Peripapillary choroidal thickness in patients with chronic obstructive pulmonary disease

Özçimen, Muammer; Sakarya, Yaşar; Kurtipek, Ercan; Bekçi, Taha Tahir; Göktaş, Sertan; Sakarya, Rabia; Yener, Halil İbrahim; Demir, Lütfi Saltuk; Erdoğan, Erkan; Ivacık, Ismail Senol; Alpfidan, İsmail; Bukus, Abdulkadir

doi:10.3109/15569527.2015.1004079

Cited by 34 publications

(54 citation statements)

References 28 publications

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“…Whilst better segmentation algorithms are already available to overcome the current limitations, the biggest challenge is that choroidal thinning undergoes significant diurnal fluctuations (Kinoshita et al, 2016) and its thinning is seen in many other conditions, including aging (Barteselli et al, 2012), myopia (Ho et al, 2013), uveitis (Baltmr et al, 2014), chronic obstructive pulmonary disease (Ozcimen et al, 2016). It also has limited application in the detection of age-related macular degeneration (Pilotto et al, 2015; Yiu et al, 2015) and glaucoma (Li et al, 2015; Toprak et al, 2016).…”

Section: Retinal Biomarkersmentioning

confidence: 99%

The Eye As a Biomarker for Alzheimer's Disease

et al. 2016

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. It is the leading cause of dementia and the number of cases are projected to rise in the next few decades. Pathological hallmarks of AD include the presence of hyperphosphorylated tau and amyloid protein deposition. Currently, these pathological biomarkers are detected either through cerebrospinal fluid analysis, brain imaging or post-mortem. Though effective, these methods are not widely available due to issues such as the difficulty in acquiring samples, lack of infrastructure or high cost. Given that the eye possesses clear optics and shares many neural and vascular similarities to the brain, it offers a direct window to cerebral pathology. These unique characteristics lend itself to being a relatively inexpensive biomarker for AD which carries the potential for wide implementation. The development of ocular biomarkers can have far implications in the discovery of treatments which can improve the quality of lives of patients. In this review, we consider the current evidence for ocular biomarkers in AD and explore potential future avenues of research in this area.

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Section: Retinal Biomarkersmentioning

confidence: 99%

The Eye As a Biomarker for Alzheimer's Disease

et al. 2016

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“…Spectral Domain‐Optical coherence tomography (SD‐OCT) is an easily applied, non‐invasive and non‐contact imaging modality obtaining detailed in vivo assessment of retina and choroid . It has recently gained an important role in the diagnosis and follow‐up of retinal diseases and ocular involvements of neurodegenerative disorders . Near‐infrared light is used in OCT to analyse the integrity of ganglion cells [the ganglion cell layer (GCL)] and the axons [the retinal nerve fibre layer (RNFL)] in the optic nerve.…”

Section: Introductionmentioning

confidence: 99%

Correlatıon of neutrophyle/lymphocyte ratio and pulmonary parameters with optic coherence tomography findings in stable chronic obstructive pulmonary disease

Özer

Ogan

2020

Clinical Respiratory J

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Introduction To examine the correlation of pulmonary functions and neutrophyle/lymphocyte ratio (NLR) with optic coherence tomography findings in stable chronic obstructive pulmonary disease (COPD). Methods Fifty‐five COPD (110 eyes) and 48 control cases (96 eyes) were enrolled. COPD patients were grouped as Group 1 (mild‐moderate) and Group 2 (severe) according to GOLD classification. Subfoveal choroidal thickness (SFCT), ganglion cell‐inner plexiform layer (GCIP) and retinal nerve fiber layer (RNFL) analysis by SD‐OCT were performed in follow up. NLR was calculated by blood cell count. Results Inferior RNFL and average GCIP of COPD were lower than control during the initial and sixth month examination (P = .002, P < .001, respectively). Average RNFL and SFCT were lower in COPD patients in sixth month examination (P = .020, P = .015, respectively). Average, temporal, inferior, nasal RNFL and SFCT in sixth month examination were significantly lower in severe COPD (P < .05 for all), but average GCIP were similar (P = .015). Disease duration, Modified Medical Research Council (mMRC) and attacks/year showed significant negative correlations, whereas forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC) showed significant positive correlations with OCT values. NLR was significantly higher in COPD cases compared to control (P < .001) and had a negative correlation with GCIP values. Conclusion Chronic obstructive pulmonary disease severity is shown to have a negative effect on OCT measurements. SD‐OCT can reflect severity of inflammation, and suggested to be used in follow up of COPD cases. NLR may have a role to predict the ganglion cell damage in COPD patients.

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“…Ozcimen et al. ) demonstrated that the peripapillary choroid in the inferior segments of patients with COPD was significantly thinner than other peripapillary choroid segments and also thinner than those of control patients. In COPD, choroidal thinning might be due to hypoxia and vascular endothelial dysfunction, making the choroid more susceptible to retinal and choroidal diseases (Ozcimen et al.…”

Section: Methodsmentioning

confidence: 97%

“…Three studies evaluated the peripapillary choroidal thickness of patients with COPD (Table ) (Ozcimen et al. ; Ugurlu et al. ; Gok et al.…”

Section: Methodsmentioning

confidence: 99%

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Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

Vaes

Spruit

Theunis

et al. 2018

Acta Ophthalmologica

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Chronic obstructive pulmonary disease (COPD) is a complex disease with many patients suffering from cardiovascular comorbidity. However, cardiovascular diseases remain often undiagnosed in COPD. Assessment of the retinal microvasculature can provide value in cardiovascular profiling of these patients. Retinal microvascular assessment carried out via a noninvasive eye exam represents an easy to use tool when examining patients with COPD. The purpose of this review was to provide an overview of studies assessing structural and functional changes in the retinal microvasculature of patients with COPD. Findings demonstrated that structural and functional microvascular changes were more common and severe in COPD patients as compared to non-COPD controls, although few retinal investigations have been performed in patients with COPD. As cardiovascular comorbidities are highly prevalent in COPD, we advocate more research to investigate the value of an eye exam for microvascular phenotyping of COPD patients.

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Peripapillary choroidal thickness in patients with chronic obstructive pulmonary disease

Cited by 34 publications

References 28 publications

The Eye As a Biomarker for Alzheimer's Disease

The Eye As a Biomarker for Alzheimer's Disease

Correlatıon of neutrophyle/lymphocyte ratio and pulmonary parameters with optic coherence tomography findings in stable chronic obstructive pulmonary disease

Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

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