Periostin upregulates the effector functions of eosinophils

Noguchi, Tōru; Nakagome, Kazuyuki; Kobayashi, Takehito; Uchida, Yoshitaka; Soma, Tomoyuki; Nakamoto, Hidetomo; Nagata, Michio

doi:10.1016/j.jaci.2016.05.020

Cited by 49 publications

(42 citation statements)

References 16 publications

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“…Even after adjustment using albumin concentrations, the periostin/albumin ratio was higher in AEP and CEP patients than sarcoidosis patients, suggesting that periostin may be induced locally in EP, at least in part. In another study, we found that periostin upregulates eosinophil functions, such as adhesion, superoxide anion generation, and degranulation [30]. Therefore, periostin may also be involved in the activation of eosinophils in EP.…”

Section: Discussionmentioning

confidence: 99%

“…4c), the important source of which are likely to be eosinophils [37, 39-42]. We reported that periostin upregulates eosinophil functions including TGF-β production [30]. Periostin derived from epithelial cells upregulates the production and activation of TGF-β in epithelial cells through a matrix metalloproteinase-dependent mechanism [43].…”

Section: Discussionmentioning

confidence: 99%

“…Periostin also functions as a matricellular protein that binds to cell receptors and functions in activation cells, including eosinophils [27-30]. We recently reported that periostin induces eosinophil adhesion, superoxide anion generation, and degranulation through αMβ2 integrin [30].…”

Section: Introductionmentioning

confidence: 99%

“…We recently reported that periostin induces eosinophil adhesion, superoxide anion generation, and degranulation through αMβ2 integrin [30]. Because periostin is upregulated by T2 cytokines and activates eosinophils, it may play a role in the pathogenesis of EP.…”

Section: Introductionmentioning

confidence: 99%

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Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia

Nakagome

Nakamura

Kobayashi

et al. 2019

Int Arch Allergy Immunol

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Background: Eosinophilic pneumonia (EP) is characterized by massive pulmonary infiltration by eosinophils. Although serum periostin is a novel marker for eosinophil-dominant asthma, the upregulation of periostin in the airway of asthmatics is controversial. In this study, we examined whether periostin concentrations are elevated in the bronchoalveolar lavage fluid (BALF) of patients with EP. Methods: BAL was performed in healthy volunteers and in patients with acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia (CEP), and sarcoidosis. The periostin concentrations in the BALF were measured. Results: The periostin concentration in the BALF increased significantly with pulmonary eosinophil ia and was higher in AEP and CEP patients than in healthy volunteers and sarcoidosis patients, even after adjusting the albumin concentration. In pulmonary eosinophilia, the periostin concentration correlated with the eosinophil and lymphocyte counts, the concentration of albumin, and the concentration of cytokines such as IL-5, IL-13, and transforming growth factor β1. Conclusions: Although some blood leakage may be involved in the elevation of periostin in the BALF of EP, periostin can be induced locally, at least in part. Therefore, periostin may play a role in the development of EP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia

Nakagome

Nakamura

Kobayashi

et al. 2019

Int Arch Allergy Immunol

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“…Periostin promotes eosinophil adhesion and recruitment to the airways, which could contribute to increased airway type-2 inflammation and fibrosis in the lungs of participants with asthma [40,41]. It also activates eosinophil-specific functions: O 2 -generation and eosinophil-derived neurotoxin release [42]. Similarly to DPP-4, periostin is a noninvasive biomarker that can be measured in the blood using a validated immunoassay [43].…”

Section: Periostinmentioning

confidence: 99%

Tralokinumab for the Treatment of Severe, Uncontrolled Asthma: The ATMOSPHERE Clinical Development Program

et al. 2018

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Tralokinumab, a fully human IgG4 monoclonal antibody, specifically neutralizes IL-13. The ATMOSPHERE clinical development program comprised four randomized, placebo-controlled clinical trials and an open-label study that aimed to assess the efficacy and safety of tralokinumab for the treatment of severe, uncontrolled asthma. The two pivotal trials (STRATOS 1 and STRATOS 2; NCT02161757 and NCT02194699) evaluated the efficacy and safety of tralokinumab, with STRATOS 1 identifying a subgroup most likely to demonstrate enhanced response to treatment. Further trials have assessed the ability of tralokinumab to reduce oral corticosteroid use (TROPOS; NCT02281357) and determined its mechanistic effects (MESOS; NCT02449473). An open-label study in Japanese individuals (NCT02902809) assessed the long-term safety and tolerability of tralokinumab in this population.

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Increased Thrombin‐Activatable Fibrinolysis Inhibitor in Response to Sublingual Immunotherapy for Allergic Rhinitis

et al. 2021

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Objectives/Hypothesis: The objective of this study was to determine the role of thrombin-activatable fibrinolysis inhibitor (TAFI) as a candidate biomarker for therapeutic efficacy of sublingual immunotherapy (SLIT) and to identify the role of TAFI in the pathogenesis of allergic rhinitis (AR).Study Design: Retrospective cohort study and laboratory study. Methods: Serum was collected from patients with allergies to Japanese cedar pollen before, during, and after treatment with SLIT. We measured the levels of immunoreactive TAFI, C3a, and C5a in serum by enzyme-linked immunosorbent assay (ELISA) and assessed their relative impact on a combined symptom-medication score. We also examined the impact of TAFI on mast cells and fibroblasts in experiments performed in vitro.Results: Serum levels of TAFI increased significantly in response to SLIT. By contrast, serum C3a levels decreased significantly over time; we observed a significant negative correlation between serum levels of TAFI versus C3a and symptommedication score. Mast cell degranulation was inhibited in response to TAFI, as it was the expression of both CCL11 and CCL5 in cultured fibroblasts.Conclusions: High serum levels of TAFI may be induced by SLIT. TAFI may play a critical protective role in pathogenesis of AR by inactivating C3a and by inhibiting mast cell degranulation and chemokines expression in fibroblasts.

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Periostin upregulates the effector functions of eosinophils

Cited by 49 publications

References 16 publications

Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia

Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia

Tralokinumab for the Treatment of Severe, Uncontrolled Asthma: The ATMOSPHERE Clinical Development Program

Increased Thrombin‐Activatable Fibrinolysis Inhibitor in Response to Sublingual Immunotherapy for Allergic Rhinitis

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