Peripartum Cardiomyopathy

Ro, Angela S.; Frishman, William H.

doi:10.1097/01.crd.0000174805.68081.f7

Cited by 51 publications

(125 citation statements)

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“…Indeed, for unknown reasons, a very small percentage of patients develop dilated cardiomyopathy after pregnancy, a condition designated "peripartum cardiomyopathy." 20 Some genetically manipulated mice recapitulate this association of pregnancy and heart failure, which mechanistically has been attributed to peripartal cardiomyocyte apoptosis. 21,22 However, the cellular and molecular events that cause human peripartum cardiomyopathy remain unknown at this time.…”

Section: Fuzzy-o-logical Hypertrophy?mentioning

confidence: 99%

The Fuzzy Logic of Physiological Cardiac Hypertrophy

2007

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Section: Fuzzy-o-logical Hypertrophy?mentioning

confidence: 99%

The Fuzzy Logic of Physiological Cardiac Hypertrophy

2007

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“…20 The current recommendation is light exercise such as walking. 4,10 Ideal medications intrapartum include hydralazine, nitrates, digoxin, and diuretics. Angiotensinconverting enzyme inhibitors are contraindicated during pregnancy because of their teratogenicity, but these medications are the mainstay of treatment of PPCM after delivery for afterload reduction.…”

Section: Decompensated Heart Failurementioning

confidence: 99%

“…Many etiological processes have been suggested: viral myocarditis, abnormal immune response to pregnancy, maladaptive response to hemodynamic stresses of pregnancy, stress-activated cytokines, excessive prolactin excretion, and prolonged tocolysis. 4,10,17,18 Also, a familial predisposition to PPCM has been reported. [19][20][21] Although underlying genetic variants common to dilated cardiomyopathies are being proposed, 22 a genetic basis specific to PPCM has not been systematically studied.…”

mentioning

confidence: 99%

“…4,10,13 Women can also have arrhythmias, embolic events due to the dilated, dysfunctional left ventricle, and acute myocardial infarction due to decreased perfusion to the coronary arteries. 4,10,35 They can also have other indications typical of heart failure: hypoxia, jugular venous distention, S 3 and S 4 gallop, rales, and hepatomegaly. 35 Blood pressure is often normal or decreased, and tachycardia is common.…”

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Peripartum Cardiomyopathy: Review and Practice Guidelines

Johnson-Coyle

Jensen

Sobey

2012

American Journal of Critical Care

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Peripartum cardiomyopathy, a type of dilated cardiomyopathy of unknown origin, occurs in previously healthy women in the final month of pregnancy and up to 5 months after delivery. Although the incidence is low-less than 0.1% of pregnancies -morbidity and mortality rates are high at 5% to 32%. The outcome of peripartum cardiomyopathy is also highly variable. For some women, the clinical and echocardiographic status improves and sometimes returns to normal, whereas for others, the disease progresses to severe cardiac failure and even sudden cardiac death. In acute care, treatment may involve the use of intravenous vasodilators, inotropic medications, an intra-aortic balloon pump, ventricular-assist devices, and/or extracorporeal membrane oxygenation. Survivors of peripartum cardiomyopathy often recover from left ventricular dysfunction; however, they may be at risk for recurrence of heart failure and death in subsequent pregnancies. Women with chronic left ventricular dysfunction should be managed according to guidelines of the

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“…Ancak ortaya göğüs ağrısı, öksürük, halsizlik, dispne, ortopne, pretibiyal ödem, el ve ayakta terleme gibi semptomlarla birlikte seyreden ve klinik bulguları konjestif kalp yetmezliği ile benzerlik gösteren ortak bir klinik tablo ortaya çıkmaktadır. 5 Olgumuzda, gebelik öncesinde ve peripartum dönemde herhangi bir kardiyak patoloji mevcut olmayıp PPCM için risk faktörü olduğu düşünülen ikiz gebelik ve HELLP sendromu ile sonuçlanan preeklampsi tablosu ve postoperatif dönemde gelişen akut kalp yetmezliği tablosu mevcuttu. Ani gelişen konjestif kalp yetmezliği klinik tablosu sonrası çekilen akciğer grafisinde akciğer ödemi tespit edilmesi, BT ile perikardiyal ve plevral efüzyon saptanması ve sonrasında uygulanan TTE sonucunda LVEF'nin <%30 olması ile hastaya PPCM tanısı konuldu.…”

Section: Olgu Sunumuunclassified