Peripheral benzodiazepine receptors are decreased during cocaine withdrawal in humans

Javaid, Javaid I.; Notorangelo, Michael P.; Pandey, Subhash C.; Reddy, Poluru L.; Pandey, Ghanshyam N.; Davis, John M.

doi:10.1016/0006-3223(94)90061-2

Cited by 9 publications

(2 citation statements)

References 32 publications

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“…In humans, the number of benzodiazepine receptors in platelets from chronic cocaine users is augmented when compared to those obtained from alcoholics or normal controls (Chesley et al 1990). In addition, peripheral benzodiazepine receptors labeled with [ 3 H]PK11195 were decreased in neutrophil membranes from the blood of male inpatients following 3 weeks of cocaine abstinence (Javaid et al 1994). These data indicate that benzodiazepine receptors may mediate some of the effects of cocaine in humans.…”

Section: Discussionmentioning

confidence: 95%

Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats

et al. 2008

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Section: Discussionmentioning

confidence: 95%

Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats

et al. 2008

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“…Similarly, Ritsner et al, [2003] found a 30% decrease in platelet [ 3 H]PK11195 Bmax in aggressive schizophrenia relative to controls. Studies in peripheral cells from alcoholics, cocaine dependence, and after suicide attempts in schizophrenia subjects indicate that these factors can decrease [ 3 H]PK11195 Bmax in peripheral cells [Suranyi-Cadotte et al, 1988;Javaid et al, 1994]. Collectively, all of these studies provided evidence of no change in peripheral cell [ 3 H]PK11195 Bmax or Kd in unmedicated schizophrenia subjects relative to healthy controls but schizophrenia with specific classifications or co-morbidity factors decreased peripheral cell [ 3 H]PK11195 Bmax with no change in Kd.…”

Section: Tspo Studies In Schizophrenia Prior To Pet Imaging-a Historimentioning

confidence: 97%

TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward

Guilarte

2019

Pharmacology & Therapeutics

131

127

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The use of Translocator Protein 18 kDa (TSPO) as a clinical neuroimaging biomarker of brain injury and neuroinflammation has increased exponentially in the last decade. There has been a furious pace in the development of new radiotracers for TSPO positron emission tomography (PET) imaging and its use has now been extensively described in many neurological and mental disorders. This fast pace of research and the ever-increasing number of new laboratories entering the field often times lack an appreciation of the historical perspective of the field and introduce dogmatic, but unproven facts, related to the underlying neurobiology of the TSPO response to brain injury and neuroinflammation. Paradoxically, while in neurodegenerative disorders and in all types of CNS pathologies brain TSPO levels increase, a new observation in psychiatric disorders such as schizophrenia is decreased brain levels of TSPO measured by PET. The neurobiological bases for this new finding is currently not known, but rigorous experimental design using multiple experimental approaches and careful interpretation of results is critically important to provide the methodological and/or biological underpinnings to this new observation. This review provides a perspective of the early history of validating TSPO as a biomarker of brain injury and neuroinflammation and a critical analysis of controversial topics in the literature related to the cellular sources of the TSPO response. The latter is important in order to provide the correct interpretation of PET studies in neurodegenerative and psychiatric disorders. Furthermore, this review proposes some yet to be explored explanations to new findings in psychiatric disorders and new approaches to quantitatively assess the glial sources of the TSPO response in order to move the field forward.

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Assessing Effects of Neurotoxic Pollutants by Biochemical Markers

Manzo

Castoldi

Coccini

et al. 2001

Environmental Research

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Peripheral benzodiazepine receptors are decreased during cocaine withdrawal in humans

Cited by 9 publications

References 32 publications

Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats

Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats

TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward

Assessing Effects of Neurotoxic Pollutants by Biochemical Markers

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