Peripheral and central aggressive form of Pindborg tumor of mandible – A rare case report

Vinayakrishna, K.; Soumithran, C.S.; Sobhana, C.R.; Biradar, Vijay

doi:10.1016/j.jobcr.2013.07.001

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…Odontogenic benign neoplasms and cysts display diverse biological behaviors, extending from indolent encapsulated lesions to highly aggressive infiltrating and recurring lesions (3) . A CEOT, known as Pindborg's tumor, commonly shows high aggressiveness and rapid progression over a short duration despite its benign behavior (24) . A CEOT is similar to a conventional AB as they are benign epithelial odontogenic neoplasms with local invasiveness, although a conventional AB is the most aggressive odontogenic lesion with the highest tendency for recurrence (25) .…”

Section: Discussionmentioning

confidence: 99%

Double Immunohistochemical Analysis of PCNA and FAK Expression in Selected Odontogenic Lesions

Baz

Mohamed

2023

Egyptian Dental Journal

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Background: Odontogenic neoplasms and cysts have diverse biological behaviors, ranging from indolence to aggression along a spectrum. The proliferating cell nuclear antigen (PCNA) is an antigen involved in DNA synthesis and proliferation. Focal adhesion kinase (FAK) is a cytoplasmic molecule associated with cellular signaling, growth, and invasion. PCNA and FAK markers have been shown to be involved in neoplastic proliferation, invasion, and migration. Hence, an immunohistochemical assay of PCNA and FAK can be used as a predictive tool for the level of aggressive behavior of odontogenic lesions. Methods:The current study was conducted to evaluate the expressions of PCNA and FAK. A double immunohistochemical technique for conventional ameloblastoma (AB), unicystic AB, calcifying epithelial odontogenic tumor (CEOT), and glandular odontogenic cyst (GOC) was used to evaluate the role of both markers in assessments of the aggressiveness of selected odontogenic lesions. All formalin-fixed paraffin-embedded blocks (n = 10) for each studied group were double PCNA and FAK immunostained and then assessed using a transmission light microscope and an image-analyzer computer system. Statistical analysis was performed with a one-way analysis of variance (ANOVA) test followed by Tukey's post hoc test.Results: All study groups showed nuclear immunoreactivity of PCNA and cytoplasmic immunoreactivity for FAK. The greatest mean nuclear count of PCNA and the greatest mean area percent for FAK were both recorded in the aggressive lesions; i.e., the CEOT group and conventional AB group. The non-aggressive unicystic AB group had a lower mean nuclear count for PCNA and showed the lowest mean area percent for FAK. Conclusions:In conclusion, PCNA and FAK immunoexpression profiles may have a strong correlation with the aggressive nature of AB, CEOT, and GOC. Hence, PCNA and FAK markers could aid in their routine examination, treatment planning, and prognosis.

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Section: Discussionmentioning

confidence: 99%

Double Immunohistochemical Analysis of PCNA and FAK Expression in Selected Odontogenic Lesions

Baz

Mohamed

2023

Egyptian Dental Journal

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“…Furthermore, involvement of the maxilla or the maxillary sinus is associated with rapid growth and invasion of the orbits and skull base [27]. Intraosseous involvement is another feature that is associated with higher chance of recurrence as compared to extraosseous tumor [27, 33]. In contrast, the presence of calcification and amyloid-like material indicates more differentiation and a lower likelihood of recurrence [34].…”

Section: Discussionmentioning

confidence: 99%

“…Tumors larger than 4 cm are treated by radical resection followed by reconstruction. Since there is high risk of recurrence if the tumor is incompletely resected, long-term follow up for at least 5 years is recommended [27, 33].…”

Section: Discussionmentioning

confidence: 99%

Calcifying Epithelial Odontogenic (Pindborg) Tumor in a Child: A Case Report and Literature Review

Fazeli

Giglou

Soliman

et al. 2019

Head and Neck Pathol

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Calcifying epithelial odontogenic tumor (CEOT) is a rare neoplasm, which accounts for < 1% of all odontogenic tumors. CEOT occurs more frequently in adults with a peak incidence in the 5th decade of life and is extremely rare in the pediatric population. We present a case of a 13-year-old girl who was found to have a mandibular CEOT. We summarize the radiological features, pathological findings, clinical management and literature review focusing on this entity in children.Electronic supplementary materialThe online version of this article (10.1007/s12105-019-01009-1) contains supplementary material, which is available to authorized users.

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Pediatric Odontogenic Cysts and Tumors

Moles,

Magraw

2024

Oral and Maxillofacial Surgery Clinics of North America

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Peripheral and central aggressive form of Pindborg tumor of mandible – A rare case report

Cited by 10 publications

References 10 publications

Double Immunohistochemical Analysis of PCNA and FAK Expression in Selected Odontogenic Lesions

Double Immunohistochemical Analysis of PCNA and FAK Expression in Selected Odontogenic Lesions

Calcifying Epithelial Odontogenic (Pindborg) Tumor in a Child: A Case Report and Literature Review

Pediatric Odontogenic Cysts and Tumors

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