Peripapillary Diffuse Chorioretinal Atrophy in Children as a Sign of Eventual Pathologic Myopia in Adults

Yokoi, Tae; Jonas, Jost B.; Shimada, Noriaki; Nagaoka, Natsuko; Moriyama, Muka; Yoshida, Takeshi; Ohno‐Matsui, Kyoko

doi:10.1016/j.ophtha.2016.04.029

Cited by 66 publications

(55 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 The reasons for this potential association have remained inconclusive. Recent histologic studies have suggested that myopic axial elongation of the eye is associated with thinning of the sclera and choroid most marked at the posterior pole while the thickness of Bruch's membrane in all regions of the eye did not decrease significantly with longer axial length.…”

Section: Discussionmentioning

confidence: 99%

“…9,15 In a recent longitudinal study on 35 eyes of adult patients with signs of myopic maculopathy, who were aged 37.0 6 5.1 years (range, 33-42 years), 29 of the 35 eyes (83%) showed a parapapillary diffuse choroidal atrophy (PDCA) at the initial visit (age 10.5 6 2.6 years; range, 5-15 years), with a mean axial length of 27.8 6 1.2 mm (range, 25.5-29.7 mm). 16 Results indicated that PDCA was confined to the area temporal to the optic nerve head outside of the parapapillary alpha, beta, gamma, or delta zones. 16 The study suggested that the presence of PDCA in children with high axial myopia might be a biomarker for eventually developing pathologic myopia in adulthood.…”

mentioning

confidence: 96%

“…16 Results indicated that PDCA was confined to the area temporal to the optic nerve head outside of the parapapillary alpha, beta, gamma, or delta zones. 16 The study suggested that the presence of PDCA in children with high axial myopia might be a biomarker for eventually developing pathologic myopia in adulthood.…”

mentioning

confidence: 96%

“…1, 2). 16 Statistical analysis was carried out using a commercially available statistical software package (SPSS for Windows, version 22.0; SPSS, Inc., Chicago, IL, USA). We calculated the mean and the standard deviations of the thickness of the choroid at the various measurement locations.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Parapapillary Diffuse Choroidal Atrophy in Children Is Associated With Extreme Thinning of Parapapillary Choroid

Yokoi

Zhu

et al. 2017

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

mentioning

confidence: 96%

mentioning

confidence: 99%

See 2 more Smart Citations

Parapapillary Diffuse Choroidal Atrophy in Children Is Associated With Extreme Thinning of Parapapillary Choroid

Yokoi

Zhu

et al. 2017

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

“…Further studies on choroidal blood flow in RP models using EDI SD‐OCT may help determine the relationship of choroidal thinning to blood flow alteration and reveal the role of the choroid in RP. Furthermore, RPE cell death has been implicated in choriocapillaris atrophy . In this study, TEM showed that RPE cells became lobulated at P1, indicating that they were aging.…”

Section: Discussionmentioning

confidence: 52%

N‐methyl‐N‐nitrosourea induces retinal degeneration in the rat via the inhibition of NF‐κB activation

Xiong

Song

et al. 2016

Cell Biochemistry & Function

View full text Add to dashboard Cite

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by the loss of photoreceptor cells through apoptosis. N-methyl-N-nitrosourea (MNU) is an alkylating toxicant that induces photoreceptor cell death resembling hereditary RP. This study aimed to investigate the role of nuclear factor κB (NF-κB) in MNU-induced photoreceptor degeneration. Adult rats received a single intraperitoneal injection of MNU (60 mg/kg bodyweight). Hematoxylin and eosin staining demonstrated progressive outer nuclear layer (ONL) loss after MNU treatment. Transmission electron microscopy revealed nuclear pyknosis, chromatin margination in the photoreceptors, increased secondary lysosomes, and lobulated retinal-pigmented epithelial cells in MNU-treated rats. Numerous photoreceptor cells in the ONL showed positive TUNEL staining and apoptosis rate peaked at 24 hours. Enhanced depth imaging spectral-domain optical coherence tomography showed ONL thinning and decreased choroid thickness. Electroretinograms showed decreased A wave amplitude that predominated in scotopic conditions. Western blot analysis showed that nuclear IκBα level increased, whereas nuclear NF-κB p65 decreased significantly in the retinas of MNU-treated rats. These findings indicate that MNU leads to selective photoreceptor degradation, and this is associated with the inhibition of NF-κB activation.

show abstract

Four-Year Progression of Myopic Maculopathy in Children and Adolescents With High Myopia

Jiang,

Wang,

Xiao

et al. 2024

JAMA Ophthalmol

View full text Add to dashboard Cite

ImportanceIndividuals with high myopia younger than 18 years are at relatively high risk of progressively worsening myopic maculopathy. Additional studies are needed to investigate the progression of myopic maculopathy in this age group, as well as the risk factors associated with progression.ObjectiveTo investigate the 4-year progression of myopic maculopathy in children and adolescents with high myopia, and to explore potential risk factors.Design, Setting, and ParticipantsThis hospital-based observational study with 4-year follow-up included a total of 548 high myopic eyes (spherical power −6.00 or less diopters) of 274 participants aged 7 to 17 years. Participants underwent comprehensive ophthalmic examination at baseline and 4-year follow-up. Myopic maculopathy was accessed by the International Photographic Classification and Grading System. The data analysis was performed from August 1 to 15, 2023.Main Outcomes and MeasuresThe progression of myopic maculopathy progression over 4 years and associated risk factors.ResultsThe 4-year progression of myopic maculopathy was found in 67 of 548 eyes (12.2%) of 274 participants (138 girls [50.4%] at baseline and 4-year follow-up) with 88 lesion changes, including new signs of the tessellated fundus in 16 eyes (18.2%), diffuse atrophy in 12 eyes (13.6%), patchy atrophy in 2 eyes (2.3%), lacquer cracks in 9 eyes (10.2%), and enlargement of diffuse atrophy in 49 eyes (55.7%). By multivariable analysis, worse best-corrected visual acuity (odds ratio [OR], 6.68; 95% CI, 1.15-38.99; P = .04), longer axial length (AL) (OR, 1.73; 95% CI, 1.34-2.24; P &lt; .001), faster AL elongation (OR, 302.83; 95% CI, 28.61-3205.64; P &lt; .001), and more severe myopic maculopathy (diffuse atrophy; OR, 4.52; 95% CI, 1.98-10.30; P &lt; .001 and patchy atrophy; OR, 3.82; 95% CI, 1.66-8.80; P = .002) were associated with myopic maculopathy progression.Conclusions and RelevanceIn this observational study, the progression of myopic maculopathy was observed in approximately 12% of pediatric high myopes for 4 years. The major type of progression was the enlargement of diffuse atrophy. Risk factors for myopic maculopathy progression were worse best-corrected visual acuity, longer AL, faster AL elongation, and more severe myopic maculopathy. These findings support consideration of follow-up in these individuals and trying to identify those at higher risk for progression.

show abstract

Peripapillary Diffuse Chorioretinal Atrophy in Children as a Sign of Eventual Pathologic Myopia in Adults

Cited by 66 publications

References 17 publications

Parapapillary Diffuse Choroidal Atrophy in Children Is Associated With Extreme Thinning of Parapapillary Choroid

Parapapillary Diffuse Choroidal Atrophy in Children Is Associated With Extreme Thinning of Parapapillary Choroid

N‐methyl‐N‐nitrosourea induces retinal degeneration in the rat via the inhibition of NF‐κB activation

Four-Year Progression of Myopic Maculopathy in Children and Adolescents With High Myopia

Contact Info

Product

Resources

About