Peripheral artery disease, lower limb revascularization, and amputation in diabetes patients with and without coronary artery disease: a cohort study from the Western Denmark Heart Registry

Olesen, Kevin Kris Warnakula; Gyldenkerne, Christine; Thim, Troels; Thomsen, Reimar Wernich; Mæng, Michael

doi:10.1136/bmjdrc-2020-001803

Cited by 18 publications

(23 citation statements)

References 39 publications

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“…In a cohort study of patients in Denmark undergoing coronary angiography, those with diabetes but not CAD had an increased risk of PAD (HR,1.73 [95% CI, 1.51–1.97]) and lower limb revascularization (HR, 1.73 [95% CI, 1.51–1.97]) compared with those with neither diabetes nor CAD. 116 Patients with both diabetes and CAD also had an increased risk of PAD (HR, 3.90 [95% CI, 3.55–4.28]) and lower limb revascularization (HR, 4.61 [95% CI, 3.85–5.52]). 116…”

Section: Complicationsmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,450

2,336

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Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). Methods: The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2022 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population and an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, and the global burden of cardiovascular disease and healthy life expectancy. Results: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. Conclusions: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Section: Complicationsmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,450

2,336

View full text Add to dashboard Cite

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“…A cohort study in Japan showed that CAD was associated with 2.5-fold and 1.8-fold higher risk of PAD and amputation, respectively, among patients without diabetes, and associated with 3.9-fold and 9.5-fold higher risk of PAD and lower limb amputation among patients with diabetes. 35 In the retrospective study of Nishijima revealed the prevalence of CAD was significantly higher in the major than non-major amputation group (82% versus 63%, p = 0.04). It also appeared that the risk of CAD was correlated with the severity of limb ischemia.…”

Section: Discussionmentioning

confidence: 92%

Risk Factors for Major Amputation in Diabetic Foot Ulcer Patients

Qu¹,

Wang²,

Wei³

et al. 2021

DMSO

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Abstarct Background The purpose of our study was to identify the new and the more specific risk factors for major amputation in patients with diabetic foot ulcer (DFU). Methods We used data from the Electronic Medical Record (EMR) database of our hospital from February 2014 to July 2020. Patients with DFU and amputation were included in the study. The logistic regression model was adjusted for demographic characteristics and related comorbidities between major and minor amputation groups. Results Among 3654 patients with DFU, 363 (9.9%) were amputated. Patients with major versus minor amputation, in multivariable logistic regression models, major amputation independent factors included previous amputation history (odds ratio [OR] 2.31 [95% CI 1.17–4.53], p = 0.02), smoking (2.58 [1.31–5.07], p = 0.01), coronary artery disease (CAD) (2.67 [1.35–5.29], p = 0.03), ankle brachial index (ABI) <0.4 (15.77 [7.51–33.13], p < 0.01), Wagner 5 (5.50 [1.89–16.01], p < 0.01), activated partial thromboplastin time (APTT) (1.23 [1.03–1.48], p = 0.01), glycosylated hemoglobin A1c (HbA1c) (1.23 [1.03–1.48], p = 0.03), hemoglobin (Hb) (0.98 [0.96–1.00], p = 0.01), plasma albumin (ALB) (0.88 [0.81–0.95], p < 0.01) and white blood cell (WBC) (1.10 [1.04–1.16], p < 0.01). Conclusion Major amputation was associated with previous amputation history, smoking, CAD, Wagner 5, ABI <0.4, HbA1c, Hb, ALB, WBC, and APTT might be a new independent factor. In view of these factors, early prevention and guidance promptly orientated by multidisciplinary is of great significance to reduce the disability rate and economic burden.

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“…Incubation with 5 or 10 μg/ml berberine significantly inhibited AGE formation in high-glucose-AGEs-induced micro-endothelial injuries ( Hao et al, 2011 ). Diabetic peripheral neuropathy, characterized by perivascular neuropathy, is reported to be involved in vascular disorders associated with diabetes ( Olesen et al, 2021 ). The mesenteric artery, a part of the splanchnic circulation system, is involved in the regulation of arterial pressure ( van Dijk et al, 2020 ).…”

Section: Effects Of Berberine On Vascular Diseasesmentioning

confidence: 99%

Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases

Peng

et al. 2021

Front. Pharmacol.

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Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular diseases affecting vasculature in the heart, cerebrovascular disease, atherosclerosis, and diabetic complications have compromised quality of life for affected individuals and increase the burden on health care services. Berberine, a naturally occurring isoquinoline alkaloid form Rhizoma coptidis, is widely used in China as a folk medicine for its antibacterial and anti-inflammatory properties. Promisingly, an increasing number of studies have identified several cellular and molecular targets for berberine, indicating its potential as an alternative therapeutic strategy for vascular diseases, as well as providing novel evidence that supports the therapeutic potential of berberine to combat vascular diseases. The purpose of this review is to comprehensively and systematically describe the evidence for berberine as a therapeutic agent in vascular diseases, including its pharmacological effects, molecular mechanisms, and pharmacokinetics. According to data published so far, berberine shows remarkable anti-inflammatory, antioxidant, antiapoptotic, and antiautophagic activity via the regulation of multiple signaling pathways, including AMP-activated protein kinase (AMPK), nuclear factor κB (NF-κB), mitogen-activated protein kinase silent information regulator 1 (SIRT-1), hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), janus kinase 2 (JAK-2), Ca2+ channels, and endoplasmic reticulum stress. Moreover, we discuss the existing limitations of berberine in the treatment of vascular diseases, and give corresponding measures. In addition, we propose some research perspectives and challenges, and provide a solid evidence base from which further studies can excavate novel effective drugs from Chinese medicine monomers.

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Peripheral artery disease, lower limb revascularization, and amputation in diabetes patients with and without coronary artery disease: a cohort study from the Western Denmark Heart Registry

Cited by 18 publications

References 39 publications

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Risk Factors for Major Amputation in Diabetic Foot Ulcer Patients

Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases

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