Peripheral Arterial Tone Technology to Assess Endothelial Function in Pregnancy: PP.3.128

Carty, DM; Brennand, Janet; Delles, Christian; Dominiczak, AF

doi:10.1097/01.hjh.0000378452.77294.6b

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“…While the validity of AIx measured from PAT in adults is still being established, PAT-AIx has been shown to correlate with AIx derived from tonometric pressure waves in children 41 and pregnant women. 42 Moreover, our finding of an increased AIx following atenolol therapy is consistent with numerous studies noting similar increases in AIx derived from pressure waves. 18 -22 This would suggest that change in AIx detected following antihypertensive therapy with PAT accurately reflects change in AIx previously established with other reputed techniques.…”

Section: Study Limitationssupporting

confidence: 92%

Effect of Atenolol vs Metoprolol Succinate on Vascular Function in Patients With Hypertension

Heffernan

Suryadevara

Patvardhan

et al. 2011

Clinical Cardiology

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Background:We evaluated the effect of atenolol vs metoprolol succinate on vascular function in patients with essential hypertension. Hypothesis: Given intrinsic differences between these agents, we hypothesized that atenolol and metoprolol succinate would have disparate effects on vascular function. Methods: This study included 24 patients with hypertension (age 56 ± 2 years, 8 female, body mass index 28 ± 1) and featured a randomized, double-blind, crossover design. Each β-blocker (atenolol or metoprolol succinate) was taken by patients once daily for a 4-week period. Measures of vascular function included peripheral augmentation index (AIx) and pulse wave amplitude reactive hyperemia index from peripheral arterial tonometry, and brachial artery flow-mediated dilation from ultrasound. Results: There were similar reductions in mean arterial pressure following treatment with atenolol and metoprolol succinate. Compared with metoprolol succinate, there was a significant increase in peripheral AIx following atenolol therapy (P < 0.05). There were no changes in brachial artery flow-mediated dilation or pulse wave amplitude reactive hyperemia index following either drug treatment. Conclusions: Although atenolol and metoprolol succinate have similar effects on blood-pressure reduction, they have different effects on vascular function. Compared with metoprolol succinate, atenolol increases peripheral AIx. Neither drug has an effect on vascular endothelial function. These findings may have clinical implications, depending on the indication for treatment in an individual patient.

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Section: Study Limitationssupporting

confidence: 92%