Peripapillary Nerve Fiber Elevation in Young Healthy Eyes

Yamashita, Takehiro; Sakamoto, Taiji; Yoshihara, Naoya; Terasaki, Hiroto; Tanaka, Minoru; Kii, Yuya; Nakao, Kumiko

doi:10.1167/iovs.16-19484

Cited by 6 publications

(7 citation statements)

References 26 publications

(20 reference statements)

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“…CCT was reported to be significantly thicker in females than males in a study of a Japanese population. [16] In contrast, the current study and studies among Saudi Arabian [2] and Iraqi [26] populations showed no significant correlation between CCT and sex. The use of OCT in measuring CCT as against orbscan used in the study in Japan could be the reason for the variations in the findings as orbscan was reported to overestimate CCT.…”

Section: Discussioncontrasting

confidence: 95%

Ocular parameters and anthropometry in Indo-Trinidadians

Ezinne,

Roodal,

Ekemiri

et al. 2023

Medicine

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To assess ocular parameters and their association with anthropometric measurements in Indo-Trinidadians adults. This was a clinical, descriptive, cross-sectional study of ocular parameters and anthropometry in adults Trinidadians of South Asian descent (Indo-Trinidadian). Ocular parameters were measured using optical coherence tomography, intraocular lens master biometer, and an autorefractor. Weight, height, and body mass index (BMI) were measured by anthropometry. Univariable and multivariable linear regressions were used to determine the association between demographic variables, anthropometric and ocular parameters. A total of 149 participants (298 eyes) comprising of 90 females (60.6%) and 59 males (39.4%). Aged 18 to 67 participated in the study. Males were taller, heavier, and had longer axial lengths than females which were statistically significant (P < .05). Age was negatively correlated with central corneal thickness (CCT) (r = −0.353, P = .044) and retinal nerve fiber layer thickness (r = −0.348, P = .047) but positively correlated with lens thickness (R = 0.881, P < .001). Education level was positively associated with CCT (R = 0.408, P = .018) but negatively associated with lens thickness (r = −0.521, P = .002). Weight was negatively correlated with corneal topography (r = −0.427, P = .013). Height was negatively correlated with cup-to-disc ratio (r = −0.410, P = .018), CCT (r = −0.382, P = .028), and corneal topography (r = −0.453, P = .008). There was no correlation between BMI, ocular parameters and CCT. There was a significant difference in the ocular parameters between males and females of South Asian descent in Trinidad and Tobago. Weight was negatively associated with the corneal topography. Height was negatively associated with the cup-to-disc ratio, central corneal thickness, and corneal topography. BMI had no statistically significant association with the ocular parameters investigated.

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Section: Discussioncontrasting

confidence: 95%

Ocular parameters and anthropometry in Indo-Trinidadians

Ezinne,

Roodal,

Ekemiri

et al. 2023

Medicine

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“…Thus the pNFE is a characteristic finding of myopia. 14 The pNFE was observed more frequently in the CC and SC groups than in the NC group. However, there was no significant difference in the incidence of pNFE between the CC and SC groups.…”

Section: Discussionmentioning

confidence: 88%

“…The pNFE is the elevation of the nerve fiber layer, which is frequently observed in the nasal peripapillary area of the optic disc. 14 The presence of the pNFE was determined by examining the color fundus photographs, SLO images, and optic disc cross-sectional OCT images. The definition of a pNFE was a white-colored tissue similar to the optic disc rim by ophthalmoscopy, tissue on the optic disc rim with a clear inner margin but no clear outer margin by SLO, and an elevated tissue continuous with the optic disc with the same reflectivity as the ganglion cell-inner plexiform layer.…”

Section: Assessments Of Peripapillary Nerve Fiber Elevation (Pnfe)mentioning

confidence: 99%

Relationship Between Funduscopic Conus and Optic Disc Factors Associated with Myopia in Young Healthy Eyes

