Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats

Schreiber, Anne Karoline; Neufeld, Manuele; Jesus, Carlos Henrique Alves; Cunha, Joice Maria da

doi:10.1016/j.neuropharm.2012.08.009

Cited by 28 publications

(20 citation statements)

References 75 publications

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“…In mammals, the effects of cannabinoid substances in antinociception are also mediated by the activation of CB1 receptors in specific nociception-related central structures, which activates descending nociception control pathways [5]. In rodent models of acute nociception, cannabinoids acting via CB1 receptors, inhibit responses to noxious thermal [22] and mechanical [23] stimuli, as well as the nociceptive response to the formalin test [24][25][26]. This is the first evidence of the involvement of cannabinoid system in modulation of antinociception in fish.…”

Section: Discussionmentioning

confidence: 72%

Acute administration of a cannabinoid CB1 receptor antagonist impairs stress-induced antinociception in fish

Wolkers

Barbosa

Menescal-de-Oliveira

et al. 2015

Physiology & Behavior

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Section: Discussionmentioning

confidence: 72%

Acute administration of a cannabinoid CB1 receptor antagonist impairs stress-induced antinociception in fish

Wolkers

Barbosa

Menescal-de-Oliveira

et al. 2015

Physiology & Behavior

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“…Exogenous administration locally in the paw skin of both AEA and 2-AG in rats with partial sciatic nerve ligation (PNL)- or diabetes-induced neuropathic pain and intrathecally into the spinal cord of rats with CCI-induced neuropathic pain have produced antihyperalgesic activities (Guindon and Beaulieu, 2006; Desroches et al, 2008; Schreiber et al, 2012; Starowicz et al, 2012; Desroches et al, 2014). In the current study, systemic administration (i.p.)…”

Section: Discussionmentioning

confidence: 99%

“…AEA has been reported to produce its antinociceptive effects via activation of both CB1 and CB2 receptors (Schreiber et al, 2012). However, other studies have shown that AEA produces its antinociceptive effects via activation of CB1 receptors but not CB2 receptors (Calignano et al, 1998; Guindon and Beaulieu, 2006).…”

Section: Discussionmentioning

confidence: 99%

Antihyperalgesic Activities of Endocannabinoids in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

2017

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Background: Nucleoside reverse transcriptase inhibitors (NRTIs) are the cornerstone of the antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). However, their use is sometimes limited by the development of a painful sensory neuropathy, which does not respond well to drugs. Smoked cannabis has been reported in clinical trials to have efficacy in relieving painful HIV-associated sensory neuropathy.Objectives: The aim of this study was to evaluate whether the expression of endocannabinoid system molecules is altered during NRTI-induced painful neuropathy, and also whether endocannabinoids can attenuate NRTI-induced painful neuropathy.Methods: BALB/c mice were treated with 25 mg/kg of 2′,3′-dideoxycytidine (ddC, zalcitabine), a NRTI, to induce thermal hyperalgesia. The expression of endocannabinoid system molecules was evaluated by real time polymerase chain reaction in the brain, spinal cord and paw skin at 6 days post ddC administration, a time point when mice had developed thermal hyperalgesia. The effects of the endocannabinoids, N-arachidonoyl ethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG), the cannabinoid type 1 (CB1) receptor antagonist AM 251, CB2 receptor antagonist AM 630, and G protein-coupled receptor 55 (GPR55) antagonists ML193 and CID 16020046 on ddC-induced thermal hyperalgesia were evaluated using the hot plate test.Results: ddC treatment resulted in thermal hyperalgesia and increased transcripts of the synthesizing enzyme Plcβ1 and decreased Daglβ in the paw skins, but not Napepld, and Daglα compared to vehicle treatment. Transcripts of the inactivating enzymes Faah and Mgll were downregulated in the brain and/or paw skin but not in the spinal cord of ddC-treated mice. Both AEA and 2-AG had antihyperalgesic effects in mice with ddC-induced thermal hyperalgesia, but had no effect in ddC-naïve mice. The antihyperalgesic activity of AEA was antagonized by AM251 and AM630, whereas the activity of 2-AG was antagonized by AM251, ML193 and CID 16020046, but not by AM630.Conclusion: These data show that ddC induces thermal hyperalgesia, which is associated with dysregulation of the mRNA expression of some endocannabinoid system molecules. The endocannabinoids AEA and 2-AG have antihyperalgesic activity, which is dependent on cannabinoid receptor and GPR55 activation. Thus, agonists of cannabinoid receptors and GPR55 could be useful therapeutic agents for the management of NRTI-induced painful sensory neuropathy.

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“…Many studies have shown that the antinociceptive activity of various drugs is attenuated by cannabinoid (Gühring et al, 2002;Guindon et al, 2006;Malan et al, 2001;Schreiber et al, 2012) or opioid (Lembeck and Donnerer, 1985;Hong and Abbott, 1995;Zhao et al, 2003) receptor antagonists. Regarding the receptor subtypes involved, there is evidence for the involvement of both CB1 and CB2 and various opioid receptors.…”

Section: Discussionmentioning

confidence: 99%

Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms

Godin

Araújo

César

et al. 2015

European Journal of Pharmacology

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Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats

Cited by 28 publications

References 75 publications

Acute administration of a cannabinoid CB1 receptor antagonist impairs stress-induced antinociception in fish

Acute administration of a cannabinoid CB1 receptor antagonist impairs stress-induced antinociception in fish

Antihyperalgesic Activities of Endocannabinoids in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms

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