Peripheral actions of tachykinins

Lecci, Alessandro; Giuliani, Sandro; Tramontana, Manuela; Carini, F; Maggi, Carlo Alberto

doi:10.1054/npep.2000.0825

Cited by 70 publications

(41 citation statements)

References 95 publications

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“…Their biological actions are mediated through three receptors belonging to the family of G protein-coupled receptors (GPCR), denoted NK 1 , NK 2 and NK 3 , that have highest affinity for SP, NKA and NKB, respectively (Henry, 1986;Regoli et al, 1994a, b;Lecci et al, 2000). SP and NKA, but not NKB, are present within capsaicinsensitive sensory nerves in the periphery and are locally released by a number of physical and chemical stimuli (Holzer, 1988;Maggi & Meli, 1988).…”

Section: Introductionmentioning

confidence: 99%

Tachykinins and tachykinin receptors in human uterus

Patak

Candenas

Pennefather

et al. 2003

British J Pharmacology

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1 Studies were undertaken to determine the nature of the receptors mediating contractile effects of tachykinins in the uteri of nonpregnant women, and to analyse the expression of preprotachykinins (PPT), tachykinin receptors and the cell-surface peptidase, neprilysin (NEP), in the myometrium from pregnant and nonpregnant women. 2 The neurokinin B (NKB) precursor PPT-B was expressed in higher levels in the myometrium from nonpregnant than from pregnant women. Faint expression of PPT-A mRNA was detectable in the myometrium from nonpregnant but not pregnant women. PPT-C, the gene encoding the novel tachykinin peptide hemokinin-1 (HK-1), was present in trace amounts in the uteri from both pregnant and nonpregnant women. 3 Tachykinin NK 2 receptors were more strongly expressed in tissues from nonpregnant than from pregnant women. NK 1 receptor mRNA was present in low levels in tissues from both pregnant and nonpregnant women. A low abundance transcript corresponding to the NK 3 receptor was present only in tissues from nonpregnant women. 4 The mRNA expression of the tachykinin-degrading enzyme NEP was lower in tissues from nonpregnant than from pregnant women. 5 Substance P (SP), neurokinin A (NKA) and NKB, in the presence of the peptidase inhibitors thiorphan, captopril and bestatin, produced contractions of myometrium from nonpregnant women. The order of potency was NKAbSPXNKB. The potency of NKA was unchanged in the absence of peptidase inhibitors. Nle 10 ]NKA(4 -10). 8 These data are consistent with a role of tachykinins in the regulation of human uterine function, and reinforce the importance of NK 2 receptors in the regulation of myometrial contraction.

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Section: Introductionmentioning

confidence: 99%

Tachykinins and tachykinin receptors in human uterus

Patak

Candenas

Pennefather

et al. 2003

British J Pharmacology

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“…Tachykinins (substance P, neurokinin A (NKA), and neurokinin B) act as neurotransmitters in the enteric nervous system (14,15), spinal cord, and brain (16 -18). They exhibit preferential binding to three receptor subtypes, NK1, NK2, and NK3, respectively.…”

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confidence: 99%

The Neurokinin A Receptor Activates Calcium and cAMP Responses through Distinct Conformational States

Palanché¹,

Ilien²,

Zoffmann³

et al. 2001

Journal of Biological Chemistry

121

119

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“…Numerous neuropeptides were depicted, principally, tackykinin and opioid related peptides [Felippotti et al, 2012;Ferland et al, 2011;Mika et al, 2011;Bali et al, 2014]. Members of the tachykinin family are generally pronociceptive neuropeptides and have been known to play an important role in central sensitization leading to hyperalgesia and allodynia [Lecci et al, 2000]. Opioid peptides (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Many members of the tachykinin family (e.g. Substance P) are mostly pro-nociceptive neuropeptides and have been known to play an essential role in central sensitization leading to hyperalgesia and allodynia [Lecci et al, 2000]. Opioid peptides (i.e.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography-electrospray linear ion trap mass spectrometry analysis of targeted neuropeptides in Tac1−/− mouse spinal cords reveals significant lower concentration of opioid peptides

Saidi

Beaudry

2015

Neuropeptides

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Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in humans. Recent investigations suggest that both pronociceptive tachykinins and the analgesic opioid systems are important for normal pain sensation. The analysis of opioid peptides in Tac1 -/-spinal cord tissues offers a great opportunity to verify the influence of the tachykinin system on specific opioid peptides. The objectives of this study were to develop a HPLC-MS/MRM assay to quantify targeted peptides in spinal cord tissues. Secondly, we wanted to verify if the Tac1 -/-mouse endogenous opioid system is hampered and therefore affect significantly the pain modulatory pathways. Targeted neuropeptides were analyzed by high performance liquid chromatography linear ion trap mass spectrometry. Our results reveal that EM-2, Leu-Enk and Dyn A were down-regulated in Tac1 -/-spinal cord tissues. Interestingly, Dyn A was almost 3 fold down-regulated (p < 0.0001). No significant concentration differences were observed in mouse Tac1 -/-spinal cords for Met-Enk and CGRP. The analysis of Tac1 -/-mouse spinal cords revealed noteworthy decreases of EM-2, Leu-Enk and Dyn A concentrations which strongly suggest a significant impact on the endogenous pain-relieving mechanisms. These observations may have insightful impact on future analgesic drug developments and therapeutic strategies.3

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Peripheral actions of tachykinins

Cited by 70 publications

References 95 publications

Tachykinins and tachykinin receptors in human uterus

Tachykinins and tachykinin receptors in human uterus

The Neurokinin A Receptor Activates Calcium and cAMP Responses through Distinct Conformational States

Liquid chromatography-electrospray linear ion trap mass spectrometry analysis of targeted neuropeptides in Tac1−/− mouse spinal cords reveals significant lower concentration of opioid peptides

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