Peripapillary Choroidal Thickness and Retinal Nerve Fiber Layer in Untreated Patients with Obstructive Sleep Apnea-Hypopnea Syndrome: A Case–Control Study

Yazgan, Serpil; Erboy, Fatma; Çelik, Hacı Uğur; Örnek, Tacettin; Uğurbaş, Suat Hayri; Kokturk, Firuzan; Ayar, Orhan; Akdemir, Mehmet; Çelik, Erkan

doi:10.1080/02713683.2016.1266661

Cited by 12 publications

(9 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This highly vascularized nature of the choroid, which can be assessed by non-invasive imaging, has drawn attention to the choroid in a variety of systemic diseases, such as the metabolic, inflammatory, and the systemic vascular disease ( 88 ). Peripapillary CT measurements have also been attempted in patients with systemic illnesses ( 24 , 89 – 93 ) such as diabetes ( 23 , 94 – 97 ), thyroid diseases ( 98 , 99 ), and pulmonary diseases ( 25 , 100 ) ( Table 3 ). Yazgan et al ( 94 ) showed that the macular and peripapillary choroid was significantly thicker in pre-diabetic patients than in healthy controls at all 15 measuring points.…”

Section: Choroidal Thickness Measurement Beyond the Maculamentioning

confidence: 99%

“…Regarding peripapillary CT in patients with pulmonary diseases, Ozcimen et al ( 25 ) showed that subfoveal and peripapillary CT in patients with chronic obstructive pulmonary disease tended to be lower than those in the healthy control group, however, the difference was not statistically significant. Yazgan et al ( 100 ) measured subfoveal and peripapillary CT in patients with sleep apnea-hypopnea syndrome and normal controls and found that subfoveal CT was lower in all sleep apnea-hypopnea syndrome subgroups than in the control group. However, peripapillary CT in all sectors was lower only in the moderate and severe subgroups than in the healthy controls.…”

Section: Choroidal Thickness Measurement Beyond the Maculamentioning

confidence: 99%

See 1 more Smart Citation

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

Kim

2021

Front. Med.

View full text Add to dashboard Cite

Enhanced depth imaging optical coherence tomography (EDI-OCT) and swept-source OCT (SS-OCT) have emerged as essential diagnostic tools in the study and management of various chorioretinal diseases. Evidence from early clinical studies using EDI-OCT and SS-OCT indicates that choroidal dysfunction plays a major role in the pathogenesis of chorioretinal diseases. Measurement of choroidal thickness (CT) has already become a major research and clinical method, and CT is considered as an indicator of choroidal status in a variety of ophthalmic diseases. Recently, CT measurement has also been proposed as a non-invasive marker for the early detection and monitoring of various systemic diseases. Among the several possible CT measurement locations, subfoveal CT has rapidly become a reliable parameter for measuring CT in healthy and diseased eyes. Moreover, recent advancements in OCT technology have enabled faster and wider imaging of the posterior part of the eye, allowing the various changes in CT as measured outside the macula to be shown accordingly. In this review, we first provide an overview of the results of clinical studies that have analyzed the healthy macular choroid and that in various chorioretinal diseases, and then summarize the current understanding of the choroid outside the macula. We also examine the CT profile as an index that encompasses both within and outside of the macula. Furthermore, we describe the clinical applications of ultrawide OCT, which enables visualization of the far periphery, and discuss the prospects for the development of more reliable choroidal parameters that can better reflect the choroid's characteristics.

show abstract

Section: Choroidal Thickness Measurement Beyond the Maculamentioning

confidence: 99%

Section: Choroidal Thickness Measurement Beyond the Maculamentioning

confidence: 99%

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

Kim

2021

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Numerous studies have reported significant reduction, while other studies have found no difference in RNFL thickness in OSA patients compared to normal controls [118,[121][122][123][164][165][166][167][168][169][170][171][172][173]. Recently, numerous meta-analyses have been published, in which all found a significant reduction of average RNFL thickness in OSA patients [122,123,166,167,174].…”

Section: Retinal Nerve Fiber Layer and Ganglion Cell Layermentioning

confidence: 99%

The Associations of Obstructive Sleep Apnea and Eye Disorders: Potential Insights into Pathogenesis and Treatment

