Peripapillary Retinal Nerve Fiber Layer Thickness Variations with Myopia

Hoh, Sek-Tien; Lim, Marcus; Seah, S.K.W.; Lim, Albert T.H.; Chew, Sek-Jin; Foster, Paul J.; Aung, Tin

doi:10.1016/j.ophtha.2006.01.058

Cited by 107 publications

(71 citation statements)

References 20 publications

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“…Longer eyes and more myopic eyes had a thinner measured RNFL. A recent study by Hoh et al 17 failed to demonstrate a relationship between peripapillary RNFL thickness and refractive error or axial length in 132 young Asian male military subjects. Limitations of that study included the use of first-generation technology OCT; a relatively small sample size; lack of gender, age, or ethnic diversity; and the use of univariate analysis.…”

Section: Discussionmentioning

confidence: 94%

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

et al. 2007

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Purpose-To determine the effects of age, optic disc area, ethnicity, eye, gender, and axial length on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by Stratus OCT (optical coherence tomography).Design-Cross-sectional observational study.Participants-Three hundred twenty-eight normal subjects 18 to 85 years old. Methods-PeripapillaryFast RNFL scans performed by Stratus OCT with a nominal diameter of 3.46 mm centered on the optic disc were performed on one randomly selected eye of each subject.Main Outcome Measures-Linear regression analysis of the effects of age, ethnicity, gender, eye, axial length, and optic disc area on peripapillary RNFL thickness.Results-The mean RNFL thickness for the entire population was 100.1 μm (standard deviation, 11.6). Thinner RNFL measurements were associated with older age (P<0.001); being Caucasian, versus being either Hispanic or Asian (P = 0.006); greater axial length (P<0.001); or smaller optic disc area (P = 0.010). For every decade of increased age, mean RNFL thickness measured thinner by approximately 2.0 μm (95% confidence interval [CI], 1.2-2.8). For every 1-mm-greater axial length, mean RNFL thickness measured thinner by approximately 2.2 μm (95% CI, 1.1-3.4). For every increase in square millimeter of optic disc area, mean RNFL thickness increased by approximately 3.3 μm (95% CI, 0.6-5.6). Comparisons between ethnic groups revealed that Caucasians had mean RNFL values (98.1±10.9 μm) slightly thinner than those of Hispanics (103.7±11.6 μm; P = 0.022) or Asians (105.8±9.2 μm; P = 0.043). There was no relationship between RNFL thickness and eye or gender.Correspondence to Donald L. Budenz, MD, MPH, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136. dbudenz@med.miami.edu. Dr Schuman is currently at the Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Dr Schuman is a co-patent holder of the optical coherence tomography technology. Dr Patella is an employee of Carl Zeiss Meditec. Dr Quigley is a consultant for Carl Zeiss Meditec. NIH Public Access Author ManuscriptOphthalmology. Author manuscript; available in PMC 2010 August 5. Conclusions-Retinal nerve fiber layer thickness, as measured by Stratus OCT, varies significantly with age, ethnicity, axial length, and optic disc area. These variables may need to be taken into account when evaluating patients for diagnosis and follow-up of glaucoma, particularly at the lower boundary of the normal range. Due to the relatively small numbers of subjects of Asian and African descent in the normative database, conclusions regarding the effect of ethnicity should be interpreted with caution.Glaucoma is an optic neuropathy associated with accelerated apoptosis of retinal ganglion cells (RGCs) that manifests as increased cupping of the optic disc and thinning of the retinal nerve fiber layer (RNFL). The diagnosis of glaucoma is currently based on the appearance of the optic disc, RNFL, and standard achromatic perimetry. 1 The optic disc is ...

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Section: Discussionmentioning

confidence: 94%

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

et al. 2007

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“…However, its decreasing ratios varied (2-7 microns per mm) in reports; as such, its changes of RNFL thickness may depend exclusively on different races and age distributions. 15 It is generally known that tilted disc is more prevalent in myopic eyes, and thus this distortion of the optic nerve fibers at the myopic disc may cause a mechanical stress toward the optic nerve fibers, eventually leading to the glaucomatous optic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

OCT based Comparison of RNFL Thickness in Low to Moderate Myopic Eyes with NORMAL and Raised IOP

2016

IJSR

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with raised corrected IOP (≥22mmHg) were included in this cross-sectional study. Three circular scans were obtained for each eye at diameter of 3.4mm around the optic disc using RTVue OCT. A single index of average RNFL thickness throughout 360 degree was obtained. The mean RNFL of (n=60) eyes with raised IOP was compared with age matched randomly selected (n=60) eyes with normal IOP. Results: Mean RNFL was significantly thinner in eyes with raised IOP than in eyes with normal IOP, 91.01 ± 11.95 and 101.52 ± 10.13 respectively. Conclusion: These findings suggest that quantitative differences in RNFL thickness exist between age-matched low to moderate myopic eyes with normal and raised IOP. Thus, all myopic individuals with raised IOP should be considered for OCT to assess for damage of RNFL, as they are at risk of developing glaucoma in future.

