Peripapillary Rat Sclera Investigated In Vivo With Polarization-Sensitive Optical Coherence Tomography

Baumann, Bernhard; Rauscher, Sabine; Glösmann, Martin; Götzinger, Erich; Pircher, Michael; Fialová, Stanislava; Gröger, Marion; Hitzenberger, Christoph K.

doi:10.1167/iovs.14-15037

Cited by 32 publications

(31 citation statements)

References 42 publications

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“…[20][21][22] The high resolution of third-generation spectral-domain OCT devices renders in vivo retinal imaging in mice and rats possible, gaining an increasing importance in ophthalmological and neurological preclinical research. [23][24][25][26][27][28][29][30][31][32][33] The obtained results are in good accordance with histological sections of the animals' retinae. 34 The application of OCT technology in rodent models, however, is still challenging, mainly because of the small size of the rodents' eyes.…”

Section: Introductionsupporting

confidence: 82%

Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide

et al. 2016

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BackgroundIn vivo retinal imaging of rodents has gained a growing interest in ophthalmology and neurology. The bedding of the animals with the possibility to perform adjustments in order to obtain an ideal camera-to-eye angle is challenging.MethodsWe provide a guide for a cost-effective, do-it-yourself rodent holder for ocular imaging techniques. The set-up was tested and refined in over 2000 optical coherence tomography measurements of mice and rats.ResultsThe recommended material is very affordable, readily available and easily assembled. The holder can be adapted to both mice and rats. A custom-made mouthpiece is provided for the use of inhalant anaesthesia. The holder is highly functional and assures that the rodent’s eye is the centre of rotation for adjustments in both the axial and the transverse planes with a major time benefit over unrestrained positioning of the rodents.ConclusionWe believe this guide is very useful for eye researchers focusing on in vivo retinal imaging in rodents as it significantly reduces examination times for ocular imaging.

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Section: Introductionsupporting

confidence: 82%

Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide

et al. 2016

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“…In the peripapillary zone, the basket-weave lamellar architecture changes to one in which the collagen and elastin fibers run circumferentially around the ONH opening to which they are closely apposed (Pijanka et al, 2014). A similar ring-like pattern has been detected in rats (Baumann et al, 2014). With experimental glaucoma, the PPS collagen circumferential ring widens substantially (ConeKimball et al, 2013) and the ring-like pattern becomes less orderly (Pijanka et al, 2014) in a manner similar to that seen in human glaucoma at the PPS .…”

Section: Scleral and Onh Changes In Mouse Glaucomamentioning

confidence: 65%

The contribution of the sclera and lamina cribrosa to the pathogenesis of glaucoma

Quigley

2015

Progress in Brain Research

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“…A more detailed analysis of the birefringence of this layer by PS-OCT can be found in ref [112]. Although the limited space does not allow to discuss these applications and results in more detail, it should be mentioned that several papers have reported interesting and useful results of PS-OCT imaging of birefringent structures in animal eyes (cf., e.g., [63,[113][114][115][116]). …”

Section: Imaging and Quantification Of The Retinal Nerve Fiber Layermentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

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Abstract:Optical coherence tomography (OCT) is now a well-established modality for highresolution cross-sectional and three-dimensional imaging of transparent and translucent samples and tissues. Conventional, intensity based OCT, however, does not provide a tissuespecific contrast, causing an ambiguity with image interpretation in several cases. Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the light's polarization state, adding an additional contrast channel and providing quantitative information. In this paper, we review basic and advanced methods of PS-OCT and demonstrate its use in selected biomedical applications. Drexler, and J. G. Fujimoto, eds. (Springer, Cham, 2015), pp. 1137-1162. 6. J. F. de Boer and T. E. Milner, "Review of polarization sensitive optical coherence tomography and Stokes vector determination," J. Biomed. Opt. 7(3), 359-371 (2002). 7. M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Polarization Sensitive Optical Coherence Tomography in the Human Eye," Prog. Retin. Eye Res. 30(6), 431-451 (2011). 8. D. Stifter, "Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography," Appl. Phys. B 88(3), 337-357 (2007). 9. R. C. Jones, "A new calculus for the treatment of optical systems I. Description and discussion of the calculus," J. Opt. Soc. Am. A 31(7), 488-493 (1941). 10. J. J. Gil and E. Bernabeu, "Obtainment of the polarizing and retardation parameters of a non-depolarizing optical system from the polar decomposition of its Mueller matrix," Optik (Stuttg.) 76, 67-71 (1987). 11. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley Interscience, New York, NY, 1983). 12. W. A. Shurcliff and S. S. Ballard, Polarized Light (Van Nostrand, New York, 1964). 13. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. F. de Boer, "In vivo burn depth determination by highspeed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6(4), 474-479 (2001). 14. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11(7), 782-793 (2003). 15. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, "High-speed fiber based polarizationsensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25(18), 1355-1357 (2000). Rylander, "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE J. Sel. Top. Quantum Electron. 5(4), 1159-1167 (1999 Schmidt-Erfurth, and S. Sacu, "Retinal pigment epithelial features in central serous chorioretinopathy identified by polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 57(4), 1595-1603 (2016). 131. C. Schütze, C. Ahlers, M. Pircher, B. Baumann, E. Götzinger, F. Prager, G. Matt, S. Sacu, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Morphologic characteristics of idiopathic juxtafoveal telangiectasia using spectraldomain and po...

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Peripapillary Rat Sclera Investigated In Vivo With Polarization-Sensitive Optical Coherence Tomography

Cited by 32 publications

References 42 publications

Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide

Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide

The contribution of the sclera and lamina cribrosa to the pathogenesis of glaucoma

Polarization sensitive optical coherence tomography – a review [Invited]

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