Peripapillary choroidal vascular layers: the Beijing Eye Study

Xu, Jie; Wang, Ya Xing; Jiang, Ruming; Wei, Wen Bin; Xu, Liang; Jonas, Jost B

doi:10.1111/aos.13379

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…20,21 The thickness of the parapapillary choroid was measured on a circular OCT scan with a diameter of 3.4 mm around the optic nerve head center. 23 The rotation of the optic disc around the vertical optic disc axis and the optic disc rotation around the horizontal disc axis was assessed on OCT scans, which ran through the center on the optic nerve head in the horizontal direction and in the vertical direction (Fig. 3).…”

Section: Methodsmentioning

confidence: 99%

Parapapillary Beta Zone and Gamma Zone in a Healthy Population: The Beijing Eye Study 2011

Zhang

Wang

Wei

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Section: Methodsmentioning

confidence: 99%

Parapapillary Beta Zone and Gamma Zone in a Healthy Population: The Beijing Eye Study 2011

Zhang

Wang

Wei

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…The scans obtained during our research allowed the precise determination of the individual layers of the choroid. The method suggested by Branchini et al [ 34 ] for analyzing vessel lumen diameter has been frequently applied in various studies [ 22 , 36 , 37 ]. According to previous studies, MSVL is defined as the layer containing medium-sized choroidal vessels measuring ≤100 μm, and LVLS is defined as the outer choroidal layer containing large choroidal vessels measuring ≥100 μm [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…A correlation between choroidal dimensions and patient characteristics, such as age, refractive error, corneal refractive power, ethnicity, body height, and sexual maturation, has been observed in numerous studies involving healthy human subjects [ 17 , 18 , 19 , 20 ]. Many studies have investigated choroidal profiles in humans [ 21 , 22 , 23 ]. The morphological features of the choroid in both physiological and pathological conditions indicate that this vascular structure plays a crucial role in many chorioretinal disorders [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Morphological and Morphometric Analysis of Canine Choroidal Layers Using Spectral Domain Optical Coherence Tomography

Zwolska

Balicki

Balicka

2023

IJERPH

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The choroid, a multifunctional tissue, has been the focus of research interest for many scientists. Its morphology and morphometry facilitate an understanding of pathological processes within both the choroid and retina. This study aimed to determine the choroidal layer thicknesses in healthy, mixed-breed mesocephalic dogs, both male (M) and female (F), using spectral domain optical coherence tomography (SD-OCT) with radial, cross-sectional, and linear scans. The dogs were divided into two groups based on age: middle-aged (MA) and senior (SN). Thicknesses of choroidal layers, namely RPE–Bruch’s membrane–choriocapillaris complex (RPE-BmCc) with tapetum lucidum in the tapetal fundus, the medium-sized vessel layer (MSVL), and the large vessel layer with lamina suprachoroidea (LVLS), as well as whole choroidal thickness (WCT), were measured manually using the caliper function integrated into the OCT software. Measurement was performed dorsally and ventrally at a distance of 5000–6000 μm temporally and nasally at a distance of 4000–7000 μm to the optic disc on enhanced depth scans. The measurements were conducted temporally and nasally in both the tapetal (temporal tapetal: TempT, nasal tapetal: NasT) and nontapetal (temporal nontapetal: TempNT, nasal nontapetal: NasNT) fundus. The ratio of the MSVL thickness to the LVLS thickness for each region was calculated. In all examined dogs, the RPE-BmCc in the dorsal (D) region and MSVL in the Tt region were significantly thicker than those in the other regions. The MSVL was thinner in the ventral (V) region than in the D, TempT, TempNT and NasT regions. The MSVL was significantly thinner in the NasNT region than in the D region. LVLS thickness and WCT were significantly greater in the D and TempT regions than those in the other regions and significantly lesser in the V region than those in the other regions. The MSVL-to-LVLS thickness ratio did not differ between the age groups. Our results reveal that the choroidal thickness profile does not depend on age. Our findings can be used to document the emergence and development of various choroidal diseases in dogs in the future.

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“…As shown in clinical studies, the thickness of the choroid decreases with a longer axial length, most markedly in the subfoveal region. 102 – 104 This decrease in choroidal thickness has been shown to affect the layers of medium and large choroidal vessels primarily, whereas the thickness of the choriocapillaris is not, or is only marginally, associated with a longer axial length. 101 Correspondingly, the ratio of the large choroidal vessel layer and of the medium choroidal vessel layer to total choroidal thickness decreases, and the ratio of the choriocapillaris increases with longer axial length.…”

Section: Choroidmentioning

confidence: 99%

IMI—Nonpathological Human Ocular Tissue Changes With Axial Myopia

Jonas

Spaide

Ostrin

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To describe nonpathological myopia-related characteristics of the human eye. Methods Based on histomorphometric and clinical studies, qualitative and quantitative findings associated with myopic axial elongation are presented. Results In axial myopia, the eye changes from a spherical shape to a prolate ellipsoid, photoreceptor, and retinal pigment epithelium cell density and total retinal thickness decrease, most marked in the retroequatorial region, followed by the equator. The choroid and sclera are thin, most markedly at the posterior pole and least markedly at the ora serrata. The sclera undergoes alterations in fibroblast activity, changes in extracellular matrix content, and remodeling. Bruch's membrane (BM) thickness is unrelated to axial length, although the BM volume increases. In moderate myopia, the BM opening shifts, usually toward the fovea, leading to the BM overhanging into the nasal intrapapillary compartment. Subsequently, the BM is absent in the temporal region (such as parapapillary gamma zone), the optic disc takes on a vertically oval shape, the fovea–optic disc distance elongates without macular BM elongation, the angle kappa reduces, and the papillomacular retinal vessels and nerve fibers straighten and stretch. In high myopia, the BM opening and the optic disc enlarge, the lamina cribrosa, the peripapillary scleral flange (such as parapapillary delta zone) and the peripapillary choroidal border tissue lengthen and thin, and a circular gamma and delta zone develop. Conclusions A thorough characterization of ocular changes in nonpathological myopia are of importance to better understand the mechanisms of myopic axial elongation, pathological structural changes, and psychophysical sequelae of myopia on visual function.

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Peripapillary choroidal vascular layers: the Beijing Eye Study

Cited by 7 publications

References 34 publications

Parapapillary Beta Zone and Gamma Zone in a Healthy Population: The Beijing Eye Study 2011

Parapapillary Beta Zone and Gamma Zone in a Healthy Population: The Beijing Eye Study 2011

Morphological and Morphometric Analysis of Canine Choroidal Layers Using Spectral Domain Optical Coherence Tomography

IMI—Nonpathological Human Ocular Tissue Changes With Axial Myopia

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