Peripher autonome Potentiale: Norm werte unter verschiedenen Bedingungen

Schwalen, S.; Jörg, Johannes

doi:10.1055/s-2008-1060295

Cited by 5 publications

(16 citation statements)

References 5 publications

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“…We found the corresponding parameters in our control group in accordance with the literature [10]. As described in previous studies, we noticed higher amplitudes and longer latencies of the SSR after forced inspiration in comparison with electrical stimulation in the control group as well as in groups on medication.…”

Section: Discussionsupporting

confidence: 93%

Neurophysiologic Tests during Antidepressive Treatment - an Exploratory Study

Sattler

Richter²,

Fritzsche³

et al. 2000

Pharmacopsychiatry

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This is a non-randomized exploratory study showing the sensitivity of neurophysiological parameters for autonomic side-effects during the application of antidepressant drugs. Inpatients on tricyclic antidepressants (TCA: amitriptyline or doxepine), inpatients on serotonine-reuptake inhibitors (SSRI: fluvoxamine or paroxetin) and a control group of healthy volunteers underwent neurophysiological examination. The treatment group was investigated after at least 7 days of continuous treatment with the final dose. Adjustment of the autonomic nervous system was studied, first, by measuring latency and amplitude of the sympathetic skin response (SSR), elicited by electric stimuli and by deep inspiration, and second, by analysis of the heart rate variation (HRV) during rest and inspiration. Relevant affections of the peripheral parts of the reflex arc under discussion were excluded by taking the nerve conduction velocity (NCV) and F-wave referring to cervical segment C7. In total, 48 individuals were examined. The TCA group showed delayed latencies and smaller amplitudes of the SSR in comparison with the controls. In the SSRI group, these parameters did not differ significantly from those of the controls. Analysis of HRV put further emphasis on the impaired adjustment of the autonomic nervous system in the TCA group. To sum up, our test battery indicated a specific vegetative alteration due to TCA.

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Section: Discussionsupporting

confidence: 93%

Neurophysiologic Tests during Antidepressive Treatment - an Exploratory Study

Sattler

Richter²,

Fritzsche³

et al. 2000

Pharmacopsychiatry

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“…10 19 We used our standard normal values as normal values for the SSR; pathological latencies were defined as latencies 3 SDs higher than those of normal people; pathological amplitudes were <260 µV at the hands and <240 µV at the feet. 18 A fall in systolic (diastolic) blood pressure of more than 20 (10) mm Hg on standing was considered to be abnormal. 20 …”

Section: Discussionmentioning

confidence: 99%

“…18 Briefly, standard disc electrodes (10 mm) were attached to the palms and soles as active electrodes and to the dorsum of the hands and feet as reference electrodes. An electromyograph (Dantec; Medtronic GmbH, Düsseldorf, Germany) was used to create the stimulus and monitor the potentials.…”

Section: Ssr and Nerve Conduction Velocitymentioning

confidence: 99%

Autonomic nervous system function in Huntington's disease

Andrich

2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

101

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Objective: To investigate whether Huntington's disease (HD) affects autonomic nervous system (ANS) functioning. Methods: Twenty patients with HD who had positive genetic test results underwent standardised ANS function tests including sympathetic skin responses (SSRs) of the hands and feet, measurements of heart rate variability (HRV), both during five minutes of resting and deep respiration, and an orthostatic blood pressure test. Patients were classified according to the motor subscale of the unified Huntington's disease rating scale (UHDRS; mean (SD) score 26.4 (13.6)) and divided into two subgroups: UHDRS <25 points (early stages, E-HD) and UHDRS >25 points (mid stages, M-HD). Autonomic indices were compared with those obtained for a group of well matched healthy controls (n=60). Results: Overall, patients showed lower HRV indices than controls. Multivariate analysis with the independent factor of "group" (controls, E-HD, M-HD) showed a significant group effect on both the high frequency power (F=4.32, p=0.017) and the coefficient of variation (F=4.23, p=0.018), indicating a significant reduction in vagal modulation in the M-HD group. There was a shift in autonomic neurocardiac balance towards sympathetic predominance in the M-HD group compared with controls (F=2.89, p=0.062). Moreover, we found an inverse correlation between the severity of clinical HD symptoms (assessed by the UHDRS) and the modulation of cardiovagal activity (p=0.028). Vagal dysregulation was present in two patients; one of them also showed a pathological blood pressure test and a latency prolongation in the SSRs of the hands. Two other patients had pathologically reduced SSR amplitudes. Only patients of the M-HD group were affected. Conclusion: Autonomic dysfunction is present even in the middle stages of HD and affects both the sympathetic and parasympathetic branch of the ANS.