Ahn

Gorin²

2021

Curr Sleep Medicine Rep

View full text Add to dashboard Cite

Purpose of Review Obstructive sleep apnea (OSA) patients are at significantly increased risks for cardiovascular and cerebrovascular morbidities. Recently, there has been heightened interest in the association of OSA with numerous ocular diseases and possible improvement of these conditions with the initiation of OSA treatment. We reviewed the current evidence with an emphasis on the overlapping pathogeneses of both diseases. Recent Findings Currently available literature points to a substantial association of OSA with ocular diseases, ranging from those involving the eyelid to optic neuropathies and retinal vascular diseases. Since the retina is one of the highest oxygen-consuming tissues in the body, the intermittent hypoxia and hypercapnia ensuing in OSA can have deleterious effects on ocular function and health. Tissue hypoxia, autonomic dysfunction, microvascular dysfunction, and inflammation all play important roles in the pathogenesis of both OSA and ocular diseases. Whether OSA treatment is capable of reversing the course of associated ocular diseases remains to be determined. It is anticipated that future therapeutic approaches will target the common underlying pathophysiologic mechanisms and promote favorable effects on the treatment of known associated ocular diseases. Summary Emerging evidence supports the association of ocular diseases with untreated OSA. Future studies focusing on whether therapeutic approaches targeting the common pathophysiologic mechanisms will be beneficial for the course of both diseases are warranted.

show abstract

“…In OSA, an increase in potent vasoconstrictors such as endothelin, contribute to macro and microvascular damage. Indeed, published data has confirmed thinning of the retinal nerve fiber layer (RNFL) in participants with OSA [ 31 – 47 ]. Similar to peripheral nerves, it is thought that hypoxic damage during sleep and vascular dysregulation drive RNFL thinning in OSA [ 32 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Differential effects of obstructive sleep apnea on the corneal subbasal nerve plexus and retinal nerve fiber layer

et al. 2022

View full text Add to dashboard Cite

Purpose Obstructive sleep apnea (OSA) is an established independent risk factor for peripheral neuropathy. Macro and microvascular changes have been documented in OSA, including high levels of potent vasoconstrictors. In diabetes, vasoconstriction has been identified as an underlying risk factor for corneal neuropathy. This study sought to establish a potential relationship between OSA and corneal nerve morphology and sensitivity, and to determine whether changes in corneal nerves may be reflective of OSA severity. Design Single center cross-sectional study. Methods Sixty-seven patients were stratified into two groups: those with OSA and healthy controls. Groups were matched for age, sex, race, smoking, and dry eye status. Outcome measures included serologies, a dilated fundus exam, dry eye testing, anthropometric parameters, corneal sensitivity, subbasal nerve plexus morphology, retinal nerve fiber layer (RNFL) thickness, and the use of questionnaires to assess symptoms of dry eye disease, risk of OSA, and continuous positive airway pressure (CPAP) compliance. Results No significant differences were observed in corneal nerve morphology, sensitivity, or the number of dendritic cells. In the OSA test group, RNFL thinning was noted in the superior and inferior regions of the optic disc and peripapillary region. A greater proportion of participants in the OSA group required a subsequent evaluation for glaucoma than in the control. In those with OSA, an increase in the apnea hypopnea index was associated with an increase in optic nerve cupping. Conclusions OSA does not exert a robust effect on corneal nerves. OSA is however, associated with thinning of the RNFL. Participants with glaucomatous optic nerve changes and risk factors for OSA should be examined as uncontrolled OSA may exacerbate glaucoma progression.

show abstract

Peripapillary Choroidal Thickness and Retinal Nerve Fiber Layer in Untreated Patients with Obstructive Sleep Apnea-Hypopnea Syndrome: A Case–Control Study

Abstract: In OSAHS patients, PPCT, CMCT, and RNFL were significantly thinner compared with the control group. These results may explain why OSAHS patients are prone to normotensive glaucoma.

Cited by 12 publications

References 48 publications

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

The Associations of Obstructive Sleep Apnea and Eye Disorders: Potential Insights into Pathogenesis and Treatment

Differential effects of obstructive sleep apnea on the corneal subbasal nerve plexus and retinal nerve fiber layer

Contact Info

Product

Resources

About