Periostin: its role in asthma and its potential as a diagnostic or therapeutic target

Li, Wei; Gao, Peng; Zhi, Yue; Xu, Wei; Wu, Yanfeng; Yin, Jinzhi; Zhang, Jie

doi:10.1186/s12931-015-0218-2

Cited by 100 publications

(79 citation statements)

References 70 publications

(136 reference statements)

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“…These data are supported by previous work showing that deficiency or inhibition of periostin prevents the development or progression of many allergic inflammatory diseases including allergic dermatitis, asthma and chronic rhinosinusitis. 44, 45 The presence of periostin in an inflammatory or injured environment appears to impart competency for macrophages to infiltrate and further impact disease.…”

Section: Discussionmentioning

confidence: 99%

Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling

Schwanekamp

Lorts

Vagnozzi

et al. 2016

ATVB

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Objective Periostin is a secreted protein that can alter extracellular matrix remodeling in response to tissue injury. However, the functional role of periostin in the development of atherosclerotic plaques has yet to be described despite its observed induction in diseased vessels and presence in the serum. Approach and Results Hyperlipidemic, apolipoprotein E-null mice (ApoE−/−) were crossed with periostin (Postn−/−) gene-deleted mice and placed on a high fat diet for 6 or 14 weeks to induce atherosclerosis. En face analysis of aortas showed significantly decreased lesion areas of ApoE−/− Postn−/− mice compared to ApoE−/− mice, as well as a reduced inflammatory response with less macrophage content. Moreover, diseased aortas from ApoE−/− Postn−/− mice displayed a disorganized extracellular matrix with less collagen cross linking and smaller fibrotic caps, as well as increased matrix metalloprotease-2, matrix metalloprotease-13, and procollagen-lysine, 2-oxoglutarate 5-dioxygenase-1 mRNA expression. Furthermore, loss of periostin was associated with a switch in vascular smooth muscle cells towards a more proliferative and synthetic phenotype. Mechanistically, loss of periostin reduced macrophage recruitment by transforming growth factor-β in cellular migration assays. Conclusions These are the first genetic data detailing the function of periostin as a regulator of atherosclerotic lesion formation and progression. The data suggest that periostin could be a therapeutic target for atherosclerotic plaque formation through modulation of the immune response and extracellular matrix remodeling.

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Section: Discussionmentioning

confidence: 99%

Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling

Schwanekamp

Lorts

Vagnozzi

et al. 2016

ATVB

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“…Isoforms of periostin also exist due to alternative splicing and have been linked to cancers (249). In addition, periostin has been associated with numerous pathological conditions including asthma, skin disorders, polycystic kidney disease, and cardiovascular disease (247, 250–254). …”

Section: Introductionmentioning

confidence: 99%

Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization

Sawyer

Kyriakides

2016

Advanced Drug Delivery Reviews

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Extracellular matrix is composed by a complex array of molecules that together provide structural and functional support to cells. These properties are mainly mediated by the activity of collagenous and elastic fibers, proteoglycans, and proteins such as fibronectin and laminin. ECM composition is tissue-specific and could include matricellular proteins whose primary role is to modulate cell-matrix interactions. In adults, matricellular proteins are primarily expressed during injury, inflammation and disease. Particularly, they are closely associated with the progression and prognosis of cardiovascular and fibrotic diseases, and cancer. This review aims to provide an overview of the potential use of matricellular proteins in drug delivery including the generation of therapeutic agents based on the properties and structures of these proteins as well as their utility as biomarkers for specific diseases.

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“…Nowadays, it is well recognized that the thickening of the epithelial-connective tissue interface in asthma is the consequence of excessive deposits of collagen types I, III, and V, associated to fibronectin and tenascin-C. Periostin identification in the same location as these extracellular matrix protein supports the assertion that they represent different components of the bronchial subepithelial fibrosis [9,16]. These initial observations have been later completed by other studies which revealed an increased periostin serum or sputum level in patients with allergic bronchial asthma [12,17,18]. Thus, an increased periostin level associated with eosinophilia and Th2 mediated inflammation is seen in a specific type of bronchial asthma.…”

Section: Periostin and Bronchial Asthmamentioning

confidence: 84%

“…It appears that periostin enhanced expression is responsible for the induction of eosinophils recruitment in bronchial wall [12] and its ability to act as α v β 3 , α v β 5 , α 4 β 6 , and α M β 2 (CD11b) integrin ligand increases eosinophils adherence to fibronectin [25][26][27].…”

Section: Periostin and Bronchial Asthmamentioning

confidence: 99%

See 1 more Smart Citation

Periostin in bronchial asthma – a brief update

Grigoraș¹,

Lozneanu²,

Grigoraş³

et al. 2017

Arch Clin Cases

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Periostin is an extracellular matrix protein which intervenes in the regulation of angiogenesis, and in tumoral cells proliferation and invasion. Recent studies, mainly experimental models, have demonstrated the intervention of this molecule in asthmatic disease, by eosinophils recruitment, bronchial wall remodeling, and by stimulation of inflammatory cytokines production. Currently, periostin is considered a marker of type 2 inflammation in asthma, being secreted by respiratory epithelial cells triggered by IL-13 and IL-4. Concomitantly, periostin accumulated at the bronchial epithelial-connective tissue interface is involved in fibrogenesis and mucus secretion, in correlation with the intensity of bronchial mucosa eosinophilic inflammatory infiltrate. However, the intimate molecular mechanisms of periostin involvement in the pathogenic pathway of asthmatic diseases is far away from elucidation, further research being necessary to certify its value as a biomarker useful in diagnosis and in establishment of therapeutic schemes in bronchial asthma.

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Periostin: its role in asthma and its potential as a diagnostic or therapeutic target

Cited by 100 publications

References 70 publications

Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling

Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling

Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization

Periostin in bronchial asthma – a brief update

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