Peripartum Cardiomyopathy and Stroke

Dyken, Mark Eric; Biller, José

doi:10.1159/000108502

Cited by 16 publications

(8 citation statements)

References 18 publications

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“…The cause and pathogenesis of PPCM remains unclear, although a number of aetiological factors have been proposed, including myocarditis,85 nutritional deficiency,86 abnormal immune response,87 stress-activated cytokines88 and viral antigen persistence 89. The presence of left ventricular thrombus is common in PPCM,88 and peripheral embolisation may occur, resulting in ischaemic bowel,90 myocardial infarction,91 acute limb ischaemia92 and cerebral infarction 7 93…”

Section: Specific Stroke Syndromes In Pregnancymentioning

confidence: 99%

Stroke in pregnancy and the puerperium

Treadwell

Thanvi

Robinson

2008

Postgraduate Medical Journal

134

114

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Stroke is a recognised complication of pregnancy, contributing to more than 12% of all maternal deaths. Estimated incidence rates vary considerably from 4.3 to 210 strokes per 100 000 deliveries. Atherosclerosis is rare in young adults, and so other causes of stroke become increasingly likely. Aetiological factors important in pregnancy include hypercoagulability due to maternal physiological changes, pre-eclampsia and eclampsia, cerebral venous thrombosis, paradoxical embolism, postpartum cerebral angiopathy and peripartum cardiomyopathy. Management of patients with pregnancyrelated stroke should generally proceed as for nonpregnant patients, although there are a number of important areas specific to pregnancy which will be considered here.Stroke in young adults aged 15-35 years is more common in women than in men, 1 and women also have poorer outcomes in terms of disability and dependency.2 There has been growing interest in the role of oestrogens in stroke, 3 and risk factors unique to women include pregnancy, use of oral contraceptives, and postmenopausal hormone therapy. Stroke associated with pregnancy has been recognised for many years, and is an uncommon but feared complication contributing to more than 12% of all maternal deaths.4 5 The declining incidence of direct causes of maternal death has led to an increased awareness of nonobstetric factors such as stroke. Clearly, any recognised cause of stroke in young patients may also occur coincidentally during pregnancy, although there are a number of factors associated with pregnancy that have an important aetiological role, and these will be considered here. We will also consider the current scope of the problem, and focus on relevant areas unique to pregnancy, including issues surrounding investigation and treatment options.

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Section: Specific Stroke Syndromes In Pregnancymentioning

confidence: 99%

Stroke in pregnancy and the puerperium

Treadwell

Thanvi

Robinson

2008

Postgraduate Medical Journal

134

114

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“… 1 Cardioembolic stroke in PPCM is reported very rarely. 2 – 4 The PPCM is diagnosed as LV systolic dysfunction (LVEF < 45%), in the last month of pregnancy to 5 months following delivery, and when no other cause is identified for cardiomyopathy. 5 The etiopathogenesis of PPCM is unclear.…”

Section: Discussionmentioning

confidence: 99%

Cardioembolic Stroke with Peripartum Cardiomyopathy: An Unusual Presentation

Koul¹,

Singh²,

Ali³

et al. 2021

Indian Journal of Critical Care Medicine

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A bstract Cardioembolic stroke in a patient with peripartum cardiomyopathy (PPCM) patient is rare despite a higher incidence of thromboembolic events. We report a case of acute right middle cerebral artery territory cardioembolic stroke in a postpartum female as the initial presenting feature of PPCM. The patient was thrombolyzed with intravenous alteplase and had an almost complete neurological recovery. How to cite this article: Nasa P, Mortada M, Ali A, Malhotra V, Koul K, Singh A. Cardioembolic Stroke with Peripartum Cardiomyopathy: An Unusual Presentation. Indian J Crit Care Med 2021;25(1):97–99.

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“…Частота ПКМ неиз-вестна и широко варьирует в разных регионах, хотя предпо-лагается 1 случай ПМК на каждые 3000-4000 живорожден-ных [21]. Тромбы в левом желудочке часто определяется при ПКМ [22], возможна также периферическая эмболизация, приводящая к церебральным инфарктам [23,24].…”

Section: о б з о р ыunclassified

Heart diseases and strokes in young people

Пизова

2014

Neurology, Neuropsychiatry, Psychosomatics

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Peripartum Cardiomyopathy and Stroke

Cited by 16 publications

References 18 publications

Stroke in pregnancy and the puerperium

Stroke in pregnancy and the puerperium

Cardioembolic Stroke with Peripartum Cardiomyopathy: An Unusual Presentation

Heart diseases and strokes in young people

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