Peripheral arterial disease is associated with higher mortality in patients with incident acute myocardial infarction

Abstract

AMI patients with PAD differ considerably from their counterparts without PAD in terms of long-term survival.

Peripheral artery disease and outcomes in patients with acute myocardial infarction

“…Furthermore, their adjustment model included race, self-reported history of PAD, inflammatory biomarkers, glycaemic control and health behaviours. Various other studies confirm the increased mortality seen in our study: a follow-up study by Dinser et al 15 investigating 4307 patients with incident acute myocardial infarction (AMI) found the mortality HR (follow-up 5.7 years) to be 1.70 (95% CI 1.35 to 2.13) in the PAD population. Moreover, a study consisting of 4480 patients hospitalised for AMI by Spencer et al 5 found a 1-year mortality OR of 2.00 (95% CI 1.58 to 2.52).…”

Outcome after percutaneous coronary intervention with contemporary stents in patients with concomitant peripheral arterial disease: A patient-level pooled analysis of four randomized trials

“…The present study assessed the outcome of treatment with contemporary DES and corroborates most findings of previous studies with bare metal or (mainly) early-generation DES. PAD patients, treated with bare metal coronary stents, showed higher rates of short and long-term mortality [4,5,8,11,23,24], which was also found in a pooled analysis of eight randomized PCI studies with bare metal stents [9].…”

Effect of transplantation of cardiac stem cells overexpressing integrin‑linked kinase on cardiac function of rats with acute myocardial infarction

“…Zhong and Rao ( 18 ) studied and showed that after the treatment of ischemic cardiomyopathy with CSC transplantation therapy, the migration and proliferation capabilities of CSCs are superior, there are many new cells and blood vessels in the MI region, and cardiac function recovery is better. ILK can regulate intracellular signaling pathways and transmit extracellular signals into cells, thereby promoting cell survival, reducing apoptosis and promoting cell proliferation and differentiation ( 3 , 19 , 20 ).…”

“…The traditional treatment methods of MI include drug therapy, interventional therapy and coronary artery bypass grafting. However, these treatment methods bring different degrees of physical or psychological burden to patients due to poor efficacy or complications ( 3 – 6 ). Poulos ( 7 )studied and showed that stem cell transplantation can promote the regeneration of myocardial cells in the local infarct region, thereby repairing the heart and improving the cardiac function.…”