Peripartum cardiomyopathy: A review

Bala, Rajni; Mehta, Shailender; Roy, Vandana; Kaur, Geetika; Marvao, Antonio de

doi:10.1016/j.repc.2023.01.029

Cited by 4 publications

(6 citation statements)

References 43 publications

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“…This potentially fatal disease is characterised by severe dysfunction of the LV and cardiac failure. 1–3 29 Lack of reliable guidelines for individuals with previous PPCM on their SSP sets up an uncertainty for healthcare professionals, in which the present study attempts to address. Decisions about future pregnancies are complicated because women with PPCM have the potential for a diminished in LV function alongside possible relapse of PPCM, and even mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Peripartum cardiomyopathy (PPCM) is a rare but potentially life-threatening condition characterised by heart failure (HF) due to left ventricular (LV) systolic dysfunction towards the end of pregnancy or in the early postpartum period, with the absence of any other cause of HF. [1][2][3] Genetics, multiple pregnancies, underweight, pre-eclampsia, infection and hormonal changes were identified as the predictor factors for the incidence of PPCM. 4 The prevalence of PPCM varies depending on the region, it happens in 1:100-1:4000 live births in the USA.…”

Section: Introductionmentioning

confidence: 99%

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Outcomes of subsequent pregnancy in women with peripartum cardiomyopathy: a systematic review and meta-analysis

Wijayanto,

Myrtha,

Lukas

et al. 2024

Open Heart

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IntroductionThe primary concern for women who have experienced peripartum cardiomyopathy (PPCM) is the safety of a subsequent pregnancy (SSP). To maximie decision-making, facilitate effective patient counselling, and ultimately improve maternal and fetal outcomes as a whole, it is critical to comprehend the outcomes of SSP in women who have previously experienced PPCM. This study aimed to evaluate the outcomes of SSP in women with PPCM.MethodsThree databases (PubMed, Scopus, and ScienceDirect) were used to identify relevant studies prior to 17 October 2023. A total of 662 studies were reviewed. Following the abstract and full-text screenings, 18 observational studies were included, out of which 2 were deemed suitable for inclusion in this meta-analysis. The quality assessment was conducted using the Newcastle-Ottawa Scale.ResultsThis study has a total of 487 SSPs. Although recovered left ventricular (LV) function before entering SSP has the potential to be a beneficial prognostic factor, recovered LV function still has a substantial risk of relapse. The mortality rate of PPCM in an SSP ranged from 0% to 55.5%. Persistent LV dysfunction was significantly associated with an increased mortality rate (OR 13.17; 95% CI 1.54 to 112.28; p=0.02) and lower LV ejection fraction (MD −12.88; 95% CI −21.67 to −4.09; p=0.004). Diastolic and right ventricular functions remained unchanged before SSP and at follow-up. The majority of the SSP was observed alongside hypertension, while pre-eclampsia emerged as the predominant hypertensive complication in most studies.ConclusionSSP increases the risk of relapse and mortality in women with a previous history of PPCM. Persistent LV dysfunction prior to the SSP has a higher mortality risk compared with recovered LV function. SSP was also associated with the worsening of LV echocardiography parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Outcomes of subsequent pregnancy in women with peripartum cardiomyopathy: a systematic review and meta-analysis

Wijayanto,

Myrtha,

Lukas

et al. 2024

Open Heart

View full text Add to dashboard Cite

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“…PPCM is characterized by left ventricular systolic dysfunction, often with a reduced ejection fraction below 45%, occurring in previously healthy young women without identifiable cardiac causes [ 4 ]. The etiology of PPCM is complex and multifactorial, involving factors such as oxidative stress, hormonal influences, inflammation, and genetic predisposition.…”

Section: Introductionmentioning

confidence: 99%

“…PPCM is likely multifactorial in origin with several implicated risk factors, these include advanced maternal age, African origin, preeclampsia, use of tocolytics, twin pregnancy, high parity, obesity, poor socioeconomic status, malnutrition, customary birth practices, and selenium deficiency [ 4 ]. The mean age of PPCM onset is typically around 30 to 31 years, with incidence rising with age, especially among women over 40.…”

Section: Introductionmentioning

confidence: 99%

“…Management strategies for PPCM are currently based on general heart failure protocols [ 5 ], with bromocriptine emerging as a specific treatment by inhibiting PRL secretion from the pituitary gland [ 1 , 4 ]. However, the response to treatment varies among patients, highlighting the need for further research into alternative pathophysiological pathways and novel therapeutic targets [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Peripartum Cardiomyopathy: A Case Report of Mortality From a Rare and Potentially Fatal Condition

Perea Rojas,

Seni Hernandez,

Rojas Torres

et al. 2024

J Med Cases

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Peripartum cardiomyopathy (PPCM) poses a significant challenge in maternal health, characterized by heart failure with reduced ejection fraction during late pregnancy or early postpartum. Despite advances in understanding PPCM, it remains life-threatening with substantial maternal morbidity and mortality. This article reviews the epidemiology, etiology, diagnostic challenges, management strategies, and outcomes associated with PPCM. A case report of a 29-year-old woman with PPCM is presented, emphasizing the importance of early recognition and tailored management. The patient’s presentation was marked by atypical symptoms, including dysuria, lumbar pain, persistent fever, and oral intake intolerance. Despite aggressive medical intervention, the patient experienced a tragic outcome, succumbing to cardiopulmonary arrest within 48 h of admission. This case underscores the challenges in diagnosing and managing PPCM, particularly when presenting with nonspecific symptoms and emphasizes the urgent need for improved diagnostic criteria and therapeutic interventions to mitigate adverse outcomes in affected individuals.

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Paro cardiorrespiratorio secundario a miocardiopatía periparto: reporte de un caso

Zúñiga,

Verdugo,

Zavala

2024

Revista Médica Clínica Las Condes

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Peripartum cardiomyopathy: A review

Cited by 4 publications

References 43 publications

Outcomes of subsequent pregnancy in women with peripartum cardiomyopathy: a systematic review and meta-analysis

Outcomes of subsequent pregnancy in women with peripartum cardiomyopathy: a systematic review and meta-analysis

Peripartum Cardiomyopathy: A Case Report of Mortality From a Rare and Potentially Fatal Condition

Paro cardiorrespiratorio secundario a miocardiopatía periparto: reporte de un caso

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