Peripheral and cranial nerve sheath tumors

Abstract

Peripheral nerve tumors are classified according to the specific features of cellular differentiation. The most common types include schwannoma and neurofibroma. These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis. The majority of peripheral nerve tumors are benign but malignant transformation does occur. Metastatic tumors can also affect peripheral nerves. The diagnostic modality of choice is magnetic resonance imaging. Positron emission tomography is a useful technique in the presurgical differentiation between benign and malignant peripheral nerve sheath tumors. Treatment is directed towards symptomatic control. Surgery, radiation and, in rare instances, chemotherapy are the major treatment modalities employed.

Overexpression of CXCL16 and its receptor CXCR6/Bonzo promotes growth of human schwannomas

“…Synonyms include neurilemmomas and neurinomas (Burger and Scheithauer, 1994;Scheithauer et al, 1997). These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis (NF) types 1 and 2 or schwannomatosis (Halliday et al, 1991;Mrugala et al, 2005). The etiology of schwannomas is thought to be related to alteration or loss of the NF2 gene product of chromosome 22 (also designed Merlin) a presumed tumor suppressor gene (Ferner and O'Doherty, 2002;Hanemann et al, 2006;Utermark et al, 2005).…”

Neurofibroma del hipogloso en un niño colombiano. Reporte de caso

“…En general, los neurofibromas son lesiones focales, bien definidas, de crecimiento lento, no encapsuladas y que comprometen las raíces, los troncos o los plexos nerviosos (13). En la cavidad oral, la mayoría de tumores se asocian con neurofibromatosis; sin embargo, algunos casos esporádicos se han reportado en lengua, mucosa oral, labios, paladar, glándula parótida y hueso mandibular, sin mencionar el nervio de procedencia (10).…”

Metastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review

“…6 In a case series of 54 patients with MPNST, the clinical features associated with a more favorable prognosis included: younger age, tumor resectability, and tumor size less than 5 cm. 7 Tumor biology. The chromosomal abnormality associated with von Recklinghausens neurofibromatosis (NF1 gene) has been mapped to a small locus on 17q.…”