Terasaki

Yamashita

Tanaka

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine the relationship between funduscopic findings in myopic eyes and the prevalence and structure of the conus in the optical coherence tomographic (OCT) images. METHODS. A prospective observational cross-sectional study of 121 right eyes of 121 young healthy volunteers. All participants underwent color fundus photography (CFP), scanning laser ophthalmoscopy, and OCT. Based on the OCT analyses, the area between the edge of the ellipsoid zone (EZ) and that of choroid was defined as the "choroidal conus (CC)", and the area between the edge of the choroid and the scleral edge as the "scleral conus (SC)". The eyes were classified into three groups such as the non-conus (NC) group, CC group, and SC group. The differences in the axial length, optic disc tilt, ovality ratio, papillomacular position angle, and peripapillary nerve fiber elevation (pNFE) between the three groups were determined. RESULTS. CFPs detected a conus in 79 eyes (65.3 %). The outer border of the conus in CFPs corresponded with the edge of the EZ in the OCT in all subjects. Thirty-seven eyes had CC alone (CC group) and 42 eyes had both CC and SC (SC group). The CC and SC groups had longer axial lengths and more frequent pNFEs than the NC group. There was a significant difference in the optic disc tilt and ovality ratio between the CC and SC groups. CONCLUSIONS. The eyes with SC tend to have larger optic disc tilt and smaller ovality ratio than the eyes with CC only.

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“…In cluster NS/N/NI, visual sensitivity decreased with increasing AL, not only with the Goldmann III target, but also with the Goldmann V target. The reason for this is not entirely clear, but structural changes, such as a hump of retinal nerve fibers (nasal hump 55 or peripapillary nerve fiber elevation [pNFE] 56 ) has been reported in the nasal retina area in eyes with long AL, probably because the retina is dragged posteriorly as the AL increases, even if the fundus lacks pathological myopic findings. 56 These structural changes are more prominent with the increase of the eye ball, and this may be the reason why visual sensitivity, measured with both Goldmann III and V targets, is decreased with the increase of AL.…”

Section: Discussionmentioning

confidence: 99%

“…In eyes with the nasal hump or pNFE due to increase of AL, a conus was usually present on the side opposite the elevation. 56 As the target is much larger with Goldmann V (64 mm 2 ), compared with Goldmann III (4 mm 2 ), the possibility that the projected light overlaps with the conus is much higher with the larger size target (e.g., due to small eye movements). This may be another reason why visual sensitivity measured with Goldmann V target in cluster T decreased with increasing AL, whereas that phenomenon was not observed with the Goldmann III target.…”

Section: Discussionmentioning

confidence: 99%

Goldmann V Standard Automated Perimetry Underestimates Central Visual Sensitivity in Glaucomatous Eyes with Increased Axial Length

Yanagisawa

Murata

Fujino

et al. 2017

Trans. Vis. Sci. Tech.

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PurposeTo investigate the effect of axial length (AL) on the structure–function relationship between retinal nerve fiber layer (RNFL) thickness measurements and visual field (VF) sensitivity measured with Goldmann III and V.MethodThere were 85 eyes of 85 patients with primary open angle glaucoma included in the current study. Optical coherence tomography and VF (Humphrey Field Analyzer 24-2 or 30-2) measurements with Goldmann III and V targets were carried out in all patients. The optic disc and the VF were divided into six clusters and the relationship between circumpapillary RNFL (cpRNFL) thickness and VF sensitivity (with Goldmann III or V), age, and AL were investigated in each cluster.ResultVisual sensitivity with Goldmann III (19.3 ± 11.7 dB, mean ± standard deviation) was significantly lower than that with Goldmann V (24.6 ± 11.0 dB, P < 0.001, linear mixed model). Visual sensitivities with both Goldmann III and V were significantly correlated with cpRNFL thickness in all clusters. Visual sensitivity decreased with increasing AL in the nasal retinal area for both targets, however, this phenomenon was only observed with the Goldmann V target in the temporal area.ConclusionVisual sensitivity measured with the size V target decreases with increasing AL in the temporal area, which corresponds to the papillomacular bundle. In the nasal retinal area, visual sensitivity decreases with the increase of AL for both Goldmann III and Goldmann V.Translational RelevanceCareful consideration is needed when measuring visual sensitivity using Goldmann V target in glaucomatous eyes with increased AL.

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Peripapillary Nerve Fiber Elevation in Young Healthy Eyes

Cited by 6 publications

References 26 publications

Ocular parameters and anthropometry in Indo-Trinidadians

Ocular parameters and anthropometry in Indo-Trinidadians

Relationship Between Funduscopic Conus and Optic Disc Factors Associated with Myopia in Young Healthy Eyes

Goldmann V Standard Automated Perimetry Underestimates Central Visual Sensitivity in Glaucomatous Eyes with Increased Axial Length

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