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“…4 OKT kullanarak yapılan önceki çalışmalarda yalnız OKT-3 kullanılarak yapılan çalışmalar dü-şünüldüğünde benzer ilişkiler ortaya çıkmasına rağmen; OKT-1 kullanarak yapılan çalışmalar miyoplarda peripapiller RSLT ölçümü için farklı sonuçlar vermiştir. [5][6][7][8][9] Hoh ve ark. miyopi ve RSLT arasındaki ilişkiyi tespit etmek için yaptıkları çalışmada SE'si -0,50 ile -14,25 D arasında değişen toplam 132 sağlıklı erkek olgunun peripapiller RSLT kalınlığını OKT-1 kullanarak değerlendirmişlerdir ve miyopi seviyesi/aksiyel uzunluk ile ortalama RSLT kalınlığı arasında anlamlı bir korelasyon bulamamışlardır.…”

Section: Gereç Ve Yöntemlerunclassified

“…miyopi ve RSLT arasındaki ilişkiyi tespit etmek için yaptıkları çalışmada SE'si -0,50 ile -14,25 D arasında değişen toplam 132 sağlıklı erkek olgunun peripapiller RSLT kalınlığını OKT-1 kullanarak değerlendirmişlerdir ve miyopi seviyesi/aksiyel uzunluk ile ortalama RSLT kalınlığı arasında anlamlı bir korelasyon bulamamışlardır. 7 Korelasyon bulamamalarının sebebi Stratus OKT'nin daha yüksek aksiyel transvers rezolüs-yon taramasına izin vermesi ve OKT-1'den elde edilenlere göre belirgin oranda daha iyi kalitede RSLT imajı sağlaması olabilir. 10 OKT-1 kullanan Kremmer ve ark.…”

Section: Gereç Ve Yöntemlerunclassified

Assessment of Macula and Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Myopia

Özkağnıcı¹,

Tokgöz²

2012

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Çalışmada emetrop ve miyop olgularda retina yapısının optik koherens tomografi (OKT) ile incelenmesi amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma grubu 118'i kadın, 106'sı erkek, toplam 224 olgudan oluşturuldu. Olgular kırma kusuru derecelerine göre birinci grup 0,00/-0,75 D arası (kontrol grubu), ikinci grup -1,00/-3,00 D arası, üçüncü grup -3,25/-6,00 D arası, dördüncü grup ise -6,25/-12,00 D arası olarak dört gruba ayrıldı. Tüm olguların retina sinir lifi tabakası (RSLT) kalınlığı ve makula kalınlığı OKT kullanılarak ölçüldü. B Bu ul lg gu ul la ar r: : Yüksek miyop grupta foveal kalınlık ve volümünde artış tespit edilirken, dış alan dışındaki tüm alanların RSLT kalınlığında azalma bulundu. Ayrıca total makular volüm, dış makular kalınlık ve volümü de azalmıştı. Yüksek miyopik olgularda RSLT'de en fazla incelme %18,6 iç ve %13,1 ile, dış kalınlıkta idi. RSLT kalınlığı, makula kalınlığı ve volüm değerleri ile aksiyel uzunluk/sferik ekivalan arasında zayıf korelasyon mevcuttu. S So on nu uç ç: : Yüksek miyoplarda RSLT'de özellikle iç ve üst kadran incelmesini değerlendirmek çok önemlidir. Foveal çukur ve parafoveolar tepe arasındaki mesafe miyopi ile ters orantılıdır, yani miyopi derecesinde artma makular bölgenin daha düz hâle gelmesine neden olur.A An na ah ht ta ar r K Ke el li im me el le er r: : Miyopi; retina A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : In the study, analysis of retina structure with optical coherence tomography (OCT) in emetropic and myopic cases was aimed. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study group included a total of 224 cases (118 females, 106 males). Cases were divided into four groups: between 0.00/-0.75 D (first group=control group), between -1.00/-3.00 D (second group), between -3.25/-6.00 D (third group) and between -6.25/-12.00 D, according to their refractive error. Thickness of retinal nerve fiber layer (RNFL) and macula was measured using OCT. R Re es su ul lt ts s: : While an increase was detected in foveal thickness and volume in the highly myopic group, a reduction was found in RNFL thickness of all areas except temporal area. Total macular volume, outer macular thickness and volume were also reduced. The highest thinning of RNFL in highly myopic cases was in 13.1% in superior and 18.6% in nasal thickness. There was a weak correlation between RNFL thickness, macular thickness and volume values and axial length/spheric equivalent. C Co on nc cl lu us si io on n: : Assessment of especially nasal and superior quadrant thickness in RNFL is crucial in highly myopics. Distance between foveal pit and parafoveolar tip is inversely proportional with myopia, in other words, increase in degree of myopia causes macular area to become flatter. Bu çalışmada miyop bireylerin retina dokusunun yapısal ve fonksiyonel özelliklerini belirlemek ve bunların miyopinin derecesi ile ilişkisini incelemek amaçlandı. Bu amaçla optik koherens tomografi (OKT) cihazı ile RSLT ve makula kalınlığı ölçümle...

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Peripapillary Retinal Nerve Fiber Layer Thickness Variations with Myopia

Cited by 107 publications

References 20 publications

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

OCT based Comparison of RNFL Thickness in Low to Moderate Myopic Eyes with NORMAL and Raised IOP

Assessment of Macula and Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Myopia

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