Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury

Yokota, Kazuya; Kobayakawa, Kazu; Saito, Takeyuki; Hara, Michiya; Kijima, Ken; Ohkawa, Yasuyuki; Harada, Akihito; Okazaki, Ken; Ishihara, Kazuhíko; Yoshida, Shigeo; Kudo, Akira; Iwamoto, Yukihide; Okada, Seiji

doi:10.1016/j.ajpath.2016.11.010

Cited by 67 publications

(70 citation statements)

References 67 publications

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“…3D collagen I gels were also used to assess astrocyte reactivity to the presence of other cell types, including mesenchymal stem cells and Schwann cells (East et al, ). Notably, the reduced astrocyte reactivity in the presence of collagen I in these studies appears to be different from that reported with the 2D astrocyte culture study described above (Yokota et al, ). In another approach, astrocytes that were cultured on 3D electrospun poly‐ε‐caprolactone (PCL) scaffolds exhibit different morphological characteristics compared to 2D culture, further augmented by the addition of ROCK inhibitor (O'Shea et al, ).…”

Section: Introductioncontrasting

confidence: 94%

“…Caution should be taken when oversimplifying the role of a single protein, however, as it may have context‐dependent effects. For example, periostin has been detected in pericytes after SCI, and its reduced expression was correlated with an increase of functional outcome, possibly through reducing monocyte/macrophage activation (Yokota et al, ). As another complexity, activation of pSTAT3 may also result in differential astrocyte reactivity depending on the upstream stimulus.…”

Section: Introductionmentioning

confidence: 99%

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Concepts toward directing human astroplasticity to promote neuroregeneration

Patel

Muir

Cvetkovic

et al. 2018

Developmental Dynamics

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Astrocytes exhibit dynamic and complex reactions to various insults. Recently, investigations into the transitions that occur during cellular specification, differentiation, maturation, and disease responses have provided insights into understanding the mechanisms that underlie these altered states of reactivity and function. Here we summarize current concepts in how astrocyte state transitions, termed astroplasticity, are regulated, as well as how this affects neural circuit function through extracellular signaling. We postulate that a promising future approach toward enhancing functional repair after injury and disease would be to steer astrocytes away from an inhibitory response and toward one that is beneficial to neuroplasticity and neuroregeneration. Toward this goal, we discuss emerging biotechnological advancements, with a focus on human pluripotent stem cell bioengineering, which has high potential for effective manipulation and control of astroplasticity. Highlights include innovations in cellular transdifferentiation techniques, nanomedicine, organoid and three-dimensional (3D) spheroid microcircuit development, and the use of biomaterials to influence the extracellular environment. Current barriers and future applications are also summarized in order to augment the design of future preclinical trials aimed toward astrocyte-targeted neuroregeneration with a concept termed astrocellular therapeutics.

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Section: Introductioncontrasting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Concepts toward directing human astroplasticity to promote neuroregeneration

Patel

Muir

Cvetkovic

et al. 2018

Developmental Dynamics

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“…Induced by TGF‐b, IL‐4, and IL‐13, the POSTN gene can modulate the expression of several hub genes such as TGF‐band chemokines and regulate cellular behavior including cell proliferation, epithelial‐mesenchymal transition, and cell migration through interaction with several integrin receptors . High expression of POSTN was mainly observed in early embryonic tissues, adult periosteum, and periodontal ligament . The abnormal expression of POSTN in stromal cells was associated with an invasive and proliferative phenotype.…”

Section: Discussionmentioning

confidence: 99%

“…37,39 High expression of POSTN was mainly observed in early embryonic tissues, adult periosteum, and periodontal ligament. 40,41 The abnormal expression of POSTN in stromal cells was associated with an invasive and proliferative phenotype. Several studies have demonstrated that POSTN was critical in development of cardiovascular system, bone, and wound healing, and plays a key role in fibrotic changes of liver, lung, and skin.…”

Section: Discussionmentioning

confidence: 99%

Transcripto‐based network analysis reveals a model of gene activation in tongue squamous cell carcinomas

Zeng

Zhao

et al. 2019

Head & Neck

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Background Tongue squamous cell carcinoma (TSCC) is the most common malignant tumor derived from the oral cavity, yet its specific molecular mechanisms have not been fully clarified. The aim of this study was to evaluate the association between potential genes and clinical features through constructing gene co‐expression networks. Methods The weighted gene co‐expression network analysis was used to construct gene co‐expression networks and to identify candidate key modules and hub genes. The gene expression profiles of GSE31056 obtained from the Gene Expression Omnibus (GEO) database was used to construct co‐expression networks. Results Five hub genes (FAP, AGTRAP, PLOD1, POSTN, and TSHZ3) were identified and validated at transcriptional levels. Moreover, the protein levels of these five hub genes were also found significantly higher in tumor tissues. Among them, FAP was most associated with immune infiltration. Conclusions These five candidate biomarkers and therapeutic targets are worthy of further investigation and discussion.

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“…The extracellular matrix (ECM) is a prominent feature of the PNS and has been implicated in numerous developmental processes, including Schwann cell migration, radial sorting of axons, and myelination (18,19). In light of recent reports that found a role for ECM proteins in inflammation (20)(21)(22)(23)(24), we investigated their possible role in the development of SAPP (7). We found increased expression of the ECM protein periostin (POSTN) by Schwann cells in affected nerves of SAPP mice and patients with CIDP.…”

Section: Introductionmentioning

confidence: 99%

Schwann cell–derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment

Allard¹,

Wang²,

Li³

et al. 2018

Journal of Clinical Investigation

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Chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain-Barre syndrome (GBS) are inflammatory neuropathies that affect humans and are characterized by peripheral nerve myelin destruction and macrophage-containing immune infiltrates. In contrast to the traditional view that the peripheral nerve is simply the target of autoimmunity, we report here that peripheral nerve Schwann cells exacerbate the autoimmune process through extracellular matrix (ECM) protein induction. In a spontaneous autoimmune peripheral polyneuropathy (SAPP) mouse model of inflammatory neuropathy and CIDP nerve biopsies, the ECM protein periostin (POSTN) was upregulated in affected sciatic nerves and was primarily expressed by Schwann cells. Postn deficiency delayed the onset and reduced the extent of neuropathy, as well as decreased the number of macrophages infiltrating the sciatic nerve. In an in vitro assay, POSTN promoted macrophage chemotaxis in an integrin-AM (ITGAM) and ITGAV-dependent manner. The PNS-infiltrating macrophages in SAPP-affected nerves were pathogenic, since depletion of macrophages protected against the development of neuropathy. Our findings show that Schwann cells promote macrophage infiltration by upregulating Postn and suggest that POSTN is a novel target for the treatment of macrophage-associated inflammatory neuropathies.

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Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury

Cited by 67 publications

References 67 publications

Concepts toward directing human astroplasticity to promote neuroregeneration

Concepts toward directing human astroplasticity to promote neuroregeneration

Transcripto‐based network analysis reveals a model of gene activation in tongue squamous cell carcinomas

Schwann cell–derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment

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