Peripapillary retinal nerve fibre layer thickness and its association with refractive error in Chinese children: the Anyang Childhood Eye Study

Abstract

Retinal nerve fibre layer thickness decreased with increasing AL, higher myopia, bigger cup area, smaller disc and rim area, and a smaller nerve head volume, but the coefficient of determination for all these associations was small. The RNFL in myopes was significantly thinner than emmetropes or hyperopes, but with small absolute differences. The study provides RNFL values for healthy 7-year-old Chinese children. Follow up of this cohort to observe the change of RNFL thickness with myopia and possible change in detected associations with age is planned.

Comparison of Optic Disc Parameters in Hyperopic and Emmetropic Eyes of Healthy Children with HRT and OCT

“…RNFL thickness and its variation among normal children has previously been reported in OCT studies [4,6,17,18]. In our study, the range of the RNFL thickness was narrowest for the average RNFL (about 50 µm), being wider in the quadrants (▶ Table 1).…”

Assessment of macular ganglion cell complex using optical coherence tomography: Impact of a paediatric reference database in clinical practice

“…In the present study, axial length (AL) was not measured; however, AL has minimal influence on macular and peripapillary retinal nerve fibre layer measurements . Other authors showed an influence of AL on OCT measurements and reported that correlations with SE are inverse to those found with AL, as AL increased with decreasing SE . Al Haddad et al also reported a negative correlation between SE and AL in healthy children ( P < 0.001) and assessed the influence of SE on all parameters …”

“…17,18 Other authors showed an influence of AL on OCT measurements and reported that correlations with SE are inverse to those found with AL, as AL increased with decreasing SE. 19,20 Al Haddad et al also reported a negative correlation between SE and AL in healthy children (P < 0.001) and assessed the influence of SE on all parameters. 21 Realini et al suggested that the process for developing imaging reference databases could be improved by standardising eligibility requirements and data collection protocols.…”

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

“…To date, only age 7,8 , refraction 9 or axial length (AL) 10 have been consistently associated with measured pRNFLT across studies. In addition, the majority of large-scale studies assessing these associations were performed in (young) Asian populations 6,[11][12][13][14] . It is unclear whether or not these results can be applied to European, i.e.…”