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“…Aus früheren Untersuchungen ist bekannt, dass unabhängig von der Art des Stimulationsmodus (akustisch vs. elektrisch) die Latenzen und Amplituden der SSR keine signifikanten Unterschiede aufwiesen [8,9,12,13]. Dabei wird der kombinierte Einsatz von verschiedenen Reizmodalitäten zur Objektivie- rung möglicher somatosensibler (afferenter) Schädigungen als günstig erachtet [7,9,12].…”

Section: Diskussionunclassified

“…Diese Untersuchungen konnten den Nachweis erbrin- gen, dass die SSR-Latenzen reproduzierbar und intraindividuell stabil waren [6 ± 13]. Ebenso wurde nachgewiesen, dass die SSR keine Abhängigkeit von Alter, Gröûe, Geschlecht sowie verschiedenen Reizmodalitäten aufwiesen [9,12,13]. Trotz der Vielzahl von Studien zur SSR gibt es in der Literatur keine systematischen Untersuchungen über Normwerte und Stabilität der Leitgeschwindigkeiten autonomer Fasern.…”

Section: Introductionunclassified

Untersuchung der Leitgeschwindigkeiten autonomer Nervenfasern mittels sympathischer Hautantwort

Willert¹,

Roder²,

Ohnesorge³

2001

Klin Neurophysiol

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Study: Autonomic nerve conduction velocity (ANCV) can be determined non-invasively using peripheral autonomic surface potentials of the skin. The sympathetic skin response (SSR) is a constituent of clinical diagnostics. Several authors have established standardised values for SSR on hands and feet. No systematic investigation of peripheral ANCV has been conducted. The examinations were performed on 30 healthy individuals. The following four points for the placement of leads were located on the upper body: vertebral column in dermatome T6, axilla, hand (palm), 3 rd finger. The points on the lower body were: vertebral column over dermatome T12, poplitea, foot (sole), hallux (plantar). Stimulation was performed as electrical single square. The ANCV was calculated as the quotient of the distance and the difference between two SSR latencies. To determine whether the ANCV depends on the temperature, the surface temperature of 10 participants was increased incrementally from 31 to 37 8C, measuring the SSR on poplitea, foot and hallux. In the T6 area, the SSR was not detectable in most of the participants. We have therefore not systematically calculated the ANCV in the section T6-axilla. The ANCV in the upper and lower extremities were approximately equal in the arm (1.63 0.45 m/s), thigh (1.74 0.42 m/s) and lower leg (1.56 0.46 m/s). In the distal areas of hand (0.38 0.16 m/s) and foot (0.36 0.14 m/s), the values were significantly lower. Increasing the skin temperature did not significantly change the SSR latency values or, correspondingly, the ANCV. This study indicates that ANCV derived from SSR can be reliably determined from healthy subjects.

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Peripher autonome Potentiale: Norm werte unter verschiedenen Bedingungen

Cited by 5 publications

References 5 publications

Neurophysiologic Tests during Antidepressive Treatment - an Exploratory Study

Neurophysiologic Tests during Antidepressive Treatment - an Exploratory Study

Autonomic nervous system function in Huntington's disease

Untersuchung der Leitgeschwindigkeiten autonomer Nervenfasern mittels sympathischer Hautantwort

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