Peripheral and central administration of T3 improved the histological changes, memory and the dentate gyrus electrophysiological activity in an animal model of Alzheimer’s disease

Farbood, Yaghoob; Sarkaki, Alireza; Mard, Seyyed Ali; Ahangarpour, Akram; Khorsandi, Layasadat

doi:10.1007/s11011-016-9947-2

Cited by 20 publications

(12 citation statements)

References 54 publications

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Section: Discussionmentioning

confidence: 99%

“…Moreover, another study reported that hypofunction of the adenohypophysis due to circadian rhythm disturbances in AD decreased TSH levels ( 34 ). Although it is not elusive whether thyroid dysregulation occurs before or after the onset of AD, treatment with thyroid hormone restoration has been reported to potentially improve cognitive deficits in animal studies ( 35 – 37 ). We performed an additional analysis excluding individuals who were diagnosed with thyroid disease 2 years before the index date to compensate for the characteristics of this study, which had a case-control design ( Table S4 ).…”

Section: Discussionmentioning

confidence: 99%

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The Association Between Thyroid Diseases and Alzheimer’s Disease in a National Health Screening Cohort in Korea

et al. 2022

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ObjectivesThyroid dysfunction is linked to an increased risk of cognitive impairment. However, studies on the relationships between thyroid diseases and Alzheimer’s disease (AD) have reported conflicting results. We investigated the associations between several thyroid diseases and AD in a nested case-control study.MethodsA total of 1,977 participants with AD were identified by claims data from 2002-2015 among a random sample of half a million people in the Korean National Health Insurance database. We recruited 16,473 age- and sex-matched (1:4 ratio) control participants and applied conditional logistic regression to estimate the relationships between thyroid diseases and AD, with adjustments for potential confounders, such as basic demographics, lifestyle factors, and various medical conditions or comorbidities.ResultsThe prevalence rates of hypothyroidism (odds ratio [OR]=1.14, 95% confidence interval [CI]=1.00-1.30), thyroiditis (OR=1.22, 95% CI=1.05-1.40), and hyperthyroidism (OR=1.13, 95% CI=1.01-1.28) were significantly higher in participants with AD than in control participants after adjustment for confounders.ConclusionIn this large national sample, we found significant relationships between several thyroid diseases and AD. Despite of the need for further investigation, these findings could better support to appreciate the pathophysiology of AD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Association Between Thyroid Diseases and Alzheimer’s Disease in a National Health Screening Cohort in Korea

et al. 2022

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“…Although this work is very relevant, the mechanisms by which the decreased serum free T3 levels increase the risk of developing this neurodegenerative disease have not been elucidated. Moreover, peripheral and central administration of T3 improved memory de cits in AD animal models (Farbood et al 2017). However, the clinical signi cance of those ndings remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer’s Disease

et al. 2022

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Introduction: Alzheimer disease's (AD) is a neurodegenerative disorder and it is known that the central nervous system (CNS) is an important target of thyroid hormones (TH). Moreover, an inverse association between serum triiodothyronine (T3) levels and the risk of AD was reported.Aim: To evaluate the effects of T3 treatment on the depression-like behavior observed in male transgenic 3xTg-AD mice. Main methods: Animals were divided into 2 groups, one group received daily intraperitoneal injections of L-T3 (T3 group), and the other received an equivalent volume of 0.9% saline (Control group). The experimental protocol lasted 21 days, and behavioral tests were conducted on days 15-19. At the conclusion of the experiment, the TH pro le and hippocampal gene expression were evaluated.Key ndings: It was observed that the T3-treated group presented signi cantly increased serum T3 and decreased thyroxine (T4) levels. When compared to control hippocampal samples, the T3 group exhibited attenuated glycogen synthase kinase-3 (GSK3), metalloproteinase 10 (ADAM10), amyloid-beta precursorprotein (APP), serotonin transporter (SERT), 5HT1a receptor, monocarboxylate transporter 8 (MCT8) and bone morphogenetic protein 7 (BMP-7) gene expression levels and augmented superoxide dismutase 2 (SOD2) and Hairless gene expression levels. Additionally, T3-treated animals displayed reduced immobility time in both the tail suspension and forced swim tests, and in the latter presented a higher latency time when compared to the control group.Signi cance: Taken together, our results demonstrate that in an AD mouse model, T3 supplementation promotes improvements in depression-like behavior, likely through the modulation of the serotonergic pathway, and also attenuated disease progression.

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“…Whereas, hypothyroidism reduced hippocampal neurogenesis (10) and in CA1 neurons it impaired long-term potentiation (LTP), that was then restored by TH administration (11,12). Moreover, TH have been demonstrated to influence amyloid precursor protein (APP) transcription, the alternative splicing of APP mRNA, APP protein processing (13)(14)(15) and to rescue memory deficits in AD rodent models (16)(17)(18)(19). These results suggest that TH may exert a neuroprotective role against β-amyloid (Aβ)dependent neuronal impairment, which is assumed to be one of the pathophysiological mechanisms involved in AD.…”

Section: Introductionmentioning

confidence: 99%

Exogenous 3-Iodothyronamine Rescues the Entorhinal Cortex from β-Amyloid Toxicity

Accorroni

Rutigliano

Sabatini

et al. 2020

Thyroid

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Background. A novel branch of thyroid hormone (TH) signaling is represented by 3iodothyronamine (T 1 AM), an endogenous TH derivative that interacts with specific molecular targets, including trace amine associated receptor-1 (TAAR 1 ), and induces pro-learning and antiamnestic effects in mice. Dysregulation of TH signaling has long been hypothesized to play a role in Alzheimer's disease (AD). In the present investigation, we explored the neuroprotective role of T 1 AM in beta amyloid (Aβ)-induced synaptic and behavioral impairment, focusing our study on the entorhinal cortex (EC), an area which is early affected by AD pathology.Methods. Field potentials were evoked in EC layer II and long-term potentiation (LTP) was elicited by high frequency stimulation (HFS). T 1 AM (5 µM) and/or Aβ 142 (200 nM), were administered for 10 minutes, starting 5 minutes before HFS. Selective TAAR 1 agonist RO5166017 (250 nM) and TAAR 1 antagonist EPPTB (5 nM) were also used. The electrophysiological experiments were repeated in EC-slices taken from a mouse model of AD (mhAPP, J20 line). We also assessed the in vivo effects of T 1 AM on EC-dependent associative memory deficits, that were detected in mhAPP mice by behavioral evaluations based on the novel-object recognition paradigm. TAAR 1 expression was determined by Western blot, while T 1 AM and its metabolite 3-iodothyroacetic acid (TA 1

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Peripheral and central administration of T3 improved the histological changes, memory and the dentate gyrus electrophysiological activity in an animal model of Alzheimer’s disease

Cited by 20 publications

References 54 publications

The Association Between Thyroid Diseases and Alzheimer’s Disease in a National Health Screening Cohort in Korea

The Association Between Thyroid Diseases and Alzheimer’s Disease in a National Health Screening Cohort in Korea

Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer’s Disease

Exogenous 3-Iodothyronamine Rescues the Entorhinal Cortex from β-Amyloid Toxicity

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