Peripheral airway function at 12 months post allogeneic haematopoietic stem cell transplantation (allo-HSCT)

Multiple breath washout and oscillometry after allogenic HSCT: a scoping review

“…Follow-up post-HSCT ranged from 1 month to 20 years, with only 6/17 (35%) including baseline measurement. Furthermore, while all MBW tests of the adult population were performed using N 2 [ 45 , 48 – 50 ], among the paediatric population this was evenly distributed between N 2 [ 42 , 43 , 46 , 54 ] and SF 6 [ 47 , 55 – 57 ], with the inert gas not specified in the case report [ 58 ]. Clinical stability at time of testing was required in 6/17 studies (35%) [ 42 , 44 , 47 , 48 , 51 , 53 ], but unclear in the remainder of studies.…”

“…Only 9/17 studies (53%) had a published manuscript available [ 42 – 44 , 46 , 48 , 53 , 55 , 57 , 58 ], with the remaining eight being described in conference abstracts. Sex distribution was available for 12/17 cohorts (71%) [ 42 – 44 , 46 – 48 , 50 , 52 , 54 , 55 , 57 , 58 ]. Age at HSCT or at time of PFT was available for all but 4/17 cohorts [ 45 , 49 , 51 , 53 ].…”

“…In one study, pulmonary cGVHD diagnosis was defined based on respiratory signs or symptoms and compatible computed tomography scan in the absence of an alternative cause [ 46 ]. Reference equations used to obtain percent predicted spirometry values, if obtained, were often not stated [ 45 , 50 , 52 , 54 , 55 , 58 – 60 ] and varied among the remaining studies. Four of 17 [ 43 , 44 , 46 , 57 ] used Global Lung Function Initiative (GLI) equations [ 61 ], one [ 42 ] used all-age reference equations, which were the precursor to GLI equations [ 62 ], and one [ 48 ] used European Coal and Steel Community equations [ 63 ].…”

“…Sex distribution was available for 12/17 cohorts (71%) [ 42 – 44 , 46 – 48 , 50 , 52 , 54 , 55 , 57 , 58 ].…”

“…Only four studies clearly described baseline MBW data within their cohorts [ 50 , 56 , 57 , 59 ]. In one paediatric cohort (n=62), mean SF 6 -based LCI was within the normal range [ 56 ].…”