Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis

Wang, Zhe; Xiong, Sidong; Mao, Yonghui; Chen, Mimi; Ma, Xiaohong; Zhou, Xueliang; Ma, Zhenling; Fan, Lida; Huang, Zhengjie; Luo, Qi; Ouyang, Gaoliang

doi:10.1002/path.4747

Cited by 81 publications

(88 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have demonstrated that POSTN was critical in development of cardiovascular system, bone, and wound healing, and plays a key role in fibrotic changes of liver, lung, and skin. It found that POSTN gene was also highly upregulated in various malignancies such as breast cancer, ovarian cancer, lung cancer, and glioma . Besides, POSTN was reported as progression‐associated factor and poor prognostic biomarker in glioma through regulating the maintenance of cancer stem cell during disease progression .…”

Section: Discussionmentioning

confidence: 99%

Transcripto‐based network analysis reveals a model of gene activation in tongue squamous cell carcinomas

Zeng

Zhao

et al. 2019

Head & Neck

View full text Add to dashboard Cite

Background Tongue squamous cell carcinoma (TSCC) is the most common malignant tumor derived from the oral cavity, yet its specific molecular mechanisms have not been fully clarified. The aim of this study was to evaluate the association between potential genes and clinical features through constructing gene co‐expression networks. Methods The weighted gene co‐expression network analysis was used to construct gene co‐expression networks and to identify candidate key modules and hub genes. The gene expression profiles of GSE31056 obtained from the Gene Expression Omnibus (GEO) database was used to construct co‐expression networks. Results Five hub genes (FAP, AGTRAP, PLOD1, POSTN, and TSHZ3) were identified and validated at transcriptional levels. Moreover, the protein levels of these five hub genes were also found significantly higher in tumor tissues. Among them, FAP was most associated with immune infiltration. Conclusions These five candidate biomarkers and therapeutic targets are worthy of further investigation and discussion.

show abstract

Section: Discussionmentioning

confidence: 99%

Transcripto‐based network analysis reveals a model of gene activation in tongue squamous cell carcinomas

Zeng

Zhao

et al. 2019

Head & Neck

View full text Add to dashboard Cite

show abstract

“…Consistently, members of the Serpin B clade are overexpressed in IF1-cells being some of its members directly related with suppression of migration and invasion in breast cancer (47), whereas its downregulation is associated with the aggressiveness of squamous cell carcinomas (48, 49). On the other hand, (i) ACTA2 which has been related to increased cell motility in breast cancer and other cancer types (50, 51), (ii) POSTN , a protein secreted by cancer cells that has been described to facilitate cell motility and was recently purposed as an interesting target for prevention and treatment of breast tumor metastasis (52, 53), and (iii) VCAN , known to enhance tumorigenesis and cell mobility, invasion, and survival of breast tumors (54), are all dramatically silenced in IF1-overexpressing breast cancer cells. Besides, we found that IF1 overexpression increased the presence of the epithelial marker E-cadherin involved in maintenance of cell and epithelial tissue integrity and inversely correlated with invasion and metastasis (55, 56).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer

et al. 2017

View full text Add to dashboard Cite

Partial suppression of mitochondrial oxidative phosphorylation and the concurrent activation of aerobic glycolysis is a hallmark of proliferating cancer cells. Overexpression of the ATPase inhibitory factor 1 (IF1), an in vivo inhibitor of the mitochondrial ATP synthase, is observed in most prevalent human carcinomas favoring metabolic rewiring to an enhanced glycolysis and cancer progression. Consistently, a high expression of IF1 in hepatocarcinomas and in carcinomas of the lung, bladder, and stomach and in gliomas is a biomarker of bad patient prognosis. In contrast to these findings, we have previously reported that a high expression level of IF1 in breast carcinomas is indicative of less chance to develop metastatic disease. This finding is especially relevant in the bad prognosis group of patients bearing triple-negative breast carcinomas. To investigate the molecular mechanisms that underlie the differential behavior of IF1 in breast cancer progression, we have developed the triple-negative BT549 breast cancer cell line that overexpresses IF1 stably. When compared to controls, IF1-cells partially shut down respiration and enhance aerobic glycolysis. Transcriptomic analysis suggested that migration and invasion were specifically inhibited in IF1-overexpressing breast cancer cells. Analysis of gene expression by qPCR and western blotting indicate that IF1 overexpression supports the maintenance of components of the extracellular matrix (ECM) and E-cadherin concurrently with the downregulation of components and signaling pathways involved in epithelial to mesenchymal transition. The overexpression of IF1 in breast cancer cells has no effect in the rates of cellular proliferation and in the cell death response to staurosporine and hydrogen peroxide. However, the overexpression of IF1 significantly diminishes the ability of the cells to grow in soft agar and to migrate and invade when compared to control cells. Overall, the results indicate that IF1 overexpression despite favoring a metabolic phenotype prone to cancer progression in the specific case of breast cancer cells also promotes the maintenance of the ECM impeding metastatic disease. These findings hence provide a mechanistic explanation to the better prognosis of breast cancer patients bearing tumors with high expression level of IF1.

show abstract

“…21 An increasing number of studies have shown that periostin over-expression presents in various malignant tumors and closely relates with disease progression. In vitro and in vivo researches demonstrated that periostin participate in key processes in cancer metastasis such as cancer stem cell maintenance, 22 tumor cell survival, 5 protumoral macrophages recruitment, 23 pre-metastatic niche formation, 24 epithelial mesenchymal transition (EMT), 25 and angiogenesis. 26 Increased periostin levels have been detected in serum of patients with some malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Predictive and prognostic value of serum periostin in advanced non–small cell lung cancer patients receiving chemotherapy

et al. 2017

View full text Add to dashboard Cite

Periostin is an extracellular matrix protein involved in tumorigenesis and metastasis. However, the role of serum periostin as a surrogate marker for treatment efficacy is still unknown. In 122 advanced non-small cell lung cancer cases, 37 patients with benign lung disease and 40 healthy controls, serum periostin was measured by enzyme-linked immunosorbent assays. The associations of serum periostin levels with the clinic-pathological parameters, chemotherapy response, and clinical outcomes of non-small cell lung cancer patients were analyzed. Serum periostin levels were significantly higher in non-small cell lung cancer patients, and it was related significantly to bone metastasis (p = 0.021). Serum periostin of 65 non-small cell lung cancer patients were detected before and after two cycles of chemotherapy. The patients with and without periostin response had significant difference in objective response to chemotherapy (p = 0.001). For the 122 non-small cell lung cancer patients, the median progression-free survival was 5 months. In a multivariate analysis, performance status (hazard ratio, 1.71; 95% confidence interval, 1.10-2.67), baseline periostin (hazard ratio, 1.01; 95% confidence interval, 1.00-1.01), and periostin response (hazard ratio, 0.50; 95% confidence interval, 0.29-0.86) were significantly correlated with prognosis. In conclusion, serum periostin was elevated in advanced non-small cell lung cancer patients. Baseline periostin and periostin responses appeared to be reliable surrogate markers to predict chemotherapy response and survival in patients with advanced non-small cell lung cancer.

show abstract

Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis

Cited by 81 publications

References 47 publications

Transcripto‐based network analysis reveals a model of gene activation in tongue squamous cell carcinomas

Transcripto‐based network analysis reveals a model of gene activation in tongue squamous cell carcinomas

Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer

Predictive and prognostic value of serum periostin in advanced non–small cell lung cancer patients receiving chemotherapy

Contact Info

Product

Resources

About