Peripartum Management of Vonwildebrand Disease: A Case Report

Abstract

Understanding coagulation disorders is essential, especially for obstetricians and intensive care providers managing parturients, as these disorders can have significant consequences for the mother and child during the peripartum period. Von Willebrand-Jürgens syndrome or von Willebrand disease is the most common congenital bleeding disorder. It is subject to autosomal inheritance with variable penetrance and expressivity. The cause of the disease lies in quantitative (type 1, type 3) or qualitative (type 2) abnormalities of vonWillebrand factor (vWF). vWF has two important functions in coagulation. On the one hand, it circulates in plasma as a carrier protein for factor VIII and thus has a protective function; on the other hand, it is responsible for platelet adhesion to the subendothelium of injured vessels and platelet aggregation . The risk of bleeding varies according to the severity of the injury. The therapeutic management strategy depends on the type of disease. In this paper, we report the observation of two patients with von Willebrand disease who had vaginal deliveries.