-κB) plays an important role in the occurrence, development, and prognosis of poststroke depression (PSD). The regulatory effect of the traditional Chinese medicine compound Xingnao Jieyu decoction (XNJY) on the NF-κB pathway of PSD is still unclear. This study aimed to observe the effect of XNJY on PSD and explore the molecular mechanism of its intervention in the NF-κB pathway. Middle cerebral artery occlusion (MCAO) and chronic unpredictable mild stress were used to establish a PSD rat model. Body mass measurement, behavioral testing, Nissl staining, ELISA, and Western blot were also performed. XNJY and fluoxetine hydrochloride (Flu) treatment of PSD model rats showed significant antidepressant effects. XNJY and Flu treatment could reduce cortical and hippocampal neuronal damage. XNJY reduced inflammation and restored the levels of IL-4, IL-10, and BDNF. In addition, XNJY showed a significant regulatory effect on the NF-κB pathway and the expression of synapse-related proteins PSD-95 and SYN. These results showed that XNJY could significantly reduce the depressive symptoms of PSD rats, and this reduction may be related to the regulation of the NF-κB signaling pathway to improve neuroinflammation and synaptic function.

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Section: Discussionmentioning

confidence: 99%

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF-κB Pathway to Improve Poststroke Depression

Wang

Han

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…It is well known that some pro-inflammatory biomarkers, including interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP), are commonly increased in diabetes [110] and depression [111], and evidence indicates that depression and T2DM share biological mechanisms, namely, overactivation of the immune response, leading to a cytokine-mediated inflammatory response [112]. TNF-α is one of the most thoroughly studied pro-inflammatory biomarkers for both depression and T2DM.…”

Section: Immune/inflammatory Oxidative and Nitrosative Stressmentioning

confidence: 99%

Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression—A Literature Review

Woo

Lim

Wang

et al. 2020

IJMS

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Close connections between depression and type 2 diabetes (T2DM) have been suggested by many epidemiological and experimental studies. Disturbances in insulin sensitivity due to the disruption of various molecular pathways cause insulin resistance, which underpins many metabolic disorders, including diabetes, as well as depression. Several anti-hyperglycemic agents have demonstrated antidepressant properties in clinical trials, probably due to their action on brain targets based on the shared pathophysiology of depression and T2DM. In this article, we review reports of clinical trials examining the antidepressant effect of these medications, including insulin, metformin, glucagon like peptide-1 receptor agonists (GLP-1RA), and peroxisome proliferator-activated receptor (PPAR)-γ agonists, and briefly consider possible molecular mechanisms underlying the associations between amelioration of insulin resistance and improvement of depressive symptoms. In doing so, we intend to suggest an integrative perspective for understanding the pathophysiology of depression.

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“…In particular, hs-CRP is used as an indicator to assess the risk of cardiovascular disease (CVD), and several studies have suggested hs-CRP as a predictor of mortality. In assessing CVD risk, the American Heart Association (AHA) and Centers for Disease Control and Prevention (CDC) de ned hs-CRP levels of >3.0 mg/L to indicate high risk, 1.0-3.0 mg/L to indicate average risk, and <1.0 mg/L to indicate low risk [4,5].…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the association between self-rated health and high-sensitivity C-reactive protein levels in Koreans: A cross-sectional study using data from the Korea National Health and Nutrition Examination Survey

Park

Kim

et al. 2020

Preprint

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Background: No studies have investigated the association between self-rated health (SRH) and high-sensitivity C-reactive protein (hs-CRP) levels in South Koreans. We explored this association and analyzed differences between sexes. Methods: Using cross-sectional data from the 2015–2017 Korea National Health and Nutrition Examination Survey, we analyzed the association between SRH and high hs-CRP levels (>1.0 mg/L) in 14,544 Koreans aged ≥19 years who responded to the SRH survey and had available hs-CRP test results. Differences in sociodemographic factors were analyzed using the Pearson’s chi-square test for categorical variables or the Mann-Whitney U test for continuous variables. Multiple logistic regression analysis was used to measure the association between hs-CRP levels and SRH according to sex while adjusting for other possible confounders.Results: The percentage of very poor to poor SRH was higher in the high hs-CRP group (22.4%) than in the low hs-CRP group (17.66%). Among men, the risk of a high hs-CRP level increased with worse SRH (adjusted for confounders; P for trend <0.001). After adjusting for all confounders, including chronic diseases, men with very poor SRH showed a higher odds ratio (OR) for high hs-CRP levels than those with very good SRH (fully adjusted OR, 1.74; 95% confidence interval, 1.04–2.90). Significant correlations were absent among women. Conclusions: Poor SRH was correlated with low-grade inflammation (high hs-CRP levels) among Korean male adults. These findings could be useful for developing health improvement programs and in goal setting at a national scale.

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Peripheral Biomarkers of Inflammation in Depression: Evidence from Animal Models and Clinical Studies

Cited by 15 publications

References 203 publications

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF-κB Pathway to Improve Poststroke Depression

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF-κB Pathway to Improve Poststroke Depression

Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression—A Literature Review

Sex differences in the association between self-rated health and high-sensitivity C-reactive protein levels in Koreans: A cross-sectional study using data from the Korea National Health and Nutrition Examination Survey

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